scholarly journals Gestational choriocarcinoma with hemorrhagic pleural effusion

2010 ◽  
Vol 18 (3) ◽  
pp. 86-87
Author(s):  
Biljana Lazovic ◽  
Vera Milenkovic
Keyword(s):  
Pleural Effusion ◽  
Blood Vessels ◽  
Gestational Trophoblastic Disease ◽  
Common Site ◽  
Left Half ◽  
Trophoblastic Disease ◽  
Gestational Choriocarcinoma ◽  
Hemorrhagic Pleural Effusion ◽  
Timely Treatment ◽  
Trophoblastic Tissue

Gestational trophoblastic disease (GTD) consists of a spectrum of disorders that are characterized by an abnormal proliferation of trophoblastic tissue. By virtue of their high vascularity and affinity of trophoblast for blood vessels, metastases often occur early and the most common site of such metastases is the lung. We described a case of a 34-year-old patient with pain in the left half of the chest, occasional, brief hemoptysis, and amenorrhea occurring in the period of 3 months. This presentation highlights the importance of analysis of HCG in the pleural puncture, for quick diagnosis and timely treatment.

scholarly journals Significance of transvaginal Doppler ultrasonography for detection of malignant gestational trophoblastic disease

2005 ◽  
Vol 62 (2) ◽  
pp. 103-105 ◽  
Author(s):  
Branka Nikolic ◽  
Snezana Rakic ◽  
Dejan Pavlovic ◽  
Svetlana Popovac ◽  
Relja Lukic
Keyword(s):  
Early Detection ◽  
Blood Vessels ◽  
Doppler Ultrasonography ◽  
Resistance Index ◽  
Gestational Trophoblastic Disease ◽  
Uterine Wall ◽  
Uterine Tissue ◽  
Trophoblastic Disease ◽  
Trophoblastic Tissue

Transvaginal Doppler ultrasonography has an important role in detecting and confirming the gestational trophoblastic disease (GTD). It can also be helpful in early detection of the malignant cases of GTD such as the invasion and protrusion of trophoblastic tissue into the uterine wall. Ultrasonographic picture of the malignant GTD is also specific for the presence of prominent zones of vasculavization in the peritrophoblastic tissue, as well as in the uterine tissue in which malignant GTD is developed. Resistance Index (RI) values were measured at the level of blood vessels of peritrophoblastic tissue and of suspected zones in the uterine tissue to detect neovascularization, which followed the malignant process. Theca luteal cysts were often detected by Transvaginal Doppler ultrasonography.

scholarly journals Primary tubal choriocarcinoma

2018 ◽  
Vol 7 (6) ◽  
pp. 2509
Author(s):  
Neetha Nandan ◽  
Kishan Prasad ◽  
Mubeena Begum ◽  
Supriya Rai
Keyword(s):  
Adjuvant Chemotherapy ◽  
Ectopic Pregnancy ◽  
Malignant Transformation ◽  
Histopathological Examination ◽  
Gestational Trophoblastic Disease ◽  
Common Site ◽  
Chorionic Villi ◽  
Trophoblastic Disease ◽  
Aggressive Form ◽  
Β Hcg

Choriocarcinoma is extremely aggressive form of gestational trophoblastic disease. It occurs due to neoplastic changes in the chorionic villi. The most common site of origin is uterus but rarely can occur in tube, cervix or ovary. Tubal choriocarcinoma may develop either by malignant transformation of a tubal pregnancy or can arise denovo without an ectopic pregnancy. The reported incidence of tubal choriocarcinoma is approximately 1.5/1,000,000 births. Here, we report a case in which salphingectomy was done thinking it was an acute ectopic pregnancy, but histopathological examination showed tubal choriocarcinoma. This tubal choriocarcinoma occurred denovo and was not secondary to an ectopic pregnancy. Patient did not need adjuvant chemotherapy as it was detected early and is being followed up by β-hcg monitoring.

scholarly journals Understanding and management of gestational trophoblastic disease

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 428 ◽  
Author(s):  
Fen Ning ◽  
Houmei Hou ◽  
Abraham N. Morse ◽  
Gendie E. Lash
Keyword(s):  
Risk Factors ◽  
Treatment Options ◽  
Gestational Trophoblastic Disease ◽  
Abnormal Development ◽  
Trophoblastic Disease ◽  
Trophoblastic Tissue

Gestational trophoblastic disease or neoplasia covers a spectrum of benign and malignant conditions arising from pregnancies with highly abnormal development of trophoblastic tissue. In this brief review, we discuss the different features of these different conditions and their origins and risk factors and introduce some of the more novel and controversial treatment options currently being explored.

scholarly journals Coriocarcinoma gestacional primario de cuello uterino. Presentación de un caso

