scholarly journals Hyperbaric oxygen therapy of angiopathic changes in patients with inherited gene imbalance

2007 ◽  
Vol 135 (11-12) ◽  
pp. 669-671 ◽  
Author(s):  
Predrag Brkic ◽  
Ana Mitrovic ◽  
Miodrag Rakic ◽  
Mirko Grajic ◽  
Tomislav Jovanovic
Keyword(s):  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Monozygotic Twins ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Doppler Imaging ◽  
Vascular Surgeon ◽  
Chromosomal Pair

Introduction Phenotype match inherited by genes is in most cases present in monozygotic twins. Their phenotypic resemblance is unfortunately characterized by strong susceptibility for the development of chronic non-infectious diseases. One of the most common non-infectious chronic diseases that are phenotipically represented in twins is diabetes mellitus. Genetic imbalance is, in most cases, placed in 2, 3, 7, 8, 11, 12, 19 and 20 chromosomal pair of the human genome. CASE OUTLINE This study describes a pair of monozygotic twins, aged 54, who were diagnosed for diabetes type 2 ten years earlier. The first patient had trophic changes of muscles and skin tissues of the lower limb, and a necrotic wound on his right leg tibial region with the claudication distance of 50 m. After arteriography, he was referred by a vascular surgeon for hyperbaric oxygen therapy (HBO). HBO protocol implied 70 min. application of 100% oxygen at 2.5 absolute atmospheres. After the first series of HBO therapies consisting of 20 HBO treatments, claudication was eliminated and the necrotic wound healed. Next, surgical aortofemoral bypass was done. During the second HBO treatment, his monozygotic twin brother presented with angiopathic changes due to diabetes. In both patients, biochemical parameters corresponded to the expected level for diabetes type 2 imbalance, and the localization of the chromosomal defect (placed on 3, 11 and 19 chromosomal pair) was also in accordance with the respective disorder. After they were included into next 10 HBO treatments, Doppler imaging of the major arteries of limbs revealed normal findings. Conclusion Identical genetic impairment in monozygotic twins can lead to identical somatic changes with resultant consequences. HBO treatment of such patients associated with other therapeutic procedures (conducted by diabetologist, vascular surgeon and physiatrist) can postpone or prevent irreversible changes occurring due to blood vessel disorders.

scholarly journals Hyperbaric Oxygen Therapy in Ischaemic Foot Ulcers in Type 2 Diabetes: A Clinical Trial

2018 ◽  
Vol 12 (1) ◽  
pp. 80-85 ◽  
Author(s):  
Sarah Perren ◽  
Alfred Gatt ◽  
Nikolaos Papanas ◽  
Cynthia Formosa
Keyword(s):  
Type 2 Diabetes ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Foot Ulcer ◽  
Treatment Modalities ◽  
Foot Ulcers ◽  
Ulcer Area ◽  
Group A

Background and Aims: Several treatment modalities and protocols for ischaemic foot ulcers are available. However, little consensus exists on optimal treatment. The aim of this study was to compare Standard Wound Care (SWC) alone vs. SWC with adjunct hyperbaric oxygen therapy (HBOT) in the treatment of ischaemic Diabetic Foot Ulcers (DFUs). Patients and Methods: Twenty-six patients with Type 2 Diabetes Mellitus (T2DM) presenting with a newly diagnosed ischaemic foot ulcer were included. These were divided into group A (SWC with adjunct HBOT) and group B (SWC only). Participants were followed every week for 4 weeks and their ulcers were measured for their surface area and depth to assess any change in wound size. Results: Both treatment arms succeeded in reducing ulcer area and depth (p<0.001). However, ulcer area (p<0.001) and depth (p<0.001) exhibited superior improvement in group A. Conclusion : Adjunctive HBOT appears to improve wound healing in ischaemic DFUs and merits further study.

scholarly journals Treatment of a Chronic Vulvar Wound by Hyperbaric Oxygen Therapy (HBOT)

2022 ◽  
Vol 2022 ◽  
pp. 1-3
Author(s):  
D. Ricard-Gauthier ◽  
M.-A. Panchard ◽  
D. E. Huber
Keyword(s):  
Type 2 Diabetes ◽  
Obese Patient ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Wound Care ◽  
Surgical Drainage ◽  
Skin Atrophy ◽  
Labia Majora

