scholarly journals Gestational Tubal Choriocarcinoma Presenting as a Pregnancy of Unknown Location following Ovarian Induction

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Lawrence Hsu Lin ◽  
Koji Fushida ◽  
Eliane Azeka Hase ◽  
Regina Schultz ◽  
Laysa Manatta Tenorio ◽  
...  
Keyword(s):  
Fallopian Tube ◽  
Rare Case ◽  
Early Recognition ◽  
Final Diagnosis ◽  
Gestational Trophoblastic Disease ◽  
Trophoblastic Disease ◽  
Gestational Choriocarcinoma ◽  
Ovarian Induction ◽  
Challenging Situation ◽  
Pregnancy Of Unknown Location

The management of pregnancy of unknown location (PUL) can be a challenging situation, since it can present as several different conditions. Here we describe a rare case of gestational choriocarcinoma arising in the fallopian tube after ovarian induction in an infertile patient. The patient received clomiphene for ovarian induction and had rising levels of human chorionic gonadotropin (hCG) over nine months without sign of pregnancy. After referral to our center, the patient was diagnosed with a paraovarian tumor, which revealed a gestational choriocarcinoma arising in the fallopian tube; the final diagnosis was supported by pathological and cytogenomic analysis. Malignancies, such as gestational trophoblastic disease, should be in the differential diagnosis of PUL; the early recognition of these conditions is key for the proper treatment and favorable outcome.

scholarly journals A Rare Case of Intrauterine Adhesion Caused by Intrauterine Fallopian Tube Incarceration

2021 ◽  
pp. 64-67
Author(s):  
Yiran Liu ◽  
Yugang Chi
Keyword(s):  
Fallopian Tube ◽  
Rare Case ◽  
Early Recognition ◽  
Uterine Cavity ◽  
Uterine Perforation ◽  
Secondary Infertility ◽  
False Passage ◽  
Intrauterine Adhesion ◽  
Tubal Lumen ◽  
The Right

Hysteroscopy is widely used for the detection and treatment of intrauterine adhesion. Such technique, however, sometimes has limitations and even second damages. We report a rare case of severe intrauterine adhesion caused by uterine perforation with a fallopian tube incarceration. A 24-year-old woman underwent severe intrauterine adhesion and secondary infertility caused by fallopian tube incaceration into the uterine cavity after postpartum curettage. First hysteroscopy created a false passage through the previous uterine perforation, entered into the cavity of incarcerated fallopian tube, and led to iatrogenic hydrosalpinx. Secondary hysteroscopy combined with laparoscopy revealed a connection between the right tubal lumen and the uterine cavity by the false passage, released the adhesion, and reconstructed the uterine cavity. Early recognition of uterine perforation or tissue incarcerarion is significant in preventing further damage.

scholarly journals Coriocarcinoma gestacional primario de cuello uterino. Presentación de un caso

2021 ◽  
Vol 81 (04) ◽  
pp. 406-410
Author(s):  
Viviana García ◽  
◽  
Franco Calderaro Di Ruggiero ◽  
Jorge Hoegl ◽  
Carlos Quintero ◽  
...  
Keyword(s):  
Abnormal Uterine Bleeding ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Gestational Trophoblastic Disease ◽  
World Health ◽  
Molar Pregnancy ◽  
Trophoblastic Disease ◽  
Gestational Choriocarcinoma ◽  
Gynecology And Obstetrics ◽  
Gynecological Examination

Choriocarcinoma represents a type of malignant tumor of gestational trophoblastic disease. It can develop after a molar pregnancy, miscarriage, normal or ectopic pregnancy. Generally its seat site is the uterine body; infrequent places such as the cervix have been described. We report the case of a 37-year-old patient is reported, VI gestations IV deliveries I cesarean section I molar pregnancy, with abnormal uterine bleeding, which is referred to the Hospital Oncology Service. On gynecological examination, an exophytic mass is observed in the cervix. A biopsy was taken that reported: Gestational choriocarcinoma and plasma levels of β-hCG were verified: 13805 IU / L. A total abdominal hysterectomy was performed with preservation of the ovaries. It was concluded as stage I of the International Federation of Gynecology and Obstetrics and 8, according to the score of the World Health Organization (ST I: 8), for which adjuvant was indicated. Currently no evidence of disease. Keywords: Choriocarcinoma, gestational trophoblastic disease, cervix.

scholarly journals Fluorescence In Situ Hybridization for the X and Y Chromosome Centromeres Helps Differentiate Between Gestational and Nongestational Choriocarcinoma in Clinically Ambiguous Cases

2019 ◽  
Vol 144 (7) ◽  
pp. 863-868
Author(s):  
Rumeal D. Whaley ◽  
Rachel E. Dougherty ◽  
Liang Cheng ◽  
Thomas M. Ulbright
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Y Chromosome ◽  
Genetic Material ◽  
Gestational Trophoblastic Disease ◽  
Definitive Diagnosis ◽  
Molecular Genotyping ◽  
Trophoblastic Disease ◽  
Gestational Choriocarcinoma

