scholarly journals Metastatic melanoma of the stomach and the duodenum

2006 ◽  
Vol 14 (1-2) ◽  
pp. 60-61 ◽  
Author(s):  
Daniela Benedeto-Stojanov ◽  
Aleksandar Nagorni ◽  
Vesna Zivkovic ◽  
Jovica Milanovic ◽  
Dragan Stojanov
Keyword(s):  
Malignant Melanoma ◽  
Metastatic Melanoma ◽  
Duodenal Bulb ◽  
Gastrointestinal Symptoms ◽  
Endoscopic Biopsy ◽  
Upper Gastrointestinal Endoscopy ◽  
Primary Malignancy ◽  
Melanoma Metastases ◽  
History Of ◽  
One Year

A case of metastatic melanoma of the antrum and duodenal bulb is reported with rare endoscopic findings. A 59-year-old male patient was presented with nausea, vomiting, and abdominal pain one year after excision of malignant melanoma from the back. The tumor was classified as Clark IV, Breslow III. Upper gastrointestinal endoscopy revealed one melanotic polypoid mass with ulcerations at the tip in the antrum and two in the duodenal bulb. Endoscopic biopsy of these polypoid masses showed malignant melanoma metastases. Patients with gastrointestinal symptoms and a history of melanoma should be investigated for the presence of gastrointestinal metastases even if the original primary malignancy was diagnosed years prior to the patient presentation.

scholarly journals Whipple's disease: rare disorder and late diagnosis

2012 ◽  
Vol 54 (5) ◽  
pp. 293-297 ◽  
Author(s):  
Viviane Plasse Renon ◽  
Marcelo Campos Appel-da-Silva ◽  
Rafael Bergesch D'Incao ◽  
Rodrigo Mayer Lul ◽  
Luciana Schmidt Kirschnick ◽  
...  
Keyword(s):  
Gastrointestinal Symptoms ◽  
Disease Diagnosis ◽  
Endoscopic Biopsy ◽  
Upper Gastrointestinal Endoscopy ◽  
Whipple’S Disease ◽  
Whipple's Disease ◽  
Polymerase Chain ◽  
One Year ◽  
Infectious Disorder

Whipple's disease is a rare systemic infectious disorder caused by the bacterium Tropheryma whipplei. We report the case of a 61-year-old male patient who presented to emergency room complaining of asthenia, arthralgia, anorexia, articular complaints intermittent diarrhea, and a 10-kg weight loss in one year. Laboratory tests showed the following results: Hb = 7.5 g/dL, albumin = 2.5 mg/dL, weight = 50.3 kg (BMI 17.4 kg/m²). Upper gastrointestinal endoscopy revealed areas of focal enanthema in the duodenum. An endoscopic biopsy was suggestive of Whipple's disease. Diagnosis was confirmed based on a positive serum polymerase chain reaction. Treatment was initiated with intravenous ceftriaxone followed by oral trimethoprim-sulfamethoxazole. After one year of treatment, the patient was asymptomatic, with Hb = 13.5 g/dL, serum albumin = 5.3 mg/dL, and weight = 70 kg (BMI 24.2 kg/m²). Whipple's disease should be considered a differential diagnosis in patients with prolonged constitutional and/or gastrointestinal symptoms. Appropriate antibiotic treatment improves the quality of life of patients.

scholarly journals Metastatic Melanoma Presenting as Intussusception in an 80-Year-Old Man: A Case Report

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Sarah Alghamdi ◽  
Yumna Omarzai
Keyword(s):  
Differential Diagnosis ◽  
Small Intestine ◽  
Gastrointestinal Tract ◽  
Metastatic Melanoma ◽  
Clinical Presentation ◽  
Gastrointestinal Symptoms ◽  
Common Site ◽  
Neoplastic Process ◽  
History Of ◽  
Uncommon Neoplasm

Malignant melanoma of the gastrointestinal tract is an uncommon neoplasm that could be primary or metastatic. Small intestine represents the most common site for the metastatic melanoma; however, it could be found anywhere in the gastrointestinal tract. Intussusception is a rare cause of intestinal obstruction in adults compared to children. In 90% of the cases, the underlying cause can be found, and in 65% of the cases, intussusception is caused by the neoplastic process. The majority of the neoplasms are benign, and about 15% are malignant. Metastatic melanoma is one of the most common metastatic malignancies to the gastrointestinal tract; however, the premortem diagnosis is rarely made. Here, we report an uncommon clinical presentation of metastatic melanoma causing intussusception in an 80-year-old man. This diagnosis should be considered in a differential diagnosis in any patient who presents with gastrointestinal symptoms and a history of melanoma.

