scholarly journals Clinical and microbiological effects of the initial periodontal therapy

2014 ◽  
Vol 142 (1-2) ◽  
pp. 10-16 ◽  
Author(s):  
Tanja Predin ◽  
Milanko Djuric ◽  
Jelena Mirnic ◽  
Ivana Gusic ◽  
Nadja Nikolic ◽  
...  
Keyword(s):  
Porphyromonas Gingivalis ◽  
Chronic Periodontitis ◽  
Statistical Significance ◽  
Aggregatibacter Actinomycetemcomitans ◽  
Initial Therapy ◽  
Primary Objective ◽  
Periodontal Therapy ◽  
Prevotella Intermedia ◽  
Pocket Depth ◽  
Tannerella Forsythensis

Introduction. Periodontitis is a destructive inflammatory disease of the tooth-supporting tissues, primarily caused by Gram-negative microorganisms. Thus, the primary objective of cause-related initial periodontal therapy is disruption and removal of the subgingival biofilm. Objective. The aim of this study was to evaluate the clinical and microbiological effects of the initial therapy in patients diagnosed with chronic periodontitis. Methods. Forty patients with chronic periodontitis were included in the study. As a part of the clinical assessment undertaken prior to the initial therapy, as well as one month and three months post-therapy, plaque index, gingival index, papilla bleeding index, probing pocket depth and clinical attachment level were recorded. Microbiological testing was performed prior to the initial therapy and three months after therapy. Polymerase chain reaction assays were used to determine the presence of Porphyromonas gingivalis, Tannerella forsythensis, Prevotella intermedia and Aggregatibacter actinomycetemcomitans. Results. All clinical parameters were significantly reduced after therapy. The prevalence of Aggregatibacter actinomycetemcomitans was reduced by 22.5%, which was a statistically significant decrease compared to the baseline. The prevalence of Porphyromonas gingivalis, Tannerella forsythensis and Prevotella intermedia tended to decrease after therapy; however, the difference did not reach statistical significance. Conclusion. The results of the present study demonstrated the beneficial effects of the initial periodontal therapy on both the clinical and microbiological parameters.

scholarly journals Association between clinical parameters and the presence of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis in patients with progressive periodontal lesions

2010 ◽  
Vol 67 (11) ◽  
pp. 898-902 ◽  
Author(s):  
Mia Rakic ◽  
Ksenija Zelic ◽  
Dusan Pavlica ◽  
Milos Hadzimihajlovic ◽  
Jelena Milasin ◽  
...  
Keyword(s):  
Porphyromonas Gingivalis ◽  
Statistical Tests ◽  
Statistical Significance ◽  
Aggregatibacter Actinomycetemcomitans ◽  
Chronic Inflammatory Disease ◽  
Clinical Parameters ◽  
Pocket Depth ◽  
Periodontal Tissues ◽  
Index Index ◽  
Destructive Processes

Background/Aim. Periodontitis is a chronic inflammatory disease of periodontal tissues with consequential is bone loss as a result of host immunological reactions caused by periopathogens. The aim of the study was to investigate if there is a correlation between clinical parameters and the presence of two most aggressive periopathogens (Aggregatibacter actinomycetemcomitans - Aa and Porphyromonas gingivalis - Pg) in patients with progressive periodontal lesions. Methods. A total of 34 systemic healthy people, 23 to 70 years old, were included in the study. The patients were clinically and radiologically examined, and after that, the representative pocket with greatest pocket depth was chosen and the sample was collected from that place. The measured clinic parameters were: gingival index, index of gingival bleeding, pocket depth and plaque indices. The multiplex Polymerase Chain Reaction (PCR) method was used for detection of periopathogens. After obtaining results, appropriate statistical tests were used to correlate the clinical and microbiological results. Results. Aa and Pg were detected in the same percentage of samples. Aa and Pg were detected in 35.29% samples alone, and in 29.41% both were detected. The values of measured clinical parameters did not show a statistical significance between the groups. In analysis of correlations among clinical parameters inside the groups, a statistical significance was found only between gingival and plaque index in the group with Aa. Conclusion. Clinical course of periodontitis in the developed stage does not differ in relation to the presence of different periopathogens as the major inductors of immunologically guided destructive processes.

scholarly journals Effects of Lactobacillus Reuteri Lozenges (Prodentis) as Adjunctive Therapeutic Agent in Non-Surgical Therapy of Periodontitis

