scholarly journals Topical agents in burn care

2002 ◽  
Vol 55 (3-4) ◽  
pp. 109-113 ◽  
Author(s):  
Dragan Momcilovic
Keyword(s):  
Antimicrobial Agents ◽  
Silver Sulfadiazine ◽  
Fluid Replacement ◽  
Burn Wound ◽  
Burn Care ◽  
Drug Of Choice ◽  
Invasive Infections ◽  
Fluid Replacement Therapy ◽  
Low Toxicity ◽  
Topical Antimicrobial

Introduction Understanding of fluid shifts and recognition of the importance of early and appropriate fluid replacement therapy have significantly reduced mortality in the early post burn period. After the bum patient successfully passes the resuscitation period, the burn wound represents the greatest threat to survival. History Since the dawn of civilization, man has been trying to find an agent which would help burn wounds heal, and at the same time, not harm general condition of the injured. It was not until the XX century, after the discovery of antibiotics, when this condition was fulfilled. In 1968, combining silver and sulfadiazine, fox made silver-sulfadiazine, which is a 1% hydro-soluble cream and a superior agent in topical treatment of burns today. Current topical agents None of the topical antimicrobial agents available today, alone or combined, have the characteristics of ideal prophylactic agents, but they eliminate colonization of burn wound, and invasive infections are infrequent. With an excellent spectrum of activity, low toxicity, and ease of application with minimal pain, silver-sulfadiazine is still the most frequently used topical agent. Conclusion The incidence of invasive infections and overall mortality have been significantly reduced after introduction of topical burn wound antimicrobial agents into practice. In most burn patients the drug of choice for prophylaxis is silver sulfadiazine. Other agents may be useful in certain clinical situations.

Efficacy of Topical Antimicrobial Agents Against Bacterial Isolates From Burn Wounds

2020 ◽  
Vol 41 (4) ◽  
pp. 739-742
Author(s):  
William Nethery ◽  
Petra Warner ◽  
Paula Durkee ◽  
Angela Dwyer ◽  
Jacquelyn Zembrodt ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Polymyxin B ◽  
Silver Sulfadiazine ◽  
Bacterial Isolates ◽  
Prevention Of Infection ◽  
Burn Care ◽  
Topical Antimicrobials ◽  
Neomycin Sulfate ◽  
Topical Antimicrobial

Abstract Topically applied antimicrobials are key to the prevention of infection and mortality in the acute burn population. The purpose of this study was to determine the in vitro effectiveness of commercially available topical antimicrobials, as well as topical preparations that were compounded in our burn care institution. One-hundred twenty microorganisms were tested against these topical antimicrobials and in vitro effectiveness was observed. Results showed that compounded preparations of 1:1:1 + Double Antibiotic (1 part bacitracin: 1 part silver sulfadiazine: 100,000 units/g nystatin + 5 mg/g neomycin sulfate + 500 units/g polymyxin B) and 3:1 + Double Antibiotic (3 part bacitracin: 1 part silver sulfadiazine + 5mg/g neomycin sulfate + 500 units/g polymyxin B) were effective against 100% of the isolates tested. Other topical agents showed moderate effectiveness, thus demonstrating the need for multiple topical agents to reach a broad spectrum of microorganisms. However, the development of topical antimicrobial resistance needs further study.

In Vivo Comparison of Two Silver Sulfadiazine Antimicrobial Agents on Burn Wound Infection

1987 ◽  
Vol 8 (5) ◽  
pp. 381-383 ◽  
Author(s):  
Vic Velanovich ◽  
John P. Heggers ◽  
Martin C. Robson ◽  
Steven M. Zoellner ◽  
Thomas P. McHugh ◽  
...  
Keyword(s):  
Wound Infection ◽  
Antimicrobial Agents ◽  
Silver Sulfadiazine ◽  
Burn Wound

Comparison of Battlefield-Expedient Topical Antimicrobial Agents for the Prevention of Burn Wound Sepsis in a Rat Model

