scholarly journals Phytochemical study of the genus amphoricarpos

2021 ◽  
pp. 83-83
Author(s):  
Iris Djordjevic ◽  
Mirjana Cvetkovic ◽  
Milka Jadranin ◽  
Srdjan Bojovic ◽  
Boban Andjelkovic ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Herbal Medicine ◽  
Secondary Metabolites ◽  
Folk Medicine ◽  
Plant Diseases ◽  
Biologically Active ◽  
Early 20Th Century ◽  
Isolation And Identification ◽  
Plant Adaptation ◽  
Phytochemical Study

Phytochemistry deals with the study of secondary metabolites produced by plants that synthesize these compounds for many reasons, including their own protection against attack of herbivores and plant diseases. Secondary metabolites are believed to represent plant adaptation to various environmental factors and that they enabled the survival of the species. Secondary metabolites of plants can have curative or toxic effects in humans and animals. Herbal medicine has a long tradition in folk medicine and until the early 20th century, when synthetic organic chemistry began to develop, plants were the main source of medicines. Basic goals of our phytochemical research include the following: isolation and identification of new (biologically active) compounds - potential drugs, and chemotaxonomy (chemosystematics). In the following text through one selected example - genus Amphoricarpos Vis. - both aspects of our phytochemical research are shown.

scholarly journals COMPARATIVE PHYTOCHEMICAL STUDY OF THE AERIAL PARTS OF THE WILD-GROWING AND CULTIVAT-ED CHICORY ORDINARY (CICHORIUM INTYBUS L.)

2020 ◽  
pp. 187-195
Author(s):  
Ol'ga Leonidovna Saybel ◽  
Andrey Ivanovich Radimich ◽  
Grigoriy Vasil'yevich Adamov ◽  
Tamara Darizhapovna Dargaeva
Keyword(s):  
Phenolic Compounds ◽  
Secondary Metabolites ◽  
Scientific Research ◽  
Cichorium Intybus ◽  
Biologically Active ◽  
Qualitative Composition ◽  
Dominant Group ◽  
Phytochemical Study ◽  
Aerial Parts ◽  
In The Wild

The search for new plant species that are promising for use as a source of biologically active substances is an actual area of scientific research in the field of chemistry of natural compounds. The object of this study is the chicory (Cichorium intybus L.) The purpose of our scientific research is to conduct a comparative phytochemical study of the aerial parts of wild-growing and cultivated chicory to establish differences in the qualitative composition and content of secondary metabolites. As a result of studies by HPLC-MS, in the aerial part of a wild-growing plant, 10 compounds were identified esculletin, chicoriin, chicoric acid, chlorogenic acid, kaftaric acid, isochlorogenic A acid, caffeic acid, isoquercetin, astragalin, rutin. The dominant group of substances are oxycoumarins. The phenolic complex of the cultivated plant has a similar composition of secondary metabolites, however, its derivatives are hydroxycinnamic acid derivatives. The quantitative content of phenolic compounds in the wild-growing chicory herb was 2.56±0.12%, cultivated – 4.14±0.21%. Significant differences in the content and qualitative composition of phenolic compounds make it possible to use the chicory of a wild-growing and cultivated population to obtain pharmaceutical substances with various pharmacological effects.

Phytophenolics composition of Ocimum basilieum L. leaves methanol extract and its role in mitigating hypercholesterolemia in a rat model

2020 ◽  
Vol 16 ◽  
Author(s):  
Ali M. El-Hagrassi ◽  
Asmaa F. Aboul Naser ◽  
Abeer F. Osman ◽  
Manal A. Hamed
Keyword(s):  
Methanolic Extract ◽  
Density Lipoprotein ◽  
2D Nmr ◽  
Biologically Active ◽  
Lipoprotein Cholesterol ◽  
Fragmentation Pattern ◽  
Isolation And Identification ◽  
Phytochemical Study ◽  
Flavonoid Compounds ◽  
Liver And Kidney