Recurrent primary vulvovaginal malignant melanoma arising in melanoma in situ – the natural history of lesions followed for 23 years

2004 ◽  
Vol 14 (4) ◽  
pp. 628-632
Author(s):  
N. J. Kingston ◽  
R. W. Jones ◽  
J. Baranyai
Keyword(s):  
Malignant Melanoma ◽  
Natural History ◽  
Metastatic Melanoma ◽  
Cutaneous Melanoma ◽  
Mucosal Melanoma ◽  
Histologic Examination ◽  
Melanoma In Situ ◽  
Pigmented Lesions ◽  
History Of

Multifocal melanoma and melanoma in situ of the vulva and vagina are uncommon lesions, and our understanding of their natural history is limited. Vulvovaginal melanoma appears to be biologically different from cutaneous melanoma and has more in common with mucosal melanoma. A 60-year-old woman presented in 1977 with a pigmented vulvar lesion. Histologic examination revealed melanoma in situ associated with focal invasive melanoma. She re-presented with recurrent primary melanomas arising in melanoma in situ in 1990 and 1998 and died of widespread metastatic melanoma in 2000. Melanoma in situ of the vulva and vagina is rare and appears to have a relatively slow but definite progression to invasive melanoma. All suspicious pigmented lesions in this region should be biopsied, and if multifocal in situ melanoma is identified, vulvo(vagin)ectomy should be considered.

Bilateral malignant melanoma metastases to the internal auditory canal/cerebellopontine angle: surgical management and preservation of function

2008 ◽  
Vol 108 (4) ◽  
pp. 803-807 ◽  
Author(s):  
Venelin M. Gerganov ◽  
Nirjhar Hore ◽  
Christian Herold ◽  
Karsten Wrede ◽  
Alexandru C. Stan ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Cerebellopontine Angle ◽  
Systemic Disease ◽  
Internal Auditory Canal ◽  
Prior History ◽  
Caucasian Woman ◽  
Surgical Removal ◽  
Histopathological Analysis ◽  
Melanoma Metastases ◽  
History Of

✓Although intracranial metastases of malignant melanomas are common, localization at the cerebellopontine angle (CPA) or in the internal auditory canal (IAC) is rare, and bilateral presentation especially so. We present the case of a 46-year-old Caucasian woman with bilateral IAC/CPA lesions and a prior history of malignant melanoma on the right leg. During preoperative investigations, the presence of the bilateral IAC/CPA lesions along with several radiologically identified lesions along the neural axis led to the suspicion that she had neurofibromatosis Type 2 despite her history of malignant melanoma and the lack of characteristic skin lesions and family history. Histopathological analysis of the resected lesion confirmed the intraoperative diagnosis of bilateral CPA malignant melanoma metastases. Surgical removal of the tumors via the retrosigmoid approach with preservation of normal bilateral facial nerve function and unilateral serviceable hearing, combined with control of the systemic disease, provided this patient with a near-normal quality of life for at least 42 months after the initial diagnosis of melanoma.