2005 ◽  
Vol 26 (4) ◽  
pp. 357-361 ◽  
Author(s):  
David S. Kauvar ◽  
Eric Acheson ◽  
Joanna Reeder ◽  
Kristin Roll ◽  
David G. Baer
Keyword(s):  
Rat Model ◽  
Antimicrobial Agents ◽  
Burn Wound ◽  
Wound Sepsis ◽  
Topical Antimicrobial

Burn Wound Management

1993 ◽  
Vol 4 (2) ◽  
pp. 378-387 ◽  
Author(s):  
Pamela H. Walter
Keyword(s):  
Antimicrobial Agents ◽  
Bacterial Colonization ◽  
Stable Condition ◽  
Wound Management ◽  
Practical Application ◽  
Burn Wound ◽  
Treatment Protocols ◽  
Initial Care ◽  
Topical Antimicrobial ◽  
Selection Of

Management of a burn wound is interrelated with many patient care protocols. After the patient has received initial care, is in stable condition, and has been transported to the appropriate medical facility, the selection of burn wound treatment protocols is based on patient population. Hydrotherapy, debridement, topical antimicrobial agents, and dressings reduce bacterial colonization until the wound closes. Supportive care is essential to the preservation of viable tissue. Excision and autografting are the primary method of wound management. The practical application of cultured autograft and growth factors is under study

scholarly journals A Narrative Review of the History of Skin Grafting in Burn Care

Medicina ◽  
2021 ◽  
Vol 57 (4) ◽  
pp. 380
Author(s):  
Deepak K. Ozhathil ◽  
Michael W. Tay ◽  
Steven E. Wolf ◽  
Ludwik K. Branski
Keyword(s):  
Donor Site ◽  
Subsequent Development ◽  
Skin Grafting ◽  
Human Condition ◽  
Surgical Instruments ◽  
Wound Management ◽  
Burn Wound ◽  
Medical Progress ◽  
Burn Care ◽  
History Of

Thermal injuries have been a phenomenon intertwined with the human condition since the dawn of our species. Autologous skin translocation, also known as skin grafting, has played an important role in burn wound management and has a rich history of its own. In fact, some of the oldest known medical texts describe ancient methods of skin translocation. In this article, we examine how skin grafting has evolved from its origins of necessity in the ancient world to the well-calibrated tool utilized in modern medicine. The popularity of skin grafting has ebbed and flowed multiple times throughout history, often suppressed for cultural, religious, pseudo-scientific, or anecdotal reasons. It was not until the 1800s, that skin grafting was widely accepted as a safe and effective treatment for wound management, and shortly thereafter for burn injuries. In the nineteenth and twentieth centuries skin grafting advanced considerably, accelerated by exponential medical progress and the occurrence of man-made disasters and global warfare. The introduction of surgical instruments specifically designed for skin grafting gave surgeons more control over the depth and consistency of harvested tissues, vastly improving outcomes. The invention of powered surgical instruments, such as the electric dermatome, reduced technical barriers for many surgeons, allowing the practice of skin grafting to be extended ubiquitously from a small group of technically gifted reconstructive surgeons to nearly all interested sub-specialists. The subsequent development of biologic and synthetic skin substitutes have been spurred onward by the clinical challenges unique to burn care: recurrent graft failure, microbial wound colonization, and limited donor site availability. These improvements have laid the framework for more advanced forms of tissue engineering including micrografts, cultured skin grafts, aerosolized skin cell application, and stem-cell impregnated dermal matrices. In this article, we will explore the convoluted journey that modern skin grafting has taken and potential future directions the procedure may yet go.

Topical Antimicrobial Agents in Wound Care

1998 ◽  
Vol 7 (Sup2) ◽  
pp. 13-16 ◽  
Author(s):  
R. Cooper ◽  
J.C. Lawrence
Keyword(s):  
Antimicrobial Agents ◽  
Wound Care ◽  
Topical Antimicrobial
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