Background:: Hypercholesterolemia is considered as one of the major risk factors for atherosclerosis. The study aimed to evaluate the effect of Ocimum basilieum L. against hypercholesterolemia in rats. Methods:: Isolation and identification of flavonoid compounds from the methanolic extract of Ocimum basilicum L. leaves were determined by UV, 1H, 13C-NMR and1D/2D NMR, HMBC and HMQC techniques. The biochemical evaluation was done through measuring total cholesterol (TC), high density lipoprotein -cholesterol (HDL-C), low density lipoprotein - cholesterol (LDL-C), triglycerides (TG), malondialdehyde (MDA), glutathione (GSH), total antioxidant capacity (TAC), aspartate and alanine aminotransferases (AST & ALT), alkaline phosphatase (ALP), urea, creatinine and albumin levels as well as DNA fragmentation pattern of kidneys. The histopathological features of liver and kidney were also examined. Results:: The phytochemical study revealed the presence of seven flavonoid compounds (apigenin-8-C-(α-L-rhamnopyranosyl- (1→2)-β-O –glucopyranoside (1), apigenin 6, 8-di-C-β-glucopyranoside (vicenin 2) (2), apigenin 7-O-(6''-O-trans-p-coumaryl)- β–glucopyranoside (3), apigenin 7-O-β-glucopyranoside (4), apigenin 8-C-β-glucopyranoside (vitexin) (5), apigenin -6-C-β- glucopyranoside (isovitexin) (6), apigenin (7)) and one phenolic compound; rosmarinic acid (8). Treatment with leaves extract at a dose of 250 mg/kg body weight for nine weeks simultaneously with oral cholesterol administration (30 mg/0.3 ml 0.7% tween/ animal) to rats fed with high fat diet restored all the biochemical parameters and the architectures of liver and kidney. Conclusion:: Ocimum basilieum leaves methanolic extract succeeded to act as a hypolipidemic, antioxidant and hepatorenal therapeutic agent due to its richness of biologically active phenolic and flavonoids compounds.

scholarly journals Isolation and Identification of the Five Novel Flavonoids from Genipa americana Leaves

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2521 ◽  
Author(s):  
Larissa Silva ◽  
Jovelina Alves ◽  
Emerson da Silva Siqueira ◽  
Manoel de Souza Neto ◽  
Lucas Abreu ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Medicinal Plant ◽  
Ethyl Acetate ◽  
Folk Medicine ◽  
Ethyl Acetate Fraction ◽  
Spectroscopic Methods ◽  
Isolation And Identification ◽  
1H And 13C Nmr ◽  
Chemical Structures ◽  
First Time

Genipa americana is a medicinal plant popularly known as “jenipapo”, which occurs in Brazil and belongs to the Rubiaceae family. It is a species widely distributed in the tropical Central and South America, especially in the Cerrado biome. Their leaves and fruits are used as food and popularly in folk medicine to treat anemias, as an antidiarrheal, and anti-syphilitic. Iridoids are the main secondary metabolites described from G. americana, but few studies have been conducted with their leaves. In this study, the aim was to chemical approach for identify the main compounds present at the extract of G. americana leaves. The powdered leaves were extracted by maceration with EtOH: water (70:30, v/v), following liquid-liquid partition with petroleum ether, chloroform, ethyl acetate and n-butanol. A total of 13 compounds were identified. In addition three flavonoids were isolated from the ethyl acetate fraction: quercetin-3-O-robinoside (GAF 1), kaempferol-3-O-robinoside (GAF 2) and isorhamnetin-3-O-robinoside (GAF 3) and, from n-butanol fraction more two flavonoids were isolated, kaempferol-3-O-robinoside-7-O-rhamnoside (robinin) (GAF 4) and isorhamnetin-3-O-robinoside-7-rhamnoside (GAF 5). Chemical structures of these five flavonoids were elucidated using spectroscopic methods (MS, 1H and 13C-NMR 1D and 2D). These flavonoids glycosides were described for the first time in G. americana.

