scholarly journals Technetium-99m in production and use

2009 ◽  
Vol 24 (1) ◽  
pp. 68-73 ◽  
Author(s):  
Jurij Vucina ◽  
Nadezda Nikolic ◽  
Djokica Petrovic
Keyword(s):  
Nuclear Reactions ◽  
Technetium 99M ◽  
Sodium Pertechnetate ◽  
99Mtc Radiopharmaceuticals ◽  
99Mtc Generator ◽  
Uranium Fission

Several types of generators have been developed for the production of 99mTc. Due to its excellent performances, the chromatographic type, based on the fission-produced 99Mo sorbed in alumina, is predominant. Technetium-99m is obtained in the form of sodium pertechnetate-99mTc. However, due to the known disadvantages of the production of (n, f)99Mo, attempts are made to avoid uranium fission. The technologies based on (n, g)99Mo (sublimation, extraction, gel) are, with the exception of the gel generator, of limited importance. Certain nuclear reactions in cyclotrons can produce 99Mo (or directly 99mTc) but the obtained results are still not satisfying. Technetium-99m is used in the form of radiopharmaceuticals which are prepared by addition of 99mTc-eluate to the inactive components comprised in the 'cold' kits. The chromatographic (n, f)99Mo/99mTc generator and several 99mTc-radiopharmaceuticals have been developed and are regularly produced in the Vinca Institute of Nuclear Sciences (Laboratory for Radioisotopes).

99mTc Technetium Sulfide and the Scintillation Camera in the Rapid Diagnosis of Pericardial Effusion

1971 ◽  
Vol 10 (02) ◽  
pp. 122-128
Author(s):  
W. H. Blahd ◽  
M. A. Winston ◽  
G. T. Krishnamurthy ◽  
P. B. Thomas ◽  
E. Weiss
Keyword(s):  
Pericardial Effusion ◽  
Patient Positioning ◽  
Rapid Diagnosis ◽  
Scintillation Camera ◽  
Technical Error ◽  
Technetium 99M ◽  
Sodium Pertechnetate ◽  
Specific Uptake ◽  
Speed Accuracy

SummaryBecause of its speed, accuracy, and reproducibility, radioisotopic angiocardiography appears to be the method of choice for the diagnosis of pericardial effusion. Technetium-99m sulfide is preferable to 99mTc sodium pertechnetate in these studies for the following reasons: (1) its specific uptake by the liver aids both in patient positioning and in the accuracy of diagnosis; and (2), studies can be repeated within 15—20 minutes should there be equiment or technical error.

scholarly journals Experimental models using radionuclides for assessment of the effects of natural drugs

2008 ◽  
Vol 51 (spe) ◽  
pp. 169-174 ◽  
Author(s):  
Silvana Ramos Farias Moreno ◽  
Jorge José de Carvalho ◽  
Bernardo Rebello ◽  
Emely Kazan Rocha ◽  
Margareth de Oliveira Timóteo ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Ginkgo Biloba ◽  
Blood Cells ◽  
Experimental Models ◽  
Significant Alteration ◽  
Blood Constituents ◽  
Technetium 99M ◽  
Sodium Pertechnetate ◽  
Natural Drugs

The aim of this study was to evaluate the effect of the extracts of Nectandra membranacea (N. membranacea), Ginkgo biloba (EGb) and Passiflora (PEF) on the morphology of red blood cells (RBC), on the biodistribution of sodium pertechnetate (99mTcO4Na), on the morphology of duodenum and on the labeling of blood constituents (BC, IF-P, IF-BC) with technetium-99m (Tc-99m). Morphometry studies also were performed. The results show that EGb promotes alteration of the labeling of BC, IF-P and IF-BC (p<0.05). The N. membranacea extract does not promote significant alteration of the radiolabeling, and PEF extract alters the IF-P labeling. N. membranacea, EGb and PEF extracts were able to alter the RBC morphology (P<0.05). N. membranacea extract and EGb modifies the biodistribution of the 99mTcO4Na, and EGb influences the morphometry of duodenum isolated from rats (P<0.05).

