scholarly journals Secondary Syphilis Presenting as Glossodynia, Plaques en Prairie Fauchée, and a Split Papule at the Oral Commissure: Case Report and Review

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Walter de Araujo Eyer-Silva ◽  
Maria Alessandra Leite Freire ◽  
Cecília Angelina Horta-Araujo ◽  
Guilherme Almeida Rosa da Silva ◽  
Jorge Francisco da Cunha Pinto ◽  
...  
Keyword(s):  
Secondary Syphilis ◽  
Oral Lesions ◽  
Review Of The Literature ◽  
Cutaneous Lesions ◽  
Infected Male ◽  
Full Spectrum ◽  
Posterior Aspect ◽  
Complete Clinical Remission ◽  
Penicillin Therapy ◽  
Oral Commissure

Syphilis has been coined “the great imitator” due to its extreme heterogeneity of presentation and mimicry of other conditions. Therefore, it is essential that physicians be familiar with the full spectrum of its manifestations. Syphilis may also lead to oral lesions that, occasionally, are unaccompanied by concomitant tegumentary findings. Such patients will pose unique diagnostic challenges. We report the case of a 45-year-old HIV-infected male patient in whom secondary syphilis presented with burning mouth and dysgeusia that progressed to glossodynia and odynophagia. Examination revealed painful, shallow erosions on the posterior aspect of the tongue, in a pattern of plaques en prairie fauchée. A painful split papule (fausse perlèche or false angular cheilitis) was also present in the left commissure. There were no cutaneous lesions. The oral lesions were considered highly suggestive of secondary syphilis. A novel VDRL assay (which was previously negative) yielded a titer of 1/128. Complete clinical remission was rapidly achieved after initiation of penicillin therapy. A comprehensive review of the literature on oral manifestations of syphilis is offered.

scholarly journals Mucous patch on the tongue as isolated manifestation of the secondary stage of syphilis: Case report

2012 ◽  
Vol 59 (3) ◽  
pp. 160-163
Author(s):  
Milan Bjekic ◽  
Sandra Sipetic
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Secondary Syphilis ◽  
Oral Lesions ◽  
Oral Diseases ◽  
Cutaneous Lesions ◽  
Syphilis Infection ◽  
Transmitted Infection ◽  
Systemic Antibiotic Therapy ◽  
Secondary Stage

Introduction. Syphilis is sexually transmitted infection caused by the anaerobic spirochete Treponema pallidum. Oral lesions are present and described in all stages of the disease. These lesions as well as blood and saliva of infected persons are highly contagious in early syphilis. The aim of this case report was to point out to the possibility of the secondary syphilis in differential diagnosis of oral diseases. Case Report. A 38-year-old asymptomatic man showed up at the clinic with suspicious of syphilis infection. Clinical presentation of the disease was a mucous patch on the tongue, however no other mucous membrane or cutaneous lesions were detected. No lymph nodes were enlarged. The serologic tests on syphilis were positive. After conducting systemic antibiotic therapy with benzathine penicillin the tongue lesion disappeared. Conclusion. Depending on the clinical picture, the possibility of syphilis should not be overlooked in the differential diagnosis of oral lesions.

LINEAR NEVUS SEBACEOUS SYNDROME: REPORT OF TWO CASES AND A REVIEW OF THE LITERATURE

PEDIATRICS ◽  
1973 ◽  
Vol 52 (3) ◽  
pp. 382-387
Author(s):  
Frederick H. Lovejoy ◽  
William E. Boyle
Keyword(s):  
Cerebrospinal Fluid ◽  
Neurologic Disease ◽  
Review Of The Literature ◽  
Cutaneous Lesions ◽  
Neurocutaneous Syndromes ◽  
Nevus Sebaceous ◽  
Cerebrospinal Fluid Protein ◽  
Syndrome Report

Two cases of linear nevus sebaceous syndrome are described and a review of the eleven cases now reported in the literature is undertaken. The first patient has retardation, seizures, and classic ectodermal lesions while the second patient manifests typical cutaneous lesions and only an elevated cerebrospinal fluid protein as evidence of neurologic disease. The rationale for defining the syndrome as an entity distinct from other neurocutaneous syndromes is discussed and a pleomorphic presentation of the syndrome is suggested.

scholarly journals Hypomelanosis of Ito: Case report of a rare neurocutaneous syndrome in a neonate and review of the literature.

1970 ◽  
Vol 42 (3) ◽  
pp. 231-233
Author(s):  
M Mukhtar-yola ◽  
LI Audu ◽  
AT Otuneye ◽  
AB Mairami ◽  
EC Otubelu ◽  
...  
Keyword(s):  
Case Report ◽  
High Index ◽  
Review Of The Literature ◽  
Cutaneous Lesions ◽  
Hypomelanosis Of Ito ◽  
The Third ◽  
Neurocutaneous Syndrome ◽  
Paediatric Practice ◽  
High Index Of Suspicion

Hypomelanosis of Ito (HI) though said to be the third most common neurocutaneus disorder, is rarely reported in paediatric practice in Africa. A high index of suspicion must be maintained in children with cutaneous lesions as a seizure may be the first symptom that may bring the child to attention. A case of HI in a neonate is hereby reported to sensitize clinicians about this relatively uncommon disorder

Sarcoidosis Can Present with Necrotizing Granulomas Histologically: Two Cases of Ulcerated Sarcoidosis and Review of the Literature