We hereby report the case of a 66-year-old obese patient (BMI 30) with type 2 diabetes, who presented a chronic vulvar lesion on the left labia majora following surgical drainage of an abscess. After multiple unsuccessful treatments by antibiotics and local wound care, we proposed a trial of hyperbaric oxygen therapy (HBOT). The patient fully recovered after 54 sessions at 2.5 ATA, 95 minutes each. HBOT has been studied for perineal lesion such as skin atrophy or necrosis caused by irradiation but not for vulvar nonhealing chronic lesions in the case of impaired vascularization caused by diabetes. This case is, to our knowledge, one of the first publications about the healing boost of HBOT in chronic vulvar wounds due to vascular impairment.

scholarly journals EFEKTIVITAS TERAPI OKSIGEN HIPERBARIK TERHADAP KADAR GULA DARAH PASIEN DIABETES MELLITUS

2017 ◽  
Vol 3 (1) ◽  
pp. 19
Author(s):  
Inggried Angelica Valentina Wiliyams Peni
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Blood Sugar Level ◽  
Oxygen Therapy ◽  
Cross Sectional ◽  
Post Test ◽  
Sugar Levels

ABSTRAK Indonesia termasuk dalam 7 negara dengan prevalensi diabetes tertinggi di dunia menurut data dari International Diabetes Federasi (IDF) tahun 2013. Tujuan dari penelitian ini adalah untuk mengetahui apakah ada perubahan kadar gula pasien DM tipe 2 sebelum dan setelah terapi oksigen hiperbarik. Metode penelitian ini adalah metode kuantitatif yang bersifat cross sectional dengan desain pre expereimental one group pre-test and post- test design. Populasi penelitian ini adalah pasien DM tipe 2 di Rumah Sakit Advent Bandung, sebanyak 8 orang yang berjenis kelamin perempuan dan yang berusia ≥40 tahun menjadi sampel yang telah dipilih secara purposive sampling. Hasil penelitian, rata-rata kadar gula darah pasien sebelum terapi adalah 257,25 mg/dL dan rata-rata kadar gula darah pasien sesudah terapi adalah 176,00 mg/dL. Hasil uji statistik untuk keefektivan terapi oksigen terhadap kadar gula darah telah diukur menggunakan paired T-test memiliki nilai probabilitas 0,000 < 0,05. Kesimpulan penelitian ini adalah terapi oksigen hiperbarik mempunyai pengaruh terhadap menurunkan kadar gula darah sewaktu yang signifikan. Untuk menggembangkan penelitian ini diharapkan kepada peneliti selanjutnya untuk memperhatikan pada jumlah kalori yang dikonsumsi dan interval lama pasien terdiagnosa DM atau melakukan penelitian ulang.   Kata Kunci : Terapi Oksigen Hiperbarik, Diabetes Mellitus, Kadar Gula Darah   ABSTRACT Indonesia is among the 7 countries with the highest prevalence of diabetes in the world according to data from the International Diabetes Federation (IDF) in 2013. The purpose of this study was to determine whether there is a change in blood sugar levels of patient with type 2 diabetes before and after hyperbaric oxygen therapy. This research method is quantitative method which is cross sectional with pre experimental design one group pre-test and post-test. The population of this study is the patient with type 2 diabetes mellitus in Adventist Bandung Hospital, 8 people of woman and over the age of 40 years into a sample that has been selected by purposive sampling. The result of this study, the mean of patient’s blood sugar level before therapy was 257,25 mg/dl and the mean of patient’s blood sugar level after therapy was 176,00 mg/dl. Statistical test result for the effectiveness of oxygen therapy to blood sugar levels were measured using paired t-test having a probability value 0,000 < 0,05. The conclusion of this study is hyperbaric oxygen therapy has an effect on decreasing blood sugar level. To develop this study is expected for next researchers to pay attention to the number of calories consumed and the intervals of patient diagnosed diabetes mellitus or re-do this study. Keywords: Hyperbaric Oxygen Therapy, Blood Sugar Levels, Diabetes Mellitus

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