2021 ◽  
Vol 25 (1) ◽  
pp. 41-45
Author(s):  
Zerina Hadžić ◽  
Enes Pašić ◽  
Mirjana Gojkov Vukelić ◽  
Sanja Hadžić
Keyword(s):  
Porphyromonas Gingivalis ◽  
Therapeutic Agent ◽  
Lactobacillus Reuteri ◽  
Aggregatibacter Actinomycetemcomitans ◽  
Periodontal Therapy ◽  
Periodontal Treatment ◽  
Prevotella Intermedia ◽  
Scaling And Root Planing ◽  
Root Planing ◽  
Nonsurgical Periodontal Therapy

SummaryBackground/Aim: This study aimed to evaluate the effects of Lactobacillus reuteri lozenges as an adjunctive therapeutic agent in combination with scaling and root planing in a randomized, clinical trial of volunteers with periodontitis stage IV.Material and Methods: The study included 40 patients diagnosed with periodontitis divided into 2 groups of 20 patients by random sample method. The first group of patients used Lactobacillus reuteri lozenges after nonsurgical periodontal therapy for a period of 40 days while the second group of patients was treated with non-surgical periodontal therapy without lozenges. Periodontal clinical parameters were registered for all patients before treatment and after 40 days. Samples of saliva from patients before and 40 days after treatment were analyzed by the PCR method for pathogens Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Prevotella intermedia. Assessments were made on day 0 before treatment for patients of both groups and after 40 days.Results: Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis show a statistically significant difference between the two study groups. Results were not statistically significant for Prevotella intermedia (P= 0.5598).Conclusions: The present study confirms the positive effects of L. reuteri lozenges after non-surgical periodontal therapy and the maintenance phase of periodontal treatment. Considering the beneficial effects of probiotics, L.reuteri could serve as a useful adjunct or maybe even as an alternative to periodontal treatment when scaling and root planing might be contraindicated or has to be postponed.

Optimization of the terms of supportive periodontal therapy using photoactivated disinfection

2019 ◽  
Vol 24 (2) ◽  
pp. 121-126 ◽  
Author(s):  
V. G. Atrushkevich ◽  
L. Yu. Orekhova ◽  
O. O. Yanushevich ◽  
E. Yu. Sokolova ◽  
E. S. Loboda
Keyword(s):  
Chronic Periodontitis ◽  
Adjunctive Treatment ◽  
Control Group ◽  
Clinical Parameters ◽  
Ozone Therapy ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Supportive Periodontal Therapy ◽  
Tannerella Forsythensis ◽  
Observation Period

Relevance: to indentify if periodontal treatment which is presented by photoactivated disinfection (PAD) adjunctively to scaling and root planing (SRP) yield better outcomes than ozone therapy as an adjunct to SRP in periodontitis.Materials and methods: we examined 57 (mean age 49,3 ± 1,02) patients with chronic periodontitis, divided into groups, SRP + PAD, SRP + ozone therapy and SRP alone. Subgingival plaque samples were subjected to DNA extraction and real time PCR amplifcation for detection Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi), Tannerella forsythensis (Tf), Treponema denticola (Td), Aggregatibacter actinomycetemcomitans (Aa). The amount of periodontopathogens and clinical parameters including plaque index, clinical attachment loss, pocket depth, bleeding on probing were measured at baseline, after 40, 90 and 180 days.Results: the results in groups of PAD+SRP and ozone therapy+SRP showed an improvement in all clinical parameters PI, BOP, PD, CAL and the quantity of Pg, Td and Tf compared to the control group during an observation period.Conclusion: the results showed additional benefts from PAD and ozone therapy as an adjunctive treatment to SRP for patients of chronic periodontitis.