scholarly journals Phytochemistry, Pharmacology and Medicinal Uses of Plants of the Genus Salix: An Updated Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Nora Tawfeek ◽  
Mona F. Mahmoud ◽  
Dalia I Hamdan ◽  
Mansour Sobeh ◽  
Nawaal Farrag ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Salicylic Acid ◽  
Chemical Composition ◽  
Secondary Metabolites ◽  
Folk Medicine ◽  
Phenolic Glycosides ◽  
Biologically Active ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Current Review

The Willows (genus Salix), with more than 330–500 species and 200 hybrids, are trees, shrubs or prostrate plants that are widely distributed in Africa, North America, Europe, and Asia. The genus is traditionally used in folk medicine and represents a valuable source of biologically active compounds among them salicin, a prodrug for salicylic acid. Altogether, 322 secondary metabolites were characterized in the genus including flavonoids 94) (flavonols, flavones, flavanones, isoflavones, flavan-3-ols (catechins and procyanidins), chalcones, dihydrochalcone, anthocyanins, dihydroflavonols), phenolic glycosides (76), organic acids (28), and non-phenolic glycosides (17), sterols and terpenes (17), simple phenolics 13) and lignans 7) in addition to volatiles and fatty acids (69). Furthermore, willows exert analgesic, anti-inflammatory, antioxidant, anticancer, cytotoxic, antidiabetic, antimicrobial, antiobesity, neuroprotective and hepatoprotective activities. The current review provides an updated summary of the importance of willows, their chemical composition and pharmacological activities.

scholarly journals Isolation, diversity, and antimicrobial activity of fungal endophytes from Rohdea chinensis (Baker) N.Tanaka (synonym Tupistra chinensis Baker) of Qinling Mountains, China

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e9342
Author(s):  
Chao An ◽  
Saijian Ma ◽  
Xinwei Shi ◽  
Wenjiao Xue ◽  
Chen Liu ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Liquid Chromatography ◽  
Secondary Metabolites ◽  
Endophytic Fungi ◽  
High Performance ◽  
Fungal Endophytes ◽  
Folk Medicine ◽  
Antimicrobial Activities ◽  
Biologically Active ◽  
Qinling Mountains

Endophytic fungi have been emerged as fruitful resources for producing structurally fascinating and biologically active secondary metabolites. However, endophytic fungi from medicinal plants of Qinling Mountains–the most important natural climatic boundary between the subtropical and warm temperate zones of China with an astonishingly high level of biodiversity–have rarely been explored as potential sources of novel fungal species and active secondary metabolites. In this study, a total of 371 fungal colonies were successfully isolated from 510 tissue segments of the medicinal Tupistra chinensis Baker collected from Qinling Mountains, China. Roots of T. chinensis Baker are used as a folk medicine to ameliorate pharyngitis and treat rheumatic diseases. A total of 100 representative morphotype strains were identified according to ITS rDNA sequence analyses and were grouped into three phyla (Ascomycota, Basidiomycota, Mucoromycota), seven classes (Dothideomycetes, Sordariomycetes, Eurotiomycetes, Microbotryomycetes, Agaricomycetes, Leotiomycetes, Mortierellomycetes), and at least 35 genera. The genera of Collectotrichum (IF, 29.92%), Fusarium (IF, 8.36%), Aspergillus (IF, 8.09%), and Dactylonectria (IF, 5.39%) were most frequently isolated from the tissues of T. chinensis Baker. The Species Richness Index (S, 65) and the Shannon-Wiener Index (H′, 3.7914) indicated that T. chinensis Baker harbored abundant fungal resources. Moreover, five isolates were potential new taxa because of low similarity of ITS sequences ranged from 95.09%∼96.61%. Fifteen out of 100 endophytic fungal ethyl acetate extracts exhibited inhibitory activities against at least one pathogenic bacterium or fungus. Two important lead compounds produced by two stains (F8047 and F8075) with high antimicrobial activities were identified using high performance liquid chromatography (HPLC) and ultra-performance liquid chromatography-quadrupole-time of flight mass spectrometry (UPLC–QTOF MS) analyses. In addition, it was noteworthy that the strain F8001, which may be a potential new species, showed antimicrobial activity and should be investigated further. Overall, these results indicated that the endophytic fungi from T. chinensis Baker could be exploited as a novel source of bioactive compounds.