Sonography as a Prognostic Indicator of Breslow Depth: Primary Malignant Melanoma of the Auricular Helix

2021 ◽  
pp. 875647932098102
Author(s):  
Shirly Payano-Griffin
Keyword(s):  
Malignant Melanoma ◽  
Metastatic Melanoma ◽  
Checkpoint Inhibitors ◽  
Treatment Options ◽  
Prognostic Indicator ◽  
Primary Malignancy ◽  
Irregular Border ◽  
Current Therapies ◽  
Melanoma Patients

Malignant melanoma is a cellular cancer that produces pigmentation of the skin. The tendency toward melanoma may be inherited, and risk factors are increased with overexposure to the sun and ultraviolet radiation. Melanomas commonly present as a dark, asymmetrical, mole-like spot that spreads, with an irregular border. It is uncommon to find a melanoma in the auricular regions and even rarer for it to be a primary malignancy of the auricles. Utilizing sonography to evaluate melanoma lesions could serve as a prognostic indicator, regarding Breslow’s depth, an aide in staging, as well as surgical planning. However, utilizing multiple diagnostic imaging modalities is essential in the proper evaluation and staging of a melanoma. Currently there are revolutionary, effective systemic therapies available for patients with a metastatic melanoma. Current therapies are focused on immunotherapy and checkpoint inhibitors. These treatment options provide an opportunity for selected metastatic melanoma patients to achieve healthy long-term success.

scholarly journals A secondary jejunal malignant melanoma from nasal mucosal melanoma: Case report

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110537
Author(s):  
Yingying Xu ◽  
Zongkui Duan ◽  
Wenqing Hu ◽  
Kaixuan Zhu ◽  
Peng Cui ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Past History ◽  
Tumor Therapy ◽  
Gastrointestinal Symptoms ◽  
Primary Melanoma ◽  
Mucosal Melanoma ◽  
The Body ◽  
History Of ◽  
Enhanced Computed Tomography ◽  
Upper Abdomen

Melanomas most commonly localized in the skin can arise anywhere in the body, and approximately 5% of all melanomas appear in other sites of mucosal surfaces out of skin. Primary melanoma from nasal mucosa is quite rare. We present this case: a 46-year-old man had complained a pain in the left upper abdomen for 2 months when he was admitted to the Northern Jiangsu People’s Hospital. The pain was paroxysmal and enhanced when eating. There was no nausea, vomiting, or anorexia. There had been no change in weight in previous months. This patient had a past history of surgery for nasal mucosal malignant melanoma 2 years ago. Abdominal enhanced computed tomography (CT) indicated that a mass originated from small bowel and occupied the left upper abdomen. The patient underwent a laparotomy during which a black lesion measuring about 5 cm × 5 cm × 4 cm was found at the jejunum and resected totally together with partial jejunum. The patient was eventually diagnosed as secondary jejunal malignant melanoma from nasal mucosal melanoma. For patients with a history of melanoma, gastrointestinal metastasis should be considered when patients develop gastrointestinal symptoms. In addition, we recommend positive anti-tumor therapy after surgery.

scholarly journals Case of Metastatic Malignant Melanoma Simulating Granuloma Annulare

2021 ◽  
Vol 5 (3) ◽  
pp. 289-292
Author(s):  
Haley Danielle Heibel ◽  
Parneet Dhaliwal ◽  
Etan Marks ◽  
Clay J. Cockerell
Keyword(s):  
Malignant Melanoma ◽  
Metastatic Melanoma ◽  
Immunohistochemical Staining ◽  
Previous History ◽  
Metastatic Malignant Melanoma ◽  
Granuloma Annulare ◽  
Diagnostic Challenge ◽  
Clinical Presentations ◽  
History Of ◽  
High Index Of Suspicion

Malignant melanoma and particularly metastatic melanoma represent a diagnostic challenge due to the wide variety of histologic patterns, resemblance to benign entities, and extensive range of clinical presentations.  A high index of suspicion for melanoma is important for accurate diagnosis, especially when there is a previous history of malignancy.  Here, we present a patient with a history of melanoma and locally metastatic melanoma, who subsequently developed a nodule on his right forearm near the site of his previous melanoma excision.  Histologically, the melanoma appeared as granuloma annulare (GA) with benign cytologic features, but was identified as metastatic melanoma using SOX-10 immunohistochemical staining.  Other malignancies, including lymphomas, leukemias, sarcomas, and cutaneous metastases of internal malignancies, have mimicked GA and interstitial granulomatous processes.  Therefore, further immunohistochemical staining should be performed to assess for metastatic disease in the setting of a histological pattern that resembles a benign granulomatous process in a patient with a history of malignancy, including malignant melanoma.