scholarly journals Deteksi Karakteristik Peluruhan Radionuklida Medis 99Mo Untuk Memperoleh 99mTc Menggunakan Spektrometer Gamma dengan Sumber Standar Cair Campuran 133Ba dan 152Eu

2020 ◽  
Vol 24 (2) ◽  
pp. 96
Author(s):  
Mawar - Mawar ◽  
Sri Dewi Astuti ◽  
Siska Febriana
Keyword(s):  
Nuclear Medicine ◽  
Half Life ◽  
Liquid Mixture ◽  
Product Formation ◽  
Optimal Time ◽  
Bone Scanning ◽  
Radioisotope Production ◽  
Technetium 99M ◽  
The Third ◽  
99Mtc Generator

Technetium-99m (99mTc) is a subsidiary of metastable 99Mo with a half-life of 6 hours. The relatively short half-life, causing 99mTc widely used for diagnostic purposes in nuclear medicine, especially in bone scanning for a faster decay. This research aims to determine the optimal time to product formation of 99mTc until elution profiles have detected 99Mo energy. The instrument used is the 99Mo/99mTc generator with standard sources 133Ba and 152Eu liquid mixture. The results obtained showed that 99mTc radioisotope production is still good until the third day elution 99Mo, whereas in the fourth to ninth day 99Mo energy detected on the decline, so that the activity of the 99mTc resulting product cannot be used for diagnosis.

DISTRIBUTION OF NUCLEAR CHARGE IN THE PROTON-INDUCED FISSION OF Th232

1958 ◽  
Vol 36 (12) ◽  
pp. 1691-1706 ◽  
Author(s):  
B. D. Pate ◽  
J. S. Foster ◽  
L. Yaffe
Keyword(s):  
Fission Product ◽  
Charge Distribution ◽  
Cross Sections ◽  
Nuclear Reactions ◽  
Nuclear Charge ◽  
Yield Data ◽  
Induced Fission ◽  
The Cross ◽  
Bombarding Energy ◽  
Uranium Fission

The cross sections for the independent formation of I130, I131, Te131, I132, and I134 and for the cumulative formation of Te132, I133, and I135 in the proton-induced fission of Th232 have been measured at nine proton energies between 8 and 87 Mev. From these data and from published total chain yield data, charge distribution curves have been obtained. These are compared with published charge distribution curves for uranium fission at energies up to 480 Mev and together they show a shift of the most probable fission product charge toward stability and a widening of the distribution with increasing bombarding energy. These phenomena are interpreted in terms of current models for nuclear reactions.

scholarly journals Biodistribution of technetium-99m pertechnetate after Roux-en-Y gastric bypass (Capella technique) in rats

2010 ◽  
Vol 25 (1) ◽  
pp. 9-12 ◽  
Author(s):  
Amália Cínthia Meneses do Rêgo ◽  
Irami Araújo-Filho ◽  
Ítalo Medeiros Azevedo ◽  
Daniel Tôrres Jácome ◽  
Rachel de Alcântara Oliveira Ramalho ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Gastric Bypass ◽  
Nuclear Medicine ◽  
Statistical Analysis ◽  
T Test ◽  
Control Group ◽  
Technetium 99M ◽  
Sodium Pertechnetate ◽  
Significant Difference

PURPOSE: The biodistribution of sodium pertechnetate, the most used radiopharmaceutical in nuclear medicine, has not been studied in details after bariatric surgery. The objective was to investigate the effect of Roux-en-Y gastric bypass (RYGB) on biodistribution of sodium pertechnetate (Na99mTc-) in organs and tissues of rats. METHODS: Twelve rats were randomly divided into two groups of 6 animals each. The RYGB group rats were submitted to the Roux-en-Y gastric bypass and the control group rats were not operated. After 15 days, all rats were injected with 0.1mL of Na99mTc- via orbital plexus with average radioactivity of 0.66 MBq. After 30 minutes, liver, stomach, thyroid, heart, lung, kidney and femur samples were harvested, weighed and percentage of radioactivity per gram (%ATI/g) of each organ was determined by gama counter Wizard Perkin-Elmer. We applied the Student t test for statistical analysis, considering p<0.05 as significant. RESULTS: Significant reduction in mean %ATI/g was observed in the liver, stomach and femur in the RYGB group animals, compared with the control group rats (p<0.05). In other organs no significant difference in %ATI/g was observed between the two groups. CONCLUSION: This work contributes to the knowledge that the bariatric surgery RYGB modifies the pattern of biodistribution of Na99mTc-.