Профилактика воспалительных заболеваний ротовой полости у человека с помощью комбинации пробиотических штаммов Streptococcus salivarius BLIS K12 и BLIS M18 в наземном изоляционном эксперименте «SIRIUS-19»

2021 ◽  
Author(s):  
Л. Прокопович
Keyword(s):  
Porphyromonas Gingivalis ◽  
Aggregatibacter Actinomycetemcomitans ◽  
Treponema Denticola ◽  
Prevotella Intermedia ◽  
Streptococcus Salivarius

Изучены синергия штаммов саливарного стрептококка BLIS K12 и M18 в ходе профилактики воспаления ротоглотки, а также возможности инвазии протективной микрофлоры в процессе межличностного общения в замкнутом пространстве искусственной среды обитания. Впервые в клинической практике изучено влияние пробиотиков на основе саливарного стрептококка на пародонтопатогены I и II порядков: Prevotella intermedia, Tanerella forsythia, Treponema denticola, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis. Полученные результаты можно расценивать как положительные. По результатам наземного эксперимента «SIRIUS-19» планируется проводить закупки для космических экспериментов с шифрами «Пародонт» и «Пародонт-ЛОР».

scholarly journals Effect of Nonsurgical Periodontal Therapy on Crevicular Fluid and Serum Glutathione Peroxidase Levels

2012 ◽  
Vol 32 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Swati Pradeep Patel ◽  
Nishanth S. Rao ◽  
A. R. Pradeep
Keyword(s):  
Oxidative Stress ◽  
Glutathione Peroxidase ◽  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Periodontal Diseases ◽  
Periodontal Therapy ◽  
Enzyme Linked Immunosorbent Assay ◽  
Pocket Depth ◽  
Nonsurgical Periodontal Therapy ◽  
Crevicular Fluid

Background: Plasma glutathione peroxidase (eGPx) is an important selenium containing antioxidant in human defense against oxidative stress. While crevicular fluid (GCF) eGPx levels and its association with periodontal disease is well documented, there is no data on correlation of GCF and serum eGPx levels in chronic periodontitis. Hence this study was undertaken to further probe into the role of oxidative stress in periodontal diseases and effect of nonsurgical periodontal therapy (NSPT) by correlating GCF and serum levels of eGPx.Materials and methods: Thirty subjects (16-Males and 14-Females; age: 30–38 years) participated in the study. The subjects were divided, based on gingival index, probing pocket depth and clinical attachment level into: Healthy (group-1,n=10), Gingivitis (group-2,n=10) and Periodontitis (group-3,n=10). Chronic periodontitis patients after NSPT constituted group 4. GCF and serum samples collected from each subject were quantified for eGPx levels using Enzyme linked Immunosorbent Assay.Results: The mean eGPx concentrations increased from health (14.01 ng/μl and 78.26 ng/ml) to gingivitis (22.86 ng/μl and 90.44 ng/ml) and then to periodontitis (29.89 ng/μl and 103.43 ng/ml), in GCF and serum respectively. After NSPT, there was statistically significant reduction in eGPx concentration in GCF and serum (19.41 ng/μl and 85.21 ng/ml). Further, all the GCF eGPx values showed a positive correlation to that of serum eGPx level.Conclusion: Thus, increased eGPx concentration in GCF can be considered as an indicator of local increase in oxidative stress. While, increase in serum eGPx levels indicates that periodontal disease can also lead to increased oxidative stress at the systemic level.

scholarly journals Effect of Switching to the Tobacco Heating System Versus Continued Cigarette Smoking on Chronic Generalized Periodontitis Treatment Outcome: Protocol for a Randomized Controlled Multicenter Study (Preprint)

2019 ◽  
Author(s):  
Sandrine Pouly ◽  
Wee Teck Ng ◽  
Muriel Benzimra ◽  
Alexandre Soulan ◽  
Nicolas Blanc ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Periodontal Disease ◽  
Harm Reduction ◽  
Significant Risk ◽  
Product Category ◽  
Heating System ◽  
Primary Objective ◽  
Periodontal Therapy ◽  
Pocket Depth ◽  
Randomized Controlled