2021 ◽  
Vol 81 (04) ◽  
pp. 406-410
Author(s):  
Viviana García ◽  
◽  
Franco Calderaro Di Ruggiero ◽  
Jorge Hoegl ◽  
Carlos Quintero ◽  
...  
Keyword(s):  
Abnormal Uterine Bleeding ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Gestational Trophoblastic Disease ◽  
World Health ◽  
Molar Pregnancy ◽  
Trophoblastic Disease ◽  
Gestational Choriocarcinoma ◽  
Gynecology And Obstetrics ◽  
Gynecological Examination

Choriocarcinoma represents a type of malignant tumor of gestational trophoblastic disease. It can develop after a molar pregnancy, miscarriage, normal or ectopic pregnancy. Generally its seat site is the uterine body; infrequent places such as the cervix have been described. We report the case of a 37-year-old patient is reported, VI gestations IV deliveries I cesarean section I molar pregnancy, with abnormal uterine bleeding, which is referred to the Hospital Oncology Service. On gynecological examination, an exophytic mass is observed in the cervix. A biopsy was taken that reported: Gestational choriocarcinoma and plasma levels of β-hCG were verified: 13805 IU / L. A total abdominal hysterectomy was performed with preservation of the ovaries. It was concluded as stage I of the International Federation of Gynecology and Obstetrics and 8, according to the score of the World Health Organization (ST I: 8), for which adjuvant was indicated. Currently no evidence of disease. Keywords: Choriocarcinoma, gestational trophoblastic disease, cervix.

scholarly journals Fluorescence In Situ Hybridization for the X and Y Chromosome Centromeres Helps Differentiate Between Gestational and Nongestational Choriocarcinoma in Clinically Ambiguous Cases

2019 ◽  
Vol 144 (7) ◽  
pp. 863-868
Author(s):  
Rumeal D. Whaley ◽  
Rachel E. Dougherty ◽  
Liang Cheng ◽  
Thomas M. Ulbright
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Y Chromosome ◽  
Genetic Material ◽  
Gestational Trophoblastic Disease ◽  
Definitive Diagnosis ◽  
Molecular Genotyping ◽  
Trophoblastic Disease ◽  
Gestational Choriocarcinoma

Context.— Gestational choriocarcinoma usually presents during the reproductive years, typically within 1 year of pregnancy, although presentation remote from pregnancy also occurs and may cause confusion with other tumors, including choriocarcinoma of germ cell origin and somatic carcinomas with choriocarcinomatous differentiation. It is important to separate these tumors for treatment and prognostic reasons. Objective.— To assess the utility of fluorescence in situ hybridization for the X and Y chromosome centromeres in determining the gestational origin of clinically ambiguous extrauterine choriocarcinomas in women. Design.— A review of female patients with extrauterine choriocarcinomas who had no evidence of prior gestational trophoblastic disease was performed. Samples were analyzed by fluorescence in situ hybridization for the X and Y chromosome centromeres using standard methodologies. Results.— Five cases met the criteria, all of which displayed trophoblastic cells and necrosis. Three cases (60%) had Y chromosomes by fluorescence in situ hybridization, which confirmed gestational origin. Although the 2 cases without a Y chromosome would ordinarily require molecular genotyping for paternal genetic material to establish gestational origin, in one of these cases a subsequent recurrence of yolk sac tumor allowed confirmation of its mediastinal origin. Conclusions.— Fluorescence in situ hybridization for detection of the X and Y chromosome centromeres is an effective screening test for gestational choriocarcinoma. It provided a definitive diagnosis of metastatic gestational choriocarcinoma in 3 of 5 potential cases that lacked a clinical history of gestational trophoblastic disease. An additional benefit is that more laboratories have the capability to perform fluorescence in situ hybridization than can perform molecular genotyping for definitive diagnosis.

scholarly journals Does hysteroscopy in women with persistent gestational trophoblastic disease reduce the need for chemotherapy? A prospective, single-arm, clinical trial pilot study

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Fatemeh Davari Tanha ◽  
Saghar Samimi Sede ◽  
Fariba Yarandi ◽  
Elham Shirali ◽  
Maliheh Fakehi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Hydatidiform Mole ◽  
Gestational Trophoblastic Disease ◽  
Trophoblastic Disease ◽  
Beta Hcg ◽  
Significant Difference ◽  
History Of ◽  
The Mean ◽  
Trophoblastic Tissue