scholarly journals Effect of medicinal plants on the parasitemia of Trypanosoma cruzi and on the biodistribution of sodium pertechnetate (Na99mTcO4)

2008 ◽  
Vol 51 (spe) ◽  
pp. 209-214 ◽  
Author(s):  
Roseane Pereira da Silva ◽  
Cecília Maria de Carvalho Xavier Holanda ◽  
Vanessa Santos de Arruda Barbosa ◽  
Daniel Pereira de Oliveira ◽  
Natália Alves Lima ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Medicinal Plants ◽  
Trypanosoma Cruzi ◽  
Antimalarial Drug ◽  
Biological Effects ◽  
Aloe Vera ◽  
Artemisia Vulgaris ◽  
Technetium 99M ◽  
Sodium Pertechnetate ◽  
Plant Effects

Artemisia vulgaris (AV) is an antihelmintic and antimalarial drug; Aloe vera(babosa) acts as antidiabetic, laxative and anti-inflammatory;Benznidazole (BZ) is a trypanocidal of Trypanosoma cruzi (TC). Technetium-99m (99mTc) has been used in nuclear medicine to obtain diagnostic images. This study evaluated the plant effects in TC parasitemia and on the biodistribution of 99mTc in mice. Twenty mice were infected by TC. At the peak of parasitemia, 5 mice received babosa; 5 received AV and 5 received BZ. The parasitemia was determined at 0, 2, 4 and 6 h of drugs administration. Five infected mice without drugs, 5 mice without TC and the group treated with AV, received 99mTc. The radioactivity was calculated. Infected mice that received babosa reduced significantly (p<0.05) the TC parasitemia. The percentage of activity per gram (%ATI/g) decreased significantly on the AV group. These results indicate that babosa possibly is an anti-TC drug and AV reduces the %ATI/g probably due to its biological effects.

scholarly journals Technetium-99m radiopharmaceuticals for in vivo diagnostics

2005 ◽  
Vol 58 (3-4) ◽  
pp. 180-184 ◽  
Author(s):  
Divna Djokic
Keyword(s):  
Inorganic Compounds ◽  
Radiation Detector ◽  
Carrier Free ◽  
Carrier Molecule ◽  
In Vivo Diagnostics ◽  
Biological Distribution ◽  
99Mtc Radiopharmaceuticals ◽  
Tracer Molecules ◽  
99Mtc Generator

Technetiiim-99m is an ideal radionuclide with optimum decay characteristics. It can be obtained in sterile, pyrogen-free and carrier-free condition, as sodium pertechnetate (Na99mTcO4), from 99Mo/99Tc generator. Because of its six-hour physical half-life and monochromatic 140 keV photons free of -radiation, administration of small amounts of 99mTc solution is possible, without a significant radiation damage to the patient. Technetium eluted from the 99Mo/99mTc generator is in the highest oxidation form (+7). It can be used for diagnostic purposes alone, but it is often used for labeling different organic and inorganic compounds. As it is unreactive, reduction with a chemical reductant, (+1), (+3) and (+5) oxidation are necessary before use. Nowadays almost 80% of radiopharmaceuticals are based on 99mTc. Radiopharmaceuticals. Radiopharmaceuticals are radionuclides or radioactive compounds used in diagnosis and therapy of human diseases. A pharmaceutical is chosen based on its localization in the organ, or its participation in its physiological function. Radiation emitted from a radionuclide is detected by a radiation detector. The ability to incorporate available radionuclides into tracer molecules has been the main goal in developing radiopharmaceuticals. As radionuclides with nuclear characteristics used as either diagnostic or therapeutic radiopharmaceuticals, are predominantly metals, they can be designed as metal essential, whereby biological distribution is determined by coordination compound, or metal tagged, in which case the properties of the carrier molecule (ligand system) determine the biological distribution. This paper reviews the development of 99mTc-radiopharmaceuticals. .

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