scholarly journals Slowing down of chronic renal failure progression with captopril in spontaneously hypertensive rats with adriamycin nephropathy

2002 ◽  
Vol 130 (3-4) ◽  
pp. 73-80 ◽  
Author(s):  
Dijana Jovanovic ◽  
Djurdjica Jovovic ◽  
Jasmina Varagic ◽  
Jovan Dimitrijevic ◽  
Zorica Dragojlovic ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Early Stage ◽  
Systemic Blood Pressure ◽  
Hypertensive Rats ◽  
Systemic Blood ◽  
Spontaneously Hypertensive ◽  
Functional Changes ◽  
Slowing Down ◽  
Adriamycin Nephropathy

In SHRs with ADR nephropathy treatment with captopril normalized systemic blood pressure, and slowed down CRF progression in their early stage. These functional changes correlate with significant slowing of glomerular and interstitial changes.

scholarly journals Electroacupuncture Delays Hypertension Development through Enhancing NO/NOS Activity in Spontaneously Hypertensive Rats

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Hye Suk Hwang ◽  
Yoo Sung Kim ◽  
Yeon Hee Ryu ◽  
Ji Eun Lee ◽  
Young Seop Lee ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Mesenteric Artery ◽  
Spontaneously Hypertensive Rats ◽  
Early Stage ◽  
Acupuncture Point ◽  
Hypertensive Rats ◽  
Treatment Control ◽  
Blood Pressure Elevation ◽  
Spontaneously Hypertensive

Using spontaneously hypertensive rats (SHR), this study investigated whether electroacupuncture (EA) could reduce early stage hypertension by examining nitric oxide (NO) levels in plasma and nitric oxide synthase (NOS) levels in the mesenteric resistance artery. EA was applied to the acupuncture point Governor Vessel 20 (GV20) or to a non-acupuncture point in the tail twice weekly for 3 weeks under anesthesia. In conscious SHR and normotensive Wistar Kyoto (WKY) rats, blood pressure was determined the day after EA treatment by the tail-cuff method. We measured plasma NO concentration, and evaluated endothelial NO syntheses (eNOS) and neuronal NOS (nNOS) protein expression in the mesenteric artery. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were lower after 3 weeks of GV20 treatment than EA at non-acupuncture point and no treatment control in SHR. nNOS expression by EA was significantly different between both WKY and no treatment SHR control, and EA at GV20 in SHR. eNOS expression was significantly high in EA at GV 20 compared with no treatment control. In conclusion, EA could attenuate the blood pressure elevation of SHR, along with enhancing NO/NOS activity in the mesenteric artery in SHR.

Effect of Chronic Clonidine Treatment and its Abrupt Cessation on Mean Blood Pressure of Rats with a Normal or An Elevated Blood Pressure

1979 ◽  
Vol 57 (2) ◽  
pp. 195-201 ◽  
Author(s):  
J. Atkinson ◽  
Nicole Boillat ◽  
Roselyne Pera-Bally ◽  
Lise Peters-Haefeli ◽  
E. J. Kirchertz
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Early Stage ◽  
Mean Blood Pressure ◽  
Average Dose ◽  
Elevated Blood ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Induced Hypertension ◽  
Drinking Fluid

1. Clonidine (6 mg of base/1 of water) was given as drinking fluid to normotensive rats or rats with established or early hypertension. 2. Spontaneous hypertensive rats (6 months old: average dose of clonidine, 0·6 mg 24 h−1 kg−1) showed a sustained fall in blood pressure over 3 weeks. 3. The same clonidine solution given for 6 weeks to two-kidney Goldblatt rats with early-stage hypertension (average dose of clonidine: 1 mg 24 h−1 kg−1) or spontaneously hypertensive rats (clonidine dose: 1 mg) induced a fall in mean blood pressure, but no change in normotensive rats. 4. Replacement of clonidine by water induced hypertension and lability which led to death in hypertensive but not in normotensive rats.

scholarly journals Transcriptomic signature of gut microbiome-contacting cells in colon of spontaneously hypertensive rats