Isolation of secondary metabolites from the Iranian medicinal plant Eremurus persicus

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Javad Mottaghipisheh ◽  
Norbert Kúsz ◽  
Judit Hohmann ◽  
Yu-Chi Tsai ◽  
Dezső Csupor
Keyword(s):  
Secondary Metabolites ◽  
Medicinal Plant ◽  
Methyl Ether ◽  
Crude Extract ◽  
Folk Medicine ◽  
Isolation And Identification ◽  
Widespread Application ◽  
Chromatographic Techniques ◽  
Endemic Medicinal Plant ◽  
First Time

AbstractEremurus persicus (Jaub. & Spach) Boiss. belonging to Xanthorrhoeaceae family is an endemic medicinal plant widely distributed in Iran. Its leaves have been traditionally used as a food and also as medicinal plant. Regarding the widespread application of E. persicus in Iranian folk medicine, and the insignificant investigation of its components, this study aimed at the isolation and identification of major secondary metabolites of this plant. By applying various chromatographic techniques, corchoionoside A (1), 4-amino-4-carboxychroman-2-one (2), isoorientin (3), ziganein 5-methyl ether (4), auraptene (5), and imperatorin (6) were isolated from the EtOAc and CHCl3 fractions of the crude extract. Except isoorientin (3), all the identified phytoconstituents were reported for the first time from Eremurus genus.

scholarly journals COMPONENTS OF ARTEMISIA SOGDIANA

2020 ◽  
pp. 207-214
Author(s):  
Rimma Fail'yevna Mukhamatkhanova ◽  
Khayrulla Mamadievich Bobakulov ◽  
Il'dar Dzhamil'yevich Sham’yanov ◽  
Rasul Yangiberdievich Оkmanov ◽  
Haji Akber Aisa ◽  
...  
Keyword(s):  
Pharmaceutical Industry ◽  
Secondary Metabolites ◽  
Aerial Part ◽  
Sesquiterpene Lactones ◽  
Biologically Active ◽  
Phytochemical Study ◽  
Alcohol Extract ◽  
Effective Use ◽  
Medicinal Flora ◽  
First Time

Phytochemical research and effective use of medicinal flora in the future create the basis for the development of the domestic pharmaceutical industry and allow not only to fill the deficit of drugs, but also contribute to the development of new, environmentally friendly and a number of qualities of unique, export-oriented preparations. The plants of the genus Artemisia L. are rich sources of biologically active secondary metabolites. Phytochemical study of secondary metabolites of plants of the genus Artemisia has led to the creation on their basis, in particular, on the sesquiterpene lactones, antitumor (Artemisinin and its derivatives; Arglabin), antiatherosclerotic (Leucomisin (preparation Oligvon)), cardiotonic (Tauremisin), anthelmintic (α-Santonin) and antimalarial (Artemisinin and its derivatives) preparations. In order to search for natural biologically active compounds, we studied the components of the alcohol extract of the aerial part of Artemisia sogdiana Bunge, collected during budding in the Zaamin district of the Jizzakh region of Uzbekistan. The result of phytochemical research for the first time from this plant is isolated a phenolic compound xanthoxylin, sesquiterpene lactone artesin, flavonoids genkwanin and eupatilin, the structure of which is established on the basis of spectral data.