BACKGROUND Smoking is a significant risk factor for periodontal disease and tooth loss, as shown in several clinical studies comparing smokers and nonsmokers. Although only a few longitudinal studies have assessed the outcome of periodontal disease after smoking cessation, they indicated that recovery after nonsurgical treatment was more successful in those who had quit smoking. As part of tobacco harm reduction strategies, substituting cigarettes with alternative, less harmful tobacco products is an approach complementary to cessation for smokers who would otherwise continue to smoke. The Tobacco Heating System (THS), developed by Philip Morris International (commercialized as IQOS), is part of the heat-not-burn product category. The IQOS device electrically heats tobacco instead of burning it, at much lower temperatures than cigarettes, thereby producing substantially lower levels of harmful and potentially harmful constituents, while providing the nicotine, taste, ritual, and a sensory experience that closely parallel those of cigarettes. Phillip Morris International has published the results from a broad clinical assessment program, which was established to scientifically substantiate the harm reduction potential of the THS among adult healthy smokers switching to the THS. The program is now progressing toward including adult smokers with smoking-related diseases. OBJECTIVE The goal of this study is to demonstrate favorable changes of periodontal endpoints in response to mechanical periodontal therapy in patients with generalized chronic periodontitis who completely switched to THS use compared with continued cigarette smoking. METHODS This is a randomized controlled two-arm parallel-group multicenter Japanese study conducted in patients with chronic generalized periodontitis who switch from cigarettes to THS compared with smokers continuing to smoke cigarettes for 6 months. The patients were treated with mechanical periodontal therapy as per standard of care in Japan. The primary objective of the study is to demonstrate the beneficial effect of switching to THS use compared with continued cigarette smoking on pocket depth (PD) reduction in all sites with an initial PD≥4 mm. The secondary objectives include evaluation of other periodontal parameters (eg, clinical attachment level or gingival inflammation) and overall oral health status upon switching to THS. Safety was monitored throughout the study. RESULTS In total, 172 subjects were randomized to the cigarette (n=86) or THS (n=86) groups, and all 172 completed the study. The conduct phase of the study is completed, while data cleaning and analyses are ongoing. CONCLUSIONS This study is the first to test a heat-not-burn tobacco product in smokers with an already established disease. The results should further strengthen the evidence that switching to THS can significantly reduce the risk of smoking-related diseases if favorable changes in the evolution of chronic generalized periodontitis after mechanical therapy are found when compared with continued cigarette smoking. CLINICALTRIAL ClinicalTrials.gov NCT03364751; https://clinicaltrials.gov/ct2/show/NCT03364751 INTERNATIONAL REGISTERED REPORT DERR1-10.2196/15350

scholarly journals Effects of initial periodontal therapy on the prevalence of Epstein-Barr virus DNA and Porphyromonas gingivalis in Japanese chronic periodontitis patients

2019 ◽  
Author(s):  
Ayako Kato ◽  
Yorinobu Ikeda ◽  
Kenichi Imai ◽  
Yorimasa Ogata
Keyword(s):  
Porphyromonas Gingivalis ◽  
Chronic Periodontitis ◽  
Epstein Barr Virus ◽  
Periodontal Therapy ◽  
Subgingival Plaque ◽  
Clinical Parameters ◽  
Periodontal Pathogens ◽  
Barr Virus ◽  
Ebv Dna ◽  
Epstein Barr

Abstract Background Initial periodontal therapy (IPT) is cornerstone of periodontal therapy and the first step to control of periodontal risk factors. Scaling and root planing are used to treat root surface irregularities and remove virulent factors caused by periodontal pathogens. This procedure also incorporated into periodontal surgery. To elucidate the effects of IPT on prevalence of Epstein-Barr virus (EBV) DNA and Porphyromonas gingivalis, we used subgingival plaque samples from chronic periodontitis (CP) patients. Methods Seventeen CP patients were recruited and measured periodontal clinical parameters such as probing pocket depth (PD) and bleeding on probing (BOP), and subgingival plaque samples were collected from two periodontal sites with PD of <3 mm (healthy sites: HS) or >5 mm (periodontitis sites: PS) at first visit and after IPT. Plaque samples were subjected to a real-time PCR to detect EBV DNA and P. gingivalis. Results EBV DNA and P. gingivalis were detected 9 (52.9%) and 14 (82.3%) in the subgingival samples from HS, and 13 (76.5%) and 14 (82.3%) in the PS at first visit. After IPT, number of detections of EBV DNA and P. gingivalis were decreased to 5 (29.4%) and 13 (76.5%) in the HS, and 9 (52.9%) and 10 (58.8%) in the PS. Significant improvements in PD and BOP were observed after IPT in PS. Coexistence of EBV DNA and P. gingivalis in the subgingival samples from PS at first visit (12; 70.6%) were significantly decreased after IPT (6; 35.3%). Conclusion These results suggest that the IPT was effective in improvement of clinical parameters such as PD and BOP and reducing the coexistence of EBV and P. gingivalis in the subgingival plaque from PS. However, IPT could not eradicate the EBV and P. gingivalis. Further research would be necessary for improving the periodontal treatment strategy.

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