scholarly journals Effects of high dose olive leaf extract on haemodynamic and oxidative stress parameters in normotensive and spontaneously hypertensive rats

2014 ◽  
Vol 79 (9) ◽  
pp. 1085-1097 ◽  
Author(s):  
Dragana Dekanski ◽  
Nevena Mihailovic-Stanojevic ◽  
Grujic Milanovic ◽  
Djurdjica Jovovic ◽  
Zoran Miloradovic
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Glutathione Reductase ◽  
Spontaneously Hypertensive Rats ◽  
Leaf Extract ◽  
High Dose ◽  
Olive Leaf ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Olive Leaf Extract

Antihypertensive activity of natural antioxidant, olive leaf extract (OLE) is known, but its influence on cardiovascular system when administered in a high dose has not been investigated yet. Our aim was to determine the acute effects of excessive intake of standardized OLE on blood pressure, heart rate and oxidative status in both spontaneously hypertensive rats and normotensive Wistar rats. Systolic arterial pressure and heart rate were measured using a tail-cuff, pneumatic pulse detector, before, 60 and 120 minutes after intragastric OLE administration. Activities of catalase, glutathione peroxidase, superoxide dismutase (SOD) and glutathione reductase in erythrocytes, as well as lipid peroxidation in plasma (pTBARS) were measured at the same time points, spectrophotometrically. High-dose OLE did not influence blood pressure, heart rate and pTBARS in normotensive rats, while SOD, catalase, and glutathione reductase activities significantly increased. The same dose significantly decreased blood pressure in hypertensive rats, but increased pTBARS and SOD activity. Excessive oral intake of OLE induced moderate hypotensive effects in spontaneously hypertensive rats only, suggesting absence of harmful haemodynamic effects after oral overdose in both rats strain. However, its prooxidative role when given in high dose in hypertensive organism should not be neglected.

Antihypertensive effects of oleuropein-enriched olive leaf extract in spontaneously hypertensive rats

2016 ◽  
Vol 7 (1) ◽  
pp. 584-593 ◽  
Author(s):  
M. Romero ◽  
M. Toral ◽  
M. Gómez-Guzmán ◽  
R. Jiménez ◽  
P. Galindo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Endothelial Function ◽  
Spontaneously Hypertensive Rats ◽  
Leaf Extract ◽  
Olive Leaf ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Olive Leaf Extract ◽  
Inflammatory Status

The effects of chronic consumption of oleuropein-enriched (15% w/w) olive leaf extract (OLE) on blood pressure, endothelial function, and vascular oxidative and inflammatory status in spontaneously hypertensive rats (SHR) were evaluated.

Regression of myocardial hypertrophy and influence of adrenergic system

1983 ◽  
Vol 244 (1) ◽  
pp. H97-H101 ◽  
Author(s):  
S. Sen ◽  
R. C. Tarazi
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Regression Analysis ◽  
Arterial Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Myocardial Hypertrophy ◽  
Cardiac Response ◽  
Adrenergic System ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Studies of regression of myocardial hypertrophy in spontaneously hypertensive rats (SHR) suggest that the adrenergic system may play an important role in the reversal of hypertrophy. The effect of propranolol on reversal of hypertrophy, however, is still controversial. This study describes the effect of propranolol, given alone or in combination with hydralazine in different ratios for 4 wk, on blood pressure (BP), ventricular weight, and myocardial catecholamine (MC) concentrations. The data show that a certain ratio of propranolol to hydralazine (750:30) leads to moderate BP control (196-156 mmHg) without increased MC (634 vs. 552 ng/g) and moderately reduced hypertrophy. Reduction of BP alone with increased MC (hydralazine alone) or reduction of MC without BP control (propranolol alone) failed to reduce hypertrophy. A significant correlation between both ventricular weight and heart rate with MC (r = 0.6) was obtained by multiple regression analysis. This study suggests that adrenergic factors seem to play an important role in modulating structural cardiac response to variations in arterial pressure.

scholarly journals Effects of Concentrated Ambient Particles on Heart Rate, Blood Pressure, and Cardiac Contractility in Spontaneously Hypertensive Rats

2004 ◽  
Vol 16 (6-7) ◽  
pp. 421-429 ◽  
Author(s):  
Chuen-Chau Chang ◽  
Jing-Shiang Hwang ◽  
Chang-Chuan Chan ◽  
Peng-Yau Wang ◽  
Tsuey-Hwa Hu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Spontaneously Hypertensive Rats ◽  
Cardiac Contractility ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Ambient Particles
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