Abstract Background This study aimed to describe the efficacy of hysteroscopy in the management of women with the persistent gestational trophoblastic disease (PGTD)/GTN to reduce the need for chemotherapy. Materials and methods This prospective, single-arm, clinical trial study was recruited in an educational referral hospital between September 2018 and September 2019. Totally, 30 participants with a history of hydatidiform mole that was managed by uterine evacuation and developed low risk persistent gestational trophoblastic disease were recruited. Hysteroscopy was performed for removal of persisted trophoblastic tissue. Serum beta-hCG titer was measured before and 7 days after the procedure. Results The mean ± SD age of the participants was 31.4 ± 4.6 years. There was a significant difference (p = 0.06) between that mean ± SD of beta-hCG titer before (8168.4 ± 1758) and after (2648.8 ± 5888) hysteroscopy. Only two (6.6%) cases underwent chemotherapy due to no drop in the beta-hCG titer. Conclusion Hysteroscopy may play a significant role in the management of GTN, although it requires validation in larger prospective randomized studies and longer follow-up.

scholarly journals Does Hysteroscopy in Women with Persistent Gestational Trophoblastic Disease Reduce the Need for Chemotherapy? A Prospective, Single Arm, Clinical Trial Pilot Study

2020 ◽  
Author(s):  
Fatemeh Davari Tanha ◽  
Saghar Samimi Sede ◽  
Fariba Yarandi ◽  
Elham Shirali ◽  
Malihe Fakehi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Pilot Study ◽  
Significant Role ◽  
Hydatidiform Mole ◽  
Gestational Trophoblastic Disease ◽  
Low Risk ◽  
Trophoblastic Disease ◽  
Beta Hcg ◽  
Trophoblastic Tissue

Abstract Background: This study aimed to describe the efficacy of hysteroscopy in the management of women with persistent gestational trophoblastic disease to decrease the chemotherapy need.Materials and methods: This prospective, single-arm, clinical trial study was conducted at a tertiary educational referral hospital between September 2018 and September 2019. In the follow-up of the patients diagnosed with hydatidiform mole and managed by uterine evacuation, 30 cases developed low risk persistent gestational trophoblastic disease. Hysteroscopy was performed for removal of persisted trophoblastic tissue, before chemotherapy. Serum beta-hCG titer was measured before and 7 days after the procedure.Results: Mean±SD age of the participants was 31.4±4.6 years. There was a significantly difference (p=0.06) between that mean±SD of beta-hCG titer before (8168.4±1758) and after (2648.8±5888) treatment. Two (6.6%) cases needed chemotherapy due to no decrease in beta-hCG titer. Conclusion: Although, hysteroscopy may play a significant role in the management of persistent gestational trophoblastic disease but requires validation in larger prospective randomized studies and longer follow-up.

scholarly journals Gestational Tubal Choriocarcinoma Presenting as a Pregnancy of Unknown Location following Ovarian Induction

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Lawrence Hsu Lin ◽  
Koji Fushida ◽  
Eliane Azeka Hase ◽  
Regina Schultz ◽  
Laysa Manatta Tenorio ◽  
...  
Keyword(s):  
Fallopian Tube ◽  
Rare Case ◽  
Early Recognition ◽  
Final Diagnosis ◽  
Gestational Trophoblastic Disease ◽  
Trophoblastic Disease ◽  
Gestational Choriocarcinoma ◽  
Ovarian Induction ◽  
Challenging Situation ◽  
Pregnancy Of Unknown Location

The management of pregnancy of unknown location (PUL) can be a challenging situation, since it can present as several different conditions. Here we describe a rare case of gestational choriocarcinoma arising in the fallopian tube after ovarian induction in an infertile patient. The patient received clomiphene for ovarian induction and had rising levels of human chorionic gonadotropin (hCG) over nine months without sign of pregnancy. After referral to our center, the patient was diagnosed with a paraovarian tumor, which revealed a gestational choriocarcinoma arising in the fallopian tube; the final diagnosis was supported by pathological and cytogenomic analysis. Malignancies, such as gestational trophoblastic disease, should be in the differential diagnosis of PUL; the early recognition of these conditions is key for the proper treatment and favorable outcome.

Malignant disease in pregnancy

2010 ◽  
pp. 2181-2185
Author(s):  
Robin A.F. Crawford
Keyword(s):  
Hydatidiform Mole ◽  
Gestational Trophoblastic Disease ◽  
Molar Pregnancy ◽  
Live Births ◽  
Trophoblastic Disease ◽  
Gestational Choriocarcinoma ◽  
Placental Site ◽  
Cancer In Pregnancy ◽  
Malignant Trophoblast ◽  
In Pregnancy

Cancer in pregnancy is rare, affecting less than 1 in 1000 live births. It may be specific to pregnancy (gestational trophoblastic disease) or incidental to it, the less infrequent conditions being melanoma, lymphoma, and cervical malignancy. Gestational trophoblastic disease—a group of conditions that arise in the fetal chorion during various types of pregnancy: histologically they are categorized as (1) partial or complete hydatidiform mole, (2) gestational choriocarcinoma, or (3) placental site trophoblastic tumour. The most common of these conditions is molar pregnancy, when villi are present in association with malignant trophoblast in gestational choriocarcinoma....

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