Context.— Gestational choriocarcinoma usually presents during the reproductive years, typically within 1 year of pregnancy, although presentation remote from pregnancy also occurs and may cause confusion with other tumors, including choriocarcinoma of germ cell origin and somatic carcinomas with choriocarcinomatous differentiation. It is important to separate these tumors for treatment and prognostic reasons. Objective.— To assess the utility of fluorescence in situ hybridization for the X and Y chromosome centromeres in determining the gestational origin of clinically ambiguous extrauterine choriocarcinomas in women. Design.— A review of female patients with extrauterine choriocarcinomas who had no evidence of prior gestational trophoblastic disease was performed. Samples were analyzed by fluorescence in situ hybridization for the X and Y chromosome centromeres using standard methodologies. Results.— Five cases met the criteria, all of which displayed trophoblastic cells and necrosis. Three cases (60%) had Y chromosomes by fluorescence in situ hybridization, which confirmed gestational origin. Although the 2 cases without a Y chromosome would ordinarily require molecular genotyping for paternal genetic material to establish gestational origin, in one of these cases a subsequent recurrence of yolk sac tumor allowed confirmation of its mediastinal origin. Conclusions.— Fluorescence in situ hybridization for detection of the X and Y chromosome centromeres is an effective screening test for gestational choriocarcinoma. It provided a definitive diagnosis of metastatic gestational choriocarcinoma in 3 of 5 potential cases that lacked a clinical history of gestational trophoblastic disease. An additional benefit is that more laboratories have the capability to perform fluorescence in situ hybridization than can perform molecular genotyping for definitive diagnosis.

scholarly journals Gestational choriocarcinoma with hemorrhagic pleural effusion

2010 ◽  
Vol 18 (3) ◽  
pp. 86-87
Author(s):  
Biljana Lazovic ◽  
Vera Milenkovic
Keyword(s):  
Pleural Effusion ◽  
Blood Vessels ◽  
Gestational Trophoblastic Disease ◽  
Common Site ◽  
Left Half ◽  
Trophoblastic Disease ◽  
Gestational Choriocarcinoma ◽  
Hemorrhagic Pleural Effusion ◽  
Timely Treatment ◽  
Trophoblastic Tissue

Gestational trophoblastic disease (GTD) consists of a spectrum of disorders that are characterized by an abnormal proliferation of trophoblastic tissue. By virtue of their high vascularity and affinity of trophoblast for blood vessels, metastases often occur early and the most common site of such metastases is the lung. We described a case of a 34-year-old patient with pain in the left half of the chest, occasional, brief hemoptysis, and amenorrhea occurring in the period of 3 months. This presentation highlights the importance of analysis of HCG in the pleural puncture, for quick diagnosis and timely treatment.

scholarly journals A rare case report of gestational trophoblastic disease in peri menopausal women

2020 ◽  
Vol 9 (11) ◽  
pp. 4716
Author(s):  
Nagashree U. ◽  
Wahida Suresh
Keyword(s):  
Early Recognition ◽  
Gestational Trophoblastic Disease ◽  
Reproductive Age ◽  
Trophoblastic Disease ◽  
Menopausal Women ◽  
Rare Case Report ◽  
Abnormal Bleeding ◽  
Post Menopausal ◽  
Reproductive Age Group

Benign gestational trophoblastic disease (GTD) generally occurs in reproductive age group women; but is extremely rare in peri and post-menopausal women. We report a case of molar pregnancy in a 48-year-old lady with complaints of bleeding per vaginum with severe pain abdomen. The intention was to highlight the need to include GTD as a possible cause of abnormal bleeding per vaginum in peri and post-menopausal women. So early diagnosis and management with proper follow up is possible. It stresses the need for early recognition to avoid high malignant sequelae.

scholarly journals Twin pregnancy with complete hydatiform mole and coexisting live fetus: A rare case report

2019 ◽  
pp. 31-34
Author(s):  
Swati Agrawal ◽  
Kiran Aggarwal ◽  
Anjali Singh ◽  
Khushbu Saha ◽  
Amrita Mishra ◽  
...  
Keyword(s):  
Rare Case ◽  
Twin Pregnancy ◽  
Gestational Trophoblastic Disease ◽  
Rare Entity ◽  
Trophoblastic Disease ◽  
Complete Mole ◽  
Beta Hcg ◽  
Rare Case Report ◽  
Live Fetus

Twin pregnancy with one live fetus and one complete mole, also known as CMCF i.e. complete molar pregnancy with coexisting live fetus is a rare entity in obstetrics. This combination is associated with increased incidences of spontaneous abortions, vaginal bleeding, prematurity, intrauterine demise, pre-eclampsia, uterine ruptures, theca lutein cysts, persistent gestational trophoblastic disease. We report a rare case of a 24-year-old patient with CMCF at 14 weeks of gestation. After confirming the diagnosis, ruling out malignancy and proper counselling, decision was taken to continue her pregnancy. However, the patient had spontaneous abortion at 15 weeks of gestation. Her serum beta Hcg has shown a decreasing trend in her follow up visits with no signs suggestive of persistent gestational trophoblastic disease.