Case 17.25

2014 ◽  
pp. 837-838
Author(s):  
Christine U. Lee ◽  
James F. Glockner
Keyword(s):  
Metastatic Melanoma ◽  
Signal Intensity ◽  
Equilibrium Phase ◽  
Gadoxetate Disodium ◽  
Left Hepatic Lobe ◽  
Hepatic Lobe ◽  
Melanoma Metastases ◽  
Phase Images ◽  
History Of

51-year-old man with a history of metastatic melanoma Axial precontrast 3D SPGR images (Figure 17.25.1) reveal multiple T1 hyperintense lesions throughout the liver, representing melanoma metastases. Note also geographic decreased signal intensity in the left hepatic lobe, likely representing fibrotic changes from previous radiotherapy. Many of the lesions are more difficult to visualize on equilibrium phase images obtained 20 minutes after gadoxetate disodium (Eovist) administration (...

scholarly journals Rare cause of massive gastrointestinal bleeding. A case of metastatic melanoma

2019 ◽  
Vol 65 (2) ◽  
Author(s):  
Krzysztof Dąbkowski ◽  
Karolina Michalska ◽  
Natalia Rusiniak-Rossińska ◽  
Andrzej Białek ◽  
Katarzyna Kołaczyk ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Bleeding ◽  
Metastatic Melanoma ◽  
Hypovolemic Shock ◽  
Advanced Melanoma ◽  
Benign Lesions ◽  
Abdominal Symptoms ◽  
Melanoma Metastases ◽  
Massive Gastrointestinal Bleeding ◽  
History Of

The case of a 76-year-old patient, with a history of melanoma, admitted to the department of gastroenterology with symptoms of hypovolemic shock, caused by massive  gastrointestinal bleeding. Clot-covered melanoma metastases were detected in both gastroduodenoscopy and colonoscopy. Gastrointestinal melanoma metastases are found in the majority of patients with advanced melanoma during autopsy; however, they are rarely detected in intravital studies and can be misdiagnosed as other benign lesions in endoscopy. In cases of patients with history of melanoma, metastases should be considered as the cause of non-specific abdominal symptoms, anemia, or bleeding from the gastrointestinal tract.

scholarly journals Black Pleural Effusion: A Unique Presentation of Metastatic Melanoma

2015 ◽  
Vol 8 (2) ◽  
pp. 222-225 ◽  
Author(s):  
Akansha Chhabra ◽  
Vikramjit Mukherjee ◽  
Mudit Chowdhary ◽  
Mauricio Danckers ◽  
David Fridman
Keyword(s):  
Pleural Effusion ◽  
Malignant Melanoma ◽  
Metastatic Melanoma ◽  
Pulmonary Involvement ◽  
The United States ◽  
Radiographic Evaluation ◽  
Pleural Effusions ◽  
Microscopic Appearance ◽  
History Of ◽  
Oxygen Requirements

Metastatic melanoma is a rare form of skin cancer, but one that comes with a high mortality rate. Pulmonary involvement is frequently seen in metastatic melanoma with only 2% of malignant melanoma patients with thorax metastasis presenting with pleural effusions. Herein, we report an extremely rare case of black pleural effusion from thoracic metastasis of cutaneous malignant melanoma. A 74-year-old man with known metastatic melanoma presented with a 1-month history of worsening lower back and hip pain and was found to have extensive osseous metastatic disease and multiple compression fractures. The patient underwent an uneventful kyphoplasty; however, the following day, he became acutely hypoxic and tachypneic with increased oxygen requirements. Radiographic evaluation revealed new bilateral pleural effusions. Bedside thoracentesis revealed a densely exudative, lymphocyte-predominant black effusion. Cytological examination showed numerous neoplastic cells with melanin deposition. A diagnosis of thoracic metastasis of malignant melanoma was established based on the gross and microscopic appearance of the pleural fluid. To the best of our knowledge, this is the first reported case of black pleural effusions secondary to metastatic melanoma in the United States. Despite the rarity of this presentation, it is important to determine the etiology of the black pleural effusion and to keep metastatic melanoma as a differential diagnosis.

Sign in / Sign up

Export Citation Format

Share Document