scholarly journals Influence of tumor size and intestinal wall invasion on development of colorectal liver metastases

2008 ◽  
Vol 55 (4) ◽  
pp. 27-30
Author(s):  
A. Antic ◽  
V. Kalezic ◽  
D. Kecmanovic ◽  
M. Petrovic ◽  
M. Zuvela ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Liver Metastases ◽  
Tumor Size ◽  
Colorectal Liver Metastases ◽  
Subsequent Development ◽  
Lymph Node Involvement ◽  
Intestinal Wall ◽  
Depth Of Invasion ◽  
Clinical Center ◽  
Node Involvement

While the general prognostic factors for colorectal carcinoma have been widely researched, the compound relationships between tumor characteristics and development of colorectal liver metastases have not been clearly understood. The aim of this study was to determine which histopathological characteristics of colorectal cancer may be associated with subsequent development of colorectal liver metastases. We performed retrospective and prospective study which included 80 patients operated for colorectal carcinoma on the First Surgical Clinic of Clinical Center of Serbia in Belgrade. Retrospective group consisted of 40 patients operated between 1992. and 1996. while prospective group included 40 patients treated between 1997. and 2001. We analyzed the size of the tumor, depth of invasion through the intestinal wall, extramural spread of the tumor, infiltration of blood vessels and lymphatics, lymph node involvement, tumor maturation and growth, as well circumferential intestinal involvement. Statistical analysis performed showed highly significant (p<0,01) correlation between the tumor size, degree of maturation of the tumor, extramural spread and involvement of the venules with later development of colorectal liver metastases in both groups.

Significance of hepatic pedicle lymph node involvement in patients with colorectal liver metastases: A prospective study

2002 ◽  
Vol 9 (5) ◽  
pp. 430-438 ◽  
Author(s):  
Daniel Jaeck ◽  
Hiroshi Nakano ◽  
Philippe Bachellier ◽  
Keiichiro Inoue ◽  
Jean-Christophe Weber ◽  
...  
Keyword(s):  
Lymph Node ◽  
Prospective Study ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Lymph Node Involvement ◽  
Hepatic Pedicle ◽  
Node Involvement ◽  
A Prospective Study

Tumor size, depth of invasion, and histologic grade as prognostic factors of lymph node involvement in endometrial cancer: A SEER analysis

2014 ◽  
Vol 133 (2) ◽  
pp. 216-220 ◽  
Author(s):  
Roberto Vargas ◽  
J. Alejandro Rauh-Hain ◽  
Joel Clemmer ◽  
Rachel M. Clark ◽  
Annekathryn Goodman ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Prognostic Factors ◽  
Lymph Node ◽  
Tumor Size ◽  
Lymph Node Involvement ◽  
Histologic Grade ◽  
Depth Of Invasion ◽  
Node Involvement

Significance of lymph node involvement at the hepatic hilum in the resection of colorectal liver metastases

1997 ◽  
Vol 84 (8) ◽  
pp. 1081-1084 ◽  
Author(s):  
K. T. E. Beckurts ◽  
A. H. Hölscher ◽  
St. Thorban ◽  
E. Bollschweiler ◽  
J. R. Siewert
Keyword(s):  
Lymph Node ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Lymph Node Involvement ◽  
Hepatic Hilum ◽  
Node Involvement

Significance of lymph node involvement at the hepatic hilum in the resection of colorectal liver metastases

1997 ◽  
Vol 84 (8) ◽  
pp. 1081-1084 ◽  
Author(s):  
K. T. E. Beckurts ◽  
A. H. Hölscher ◽  
St. Thorban ◽  
E. Bollschweiler ◽  
J. R. Siewert
Keyword(s):  
Lymph Node ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Lymph Node Involvement ◽  
Hepatic Hilum ◽  
Node Involvement

scholarly journals Cyclin D1 expression and its correlation with clinicopathological variables in colorectal carcinoma