scholarly journals INVESTIGATION OF FLAVONOIDS OF THE ROOT OF THE PLANT SCUTELLARIA INTERMEDIA POPOV

2018 ◽  
pp. 89-94 ◽  
Author(s):  
Абдурашид (Abdurashid) Мусахонович (Musahonovich) Каримов (Karimov) ◽  
Антон (Anton) Сергеевич (Sergeevich) Попков (Popkov) ◽  
Юлия (Yuliya) Владимировна (Vladimirovna) Остроушко (Ostroushko) ◽  
Румия (Rumiya) Исаевна (Isaevna) Туртаева (Turtaeva) ◽  
Эркин (Erkin) Хожиакбарович (Hozyakbarovich) Ботиров (Botirov)
Keyword(s):  
Mass Spectra ◽  
Folk Medicine ◽  
Ethanol Extract ◽  
Biologically Active ◽  
Ethyl Glucuronide ◽  
Pharmacological Properties ◽  
Chemical Transformations ◽  
Phytochemical Study ◽  
Tropical Regions ◽  
Physicochemical Constants

Plants of the genus Scutellaria L. – the skullcap (the Lamiaceae family) on the globe are represented by 360 species, widespread in temperate, subtropical and tropical regions, including Europe, North America and East Asia. They are used in folk medicine and are a source of unique biologically active compounds with valuable pharmacological properties. The article is devoted to the phytochemical study of the flavonoids of the roots of S. intermedia. From the ethyl acetate and n-butanol fractions of the 80% ethanol extract of the roots, 6 flavonoids were first isolated. Based on the results of chemical transformations, UV, 1H, 13C NMR and mass spectra, comparison of physicochemical constants with literature data, and comparison with samples of flavonoids isolated from other species of Scutellaria L., the compounds obtained wogonine, 5,8-dihydroxy-7-methoxyflavone, 5,7,4'-trihydroxy-6-methoxyflavanone (dihydrohispidulin) 5,6,7,4'-tetrahydro- xiflavane (dihydroscutellarein), luteoline and baicalein 7-O-β-D-ethyl glucuronide.

scholarly journals Qualitative and quantitative analysis of the content of phenolic compounds and their derivatives in the rhizome of Panax vietnamensis Ha et Grushv

2019 ◽  
Vol 58 (5) ◽  
pp. 39-43
Author(s):  
Roman O. Grigoryev ◽  
◽  
Nadezhda K, Chirikova ◽  
Daniil N. Olennikov ◽  
◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Secondary Metabolites ◽  
Folk Medicine ◽  
Population Based ◽  
Consumer Products ◽  
Biologically Active ◽  
Wide Range ◽  
Ancient Times ◽  
Unique Composition

Since ancient times, it is known that all types of ginseng were widely used in Eastern folk medicine as a cure for many diseases. All species of the genus Panax, including Panax vietnamensis, contain saponins, but the phenolic composition has not been studied to date. Vietnamese ginseng is characterized by a unique composition of triterpene glycosides, among which the glycosylated derivatives of the rare triterpene aglycone, okothylol, are predominant. It is the only evergreen among ginsengs. As you know, a single plant can have different types of biological activity due to the content of different groups of biologically active compounds with a wide range of physicochemical properties and causing different pharmacological effects. Obviously, phenolic compounds along with other secondary metabolites in Panax vietnamensis have a phytotherapeutic effect on the human body. The purpose of this work is to expand the knowledge of the scientific community about the synthesized compounds, in particular about phenolic compounds that accumulate in the rhizomes of Panax vietnamensis. In this paper, the results of a study on the qualitative (method HPLC-DMD-MS) and quantitative content of phenolic compounds (Folin-Cicalteu method) of the roots of Panax vietnamensis were presented for the first time. These results can be very interesting for scientists involved in the synthesis of secondary metabolites, growing callus and suspension cell cultures in vitro ginseng and other ginseng species, as well as for pharmaceutical and cosmetic companies producing various consumer products for the population based on Vietnamese ginseng. This work will expand the scientific community’s knowledge of secondary metabolites synthesized by the rhizome Panax vietnamensis Ha et Grushv.

Sign in / Sign up

Export Citation Format

Share Document