2013 ◽  
Vol 17 (6) ◽  
pp. 377-383 ◽  
Author(s):  
Kristin Noiles ◽  
Katie Beleznay ◽  
Richard I. Crawford ◽  
Sheila Au
Keyword(s):  
Differential Diagnosis ◽  
Inflammatory Disorder ◽  
Review Of The Literature ◽  
Cutaneous Sarcoidosis ◽  
Cutaneous Lesions ◽  
Delay In Diagnosis ◽  
Cutaneous Involvement ◽  
Histopathologic Findings ◽  
Histopathologic Features ◽  
Necrotizing Granulomas

Background: Sarcoidosis is a systemic inflammatory disorder with cutaneous involvement present in 25% of cases. The presence of naked granulomas histologically is the hallmark of sarcoidosis. The presence of necrotizing granulomas is highly suggestive of other granulomatous conditions and leads the clinician to pursue other diagnoses, such as infectious causes. Objectives: We describe two cases of sarcoidosis in which necrotizing granulomas were present on biopsy. Both patients had ulcerated cutaneous lesions of sarcoidosis. In one case, the presence of these atypical histologic features led to a delay in diagnosis of almost 10 years. We review the various histopathologic findings associated with cutaneous sarcoidosis and discuss a potential connection between ulcerated sarcoidosis and atypical histologic findings. Conclusion: When atypical histopathologic features are present, the differential diagnosis of sarcoidosis should not be excluded.

Calciphylaxis in a Patient With Non-Hodgkin Lymphoma: Case Report and Literature Review

2018 ◽  
Vol 22 (5) ◽  
pp. 524-526 ◽  
Author(s):  
Meggie Morand ◽  
Myrna Chababi-Atallah ◽  
Sara-Élizabeth Jean ◽  
Carolina Fernandes
Keyword(s):  
Systematic Review ◽  
Hodgkin Lymphoma ◽  
Rare Condition ◽  
Skin Lesions ◽  
Review Of The Literature ◽  
End Stage Kidney Disease ◽  
Cutaneous Lesions ◽  
Non Hodgkin Lymphoma ◽  
End Stage ◽  
High Index Of Suspicion

Background: Calciphylaxis is a well-known entity in end-stage kidney disease and after renal transplant. Cases of nonuremic calciphylaxis (NUC) have also been reported, but data on this rare condition are mainly empirical. Objective: We discuss a case of NUC secondary to spontaneous tumour lysis syndrome in a patient who had chemotherapy for non-Hodgkin lymphoma and present a review of the literature to better characterize malignancy-associated NUC. Methods: We identified 12 published cases of malignancy-associated NUC. Results: This systematic review of malignancy-associated NUC did not show a relationship between the type of malignancy, the distribution of skin lesions, or mortality. However, distal more than proximal involvement seems to be more frequently associated with calcium phosphate imbalance. Conclusion: Clinicians must maintain a high index of suspicion for calciphylaxis when evaluating patients with cutaneous lesions developed in the setting of malignancy.

Oral Lesions as a Diagnostic Indicator of Secondary Syphilis

2015 ◽  
Vol 120 (2) ◽  
pp. e54
Author(s):  
HELENE DOS SANTOS CARVALHO PEREIRA ◽  
NATHÁLIA DE ALMEIDA FREIRE ◽  
WAGNER CHAGAS ◽  
MARIA ELIZA BARBOSA RAMOS ◽  
SARAH APARECIDA ANTERO ◽  
...  
Keyword(s):  
Secondary Syphilis ◽  
Oral Lesions ◽  
Diagnostic Indicator

A chemiluminescent light system in combination with toluidine blue to assess suspicious oral lesions—clinical evaluation and review of the literature

2014 ◽  
Vol 19 (2) ◽  
pp. 459-466 ◽  
Author(s):  
P. W. Kämmerer ◽  
R. K. Rahimi-Nedjat ◽  
T. Ziebart ◽  
A. Bemsch ◽  
C. Walter ◽  
...  
Keyword(s):  
Clinical Evaluation ◽  
Toluidine Blue ◽  
Oral Lesions ◽  
Review Of The Literature ◽  
Light System

First Presentation of Hereditary Leiomyomatosis and Renal Cell Cancer Syndrome in Pregnancy

2016 ◽  
Vol 20 (4) ◽  
pp. 334-336
Author(s):  
Kathryn Woolner ◽  
Ashley O’Toole ◽  
Lauren LaBerge
Keyword(s):  
Renal Cell Cancer ◽  
Renal Cell ◽  
Cell Cancer ◽  
Fumarate Hydratase ◽  
Case Series ◽  
Review Of The Literature ◽  
Cancer Syndrome ◽  
Cutaneous Lesions ◽  
Hereditary Leiomyomatosis ◽  
In Pregnancy

Background: Reed’s syndrome, also known as hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome, is an autosomal dominant condition in which affected individuals may develop cutaneous leiomyomas, uterine fibroids, and renal cell carcinoma. Objective: This report describes a unique case of HLRCC because it presented in pregnancy with development of cutaneous pilar leiomyomas. Methods: Review of the literature for previous cases of Reed’s syndrome during pregnancy including PubMed and Medline search. Results: Genetic testing of this patient demonstrated a mutation in the fumarate hydratase ( FH) gene. Review of the literature showed only 1 previous case series that described the onset of cutaneous lesions during pregnancy. Conclusion: This case serves as a reminder that there may exist a correlation between pregnancy and the first manifestation of cutaneous lesions in patients with HLRCC, and thus an increased clinical suspicion is warranted during this period.

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