2020 ◽  
Vol 52 (3) ◽  
pp. 121-132 ◽  
Author(s):  
Tao Yang ◽  
Hongbao Li ◽  
Aline C. Oliveira ◽  
Ruby Goel ◽  
Elaine M. Richards ◽  
...  
Keyword(s):  
Blood Pressure ◽  
T Cell ◽  
Spontaneously Hypertensive Rats ◽  
Colonic Epithelium ◽  
Hypertensive Rats ◽  
Fecal Matter ◽  
Cell Surface Glycoprotein ◽  
Spontaneously Hypertensive ◽  
Functional Changes ◽  
Lower Expression

Fecal matter transfer from hypertensive patients and animals into normotensive animals increases blood pressure, strengthening the evidence for gut-microbiota interactions in the control of blood pressure. However, cellular and molecular events involved in gut dysbiosis-associated hypertension remain poorly understood. Therefore, our objective in this study was to use gene expression profiling to characterize the gut epithelium layer in the colon in hypertension. We observed significant suppression of components of T cell receptor (TCR) signaling in the colonic epithelium of spontaneously hypertensive rats (SHR) when compared with Wistar Kyoto (WKY) normotensive rats. Western blot analysis confirmed lower expression of key proteins including T cell surface glycoprotein CD3 gamma chain (Cd3g) and lymphocyte cytosolic protein 2 (Lcp2). Furthermore, lower expression of cytokines and receptors responsible for lymphocyte proliferation, differentiation, and activation (e.g., Il12r, Il15ra, Il7, Il16, Tgfb1) was observed in the colonic epithelium of the SHR. Finally, Alpi and its product, intestinal alkaline phosphatase, primarily localized in the epithelial cells, were profoundly lower in the SHR. These observations demonstrate that the colonic epithelium undergoes functional changes linked to altered immune, barrier function, and dysbiosis in hypertension.

scholarly journals Effect of Chinese Medicine Xinmaitong on Blood Pressure in Spontaneously Hypertensive Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Bin Zhang ◽  
Dong Li ◽  
Gexiu Liu ◽  
Wenfeng Tan ◽  
Jun Guo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Treatment Group ◽  
Protein Expression ◽  
Spontaneously Hypertensive Rats ◽  
Early Stage ◽  
Control Group ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Protein Levels ◽  
Mrna And Protein Expression

Objective. To investigate the effect of traditional Chinese antihypertensive compound Xinmaitong on blood pressure and vasoactive factors of vasoconstrictor endothelin-1 (ET-1) and vasodilator calcitonin gene related peptide (CGRP) in spontaneously hypertensive rats (SHRs) with early stage hypertension. Methods. Twenty male SHRs were randomly divided into two groups: 10 for hypertensive control group and 10 for hypertensive treatment group. In addition, 10 Wistar rats were used as the normal control group without any intervention. SHRs of hypertensive treatment group were orally treated with Xinmaitong, while the hypertensive control group was treated with the normal saline (NS) for a total of eight weeks. The blood pressure in SHRs was examined before and after the end of the eight-week study. After treatment, the rats were killed and the blood samples were collected to measure plasma levels of ET-1 and CGRP by ELISA method, respectively. Meanwhile, the aorta rings were isolated for measuring the mRNA expression of ET-1 and CGRP by PCR. Moreover, the protein levels of ET-1 and CGRP were studied by immunohistochemical. Results. Daily oral administration of Xinmaitong resulted in significant fall in the SHRs’ blood pressure, including systolic and diastolic blood pressures (SBP and DBP), mean blood pressure (MBP), and pulse pressure (PP). The plasma ET-1 levels were reduced and CGRP increased. In parallel, the mRNA and protein expression of ET-1 were decreased, whereas the mRNA and protein expression of CGRP were enhanced in SHRs treated with Xinmaitong. Conclusion. The present study demonstrated for the first time that Xinmaitong leads to the fall in blood pressure of SHRs and that this antihypertensive effect is, at least in part, due to improvement of arterial tone.

Sign in / Sign up

Export Citation Format

Share Document