2021 ◽  
Vol 11 (1) ◽  
pp. 1868-1872
Author(s):  
Neha Sharma ◽  
Taranveer Singh ◽  
Arshdeep Kaur ◽  
Mridu Manjari ◽  
Shazia Bashir
Keyword(s):  
Lymph Node ◽  
Colorectal Carcinoma ◽  
Cyclin D1 ◽  
Vascular Invasion ◽  
Perineural Invasion ◽  
Lymph Node Involvement ◽  
Depth Of Invasion ◽  
Age Group ◽  
Node Involvement ◽  
Grade Ii

Background: This study was conducted to evaluate the expression of Cyclin D1 in colorectal carcinoma, and to correlate Cyclin D1 positivity with the grade of the tumor along with other parameters such as age, tumor location, lymph node metastasis, and vessel invasion.Materials and Methods: The present cross-sectional study was conducted on 40 proven cases of colorectal carcinoma from October 2015 to October 2017. The tissues were fixed, processed, and stained with hematoxylin and eosin followed by immunohistochemical staining with Cyclin D1 using monoclonal antibodies.Results: 75% of the cases were conventional adenocarcinoma while the rest were mucinous adenocarcinoma. Of the total colorectal carcinomas,12.5% were Grade I, 50% were Grade II and 37.5% cases were Grade III. Cyclin D1 positivity was seen in 60% of cases with the most positivity in grade II tumors. A statistically significant correlation of Cyclin D1 was seen with age group (5th- 6th decade) and histological type of tumor. No significant correlation was seen of Cyclin D1 with lymph node involvement, depth of invasion, vascular invasion, or perineural invasion. A significant statistical correlation was seen with Crohn’s-like reaction and peritumoral lymphocytic response.Conclusions: Thus, it was concluded that a highly statistically significant correlation was seen with age group (5th- 6th decade) and histological type of tumor. No significant correlation was seen with Cyclin D1 expression with lymph node involvement, depth of invasion, vascular invasion, or perineural invasion.

scholarly journals A prospective study to evaluate the impact and independency of depth of invasion in comparison with other clinicopathologic prognostic variables in oral cavity malignancy

2020 ◽  
Vol 6 (2) ◽  
pp. 347
Author(s):  
Subbiah Shanmugam ◽  
Gopu Govindasamy ◽  
X. Gerald Anand Raja
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Cavity ◽  
Staging System ◽  
Lymph Node Involvement ◽  
Stage Migration ◽  
Depth Of Invasion ◽  
Node Metastasis ◽  
Node Involvement ◽  
The Impact

<p class="abstract"><strong>Background:</strong> Depth of invasion is included in the staging of oral cavity malignancies in the recent 8<sup>th</sup> edition of American Joint Committee on Cancer or tumour, node and metastasis staging system. This study analyses the impact of diffuse optical imaging (DOI) on incidence of lymph node involvement, stage migration, postoperative margin and independency.</p><p class="abstract"><strong>Methods:</strong> Postoperative HPE of fifty patients with oral cavity malignancy operated in our institute from January 2018 were collected. Depth of invasion and other pathological parameters were documented. DOI divided into three groups and statistical analysis done.  </p><p class="abstract"><strong>Results:</strong> No lymph node metastasis is found in superficial tumours, 43% of intermediate thickness and 76% of deep tumours had lymph node involvement. Positive margin is seen only in patients with tumour DOI more than 0.5 cm, more than 50% of deep tumours had close margins while 75% of superficial tumours had adequate margin. Out of the 24 T3 tumours in this study 13 were upstaged due to inclusion of DOI, which would have been T2 according to the previous staging system. There is 54.1% (13 out of 24) upstaging in T3 tumours (T2 to T3), 23% (3 out of 13) in T2 (T1 to T2). There is no significant correlation between DOI and anatomical site, tumour size, tumour thickness, lymphovascular invasion and grade.</p><p class="abstract"><strong>Conclusions:</strong> Depth of invasion in oral cavity malignancies impacts adversely lymph node metastasis and margin status. It is an independent prognostic factor in oral cavity malignancy.</p>

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