scholarly journals A Rare Case of Metastatic Choriocarcinoma of Lung Origin

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Parth Rali ◽  
Jianwu Xie ◽  
Grishma Rali ◽  
Mayur Rali ◽  
Jan Silverman ◽  
...  
Keyword(s):  
Rare Case ◽  
Gestational Trophoblastic Disease ◽  
Primary Site ◽  
Reproductive Age ◽  
Gynecologic Malignancy ◽  
Women Of Reproductive Age ◽  
Trophoblastic Disease ◽  
Treatment Prognosis ◽  
Pathological Confirmation

Choriocarcinoma is part of the spectrum of gestational trophoblastic disease that occurs in women of reproductive age. Although the most common metastatic site of choriocarcinoma is the lung, primary pulmonary choriocarcinoma is rare. To diagnose primary pulmonary choriocarcinoma, the patient should have no previous gynecologic malignancy, have elevated human chorionic gonadotropin, and have pathological confirmation of the disease excluding gonadal primary site of the tumor. Due to the paucity of data, there are no guidelines for treatment. Prognosis of this malignancy is extremely poor. We report a rare case of metastatic primary lung choriocarcinoma in a 69-year-old postmenopausal woman who was treated with combination of surgery, chemotherapy, and radiation. The patient had a good outcome and is doing well after 1-year follow-up.

Placental site trophoblastic tumour: the rarest subtype of gestational trophoblastic disease

2020 ◽  
Vol 13 (10) ◽  
pp. e235756
Author(s):  
Mariana M Chaves ◽  
Tiago Maia ◽  
Teresa Margarida Cunha ◽  
Vera Furtado Veiga
Keyword(s):  
Late Onset ◽  
Transvaginal Ultrasound ◽  
Elevated Serum ◽  
Metastatic Potential ◽  
Final Diagnosis ◽  
Gestational Trophoblastic Disease ◽  
Endometrial Biopsy ◽  
Trophoblastic Disease ◽  
Placental Site ◽  
Β Hcg

Placental site trophoblastic tumour (PSTT) is a very rare form of gestational trophoblastic disease that grows slowly, secretes low levels of beta-subunit of human chorionic gonadotropin (β-hCG), presents late-onset metastatic potential and is resistant to several chemotherapy regimens. Here, we report a case of PSTT in a 36-year-old woman who presented with amenorrhea and persistently elevated serum level of β-hCG after a miscarriage. Transvaginal ultrasound revealed a hypovascular ill-defined solid lesion of the uterine fundus and MRI showed a tumour infiltrating the external myometrium with discrete early enhancement and signal restriction on diffusion-weighted imaging. PSTT was suspected, and after endometrial biopsy by hysteroscopy and posterior hysterectomy, microscopic examination allowed the final diagnosis. The level of β-hCG dropped significantly in about a month after surgical treatment. Due to the rarity of PSTT, reporting new cases is crucial to improve the diagnosis and managing of these patients.

scholarly journals Recurrent hydatidiform mole transformed into invasive mole with co-morbid depression- a rare case report

2017 ◽  
Vol 6 (7) ◽  
pp. 3197
Author(s):  
Nisha Bhagat ◽  
Rajnish Raj
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Hydatidiform Mole ◽  
Gestational Trophoblastic Disease ◽  
Placental Site Trophoblastic Tumor ◽  
Trophoblastic Disease ◽  
Placental Site ◽  
Rare Case Report ◽  
Invasive Mole ◽  
Methotrexate Chemotherapy

The gestational trophoblastic disease is a group of interrelated lesions that arise from abnormal proliferation of placental trophoblast. It comprises of hydatidiform mole (partial or complete), invasive mole, placental site trophoblastic tumor and choriocarcinoma. The occurrence of hydatidiform mole in more than two conceptions is known as recurrent hydatidiform mole. Although, its incidence is less than 2% but it may progress to invasive mole or choriocarcinoma. The case of 26-year old female is reported; she had five consecutive molar pregnancies and the sixth one developed into invasive mole with co-morbid depression that was managed by methotrexate chemotherapy, antidepressant and psychotherapy. 

Malignant disease in pregnancy

2010 ◽  
pp. 2181-2185
Author(s):  
Robin A.F. Crawford
Keyword(s):  
Hydatidiform Mole ◽  
Gestational Trophoblastic Disease ◽  
Molar Pregnancy ◽  
Live Births ◽  
Trophoblastic Disease ◽  
Gestational Choriocarcinoma ◽  
Placental Site ◽  
Cancer In Pregnancy ◽  
Malignant Trophoblast ◽  
In Pregnancy

Cancer in pregnancy is rare, affecting less than 1 in 1000 live births. It may be specific to pregnancy (gestational trophoblastic disease) or incidental to it, the less infrequent conditions being melanoma, lymphoma, and cervical malignancy. Gestational trophoblastic disease—a group of conditions that arise in the fetal chorion during various types of pregnancy: histologically they are categorized as (1) partial or complete hydatidiform mole, (2) gestational choriocarcinoma, or (3) placental site trophoblastic tumour. The most common of these conditions is molar pregnancy, when villi are present in association with malignant trophoblast in gestational choriocarcinoma....

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