scholarly journals Natural course of the arteriovenous malformations of the brain

2008 ◽  
Vol 55 (2) ◽  
pp. 107-118 ◽  
Author(s):  
G.M. Tasic ◽  
A. Kostic ◽  
B.M. Djurovic ◽  
V.T. Jovanovic ◽  
I.M. Nikolic ◽  
...  
Keyword(s):  
Clinical Course ◽  
Vascular Malformations ◽  
Total Mortality ◽  
Natural Course ◽  
Clinical Model ◽  
Patient Will ◽  
Cerebral Angioma ◽  
Risk Of Hemorrhage ◽  
The Brain ◽  
Annual Risk

Arteriovenous cerebral malformations represent congenital malformations. Considering the anatomical characteristics of the cerebral angiomas and their localization, in a great number of cases they demand a combined therapeutic approach - surgery,. embolization and radiotherapy. Besides the constant progress of technology, 5% of all cerebral angiomas can not be completely excluded from the circulation. Therefore, the need to understand their natural course became a necessity. Our results point to the fact that they are vascular malformations of a considerably more benign clinical course than the aneurysms. Our clinical model points to an annual risk of hemorrhage which is 3.3% with total mortality of 5.3%, especially if the size of the angioma is 2.5-5 cm, localized in the motor zone of the brain, with combined type of vein drainage and arterial supply from the vertebrobasilary confluence. Epilepsy caused by the cerebral angioma is in 26.7% refractory to medicamentous therapy and in 25% (every 4th patient) will have hemorrhage with an annual risk of 0.14%.

Angiographically cryptic AVM presenting as a pontine tumor

1980 ◽  
Vol 53 (6) ◽  
pp. 846-848 ◽  
Author(s):  
A. Leland Albright ◽  
Ryland P. Byrd ◽  
Mary Lee Harrison
Keyword(s):  
Arteriovenous Malformation ◽  
Brain Stem ◽  
Clinical Course ◽  
Vascular Malformations ◽  
Content Type ◽  
Booster Injection ◽  
The Brain ◽  
Fine Print

✓ A 19-month-old child became disoriented and ataxic 6 days after a diphtheria-pertussis-tetanus (DPT) booster injection. Computerized tomographic scan revealed a hyperdense mesencephalic-pontine mass, and angiography demonstrated an avascular mass. Pontine biopsy revealed no abnormality. Her clinical course fluctuated until her death 15 months later. At autopsy, an angiographically cryptic arteriovenous malformation (AVM) was present in the mesencephalon and pons. Vascular malformations of the brain stem, producing prolonged clinical courses, are reviewed.

scholarly journals Involvement of Microglia in the Pathophysiology of Intracranial Aneurysms and Vascular Malformations—A Short Overview

2021 ◽  
Vol 22 (11) ◽  
pp. 6141
Author(s):  
Teodora Larisa Timis ◽  
Ioan Alexandru Florian ◽  
Sergiu Susman ◽  
Ioan Stefan Florian
Keyword(s):  
Immune Cells ◽  
Arteriovenous Malformations ◽  
Intracranial Aneurysms ◽  
Immune Cell ◽  
Vascular Malformations ◽  
Cerebral Injury ◽  
Future Research ◽  
Mortality And Morbidity ◽  
The Central Nervous System ◽  
The Brain

Aneurysms and vascular malformations of the brain represent an important source of intracranial hemorrhage and subsequent mortality and morbidity. We are only beginning to discern the involvement of microglia, the resident immune cell of the central nervous system, in these pathologies and their outcomes. Recent evidence suggests that activated proinflammatory microglia are implicated in the expansion of brain injury following subarachnoid hemorrhage (SAH) in both the acute and chronic phases, being also a main actor in vasospasm, considerably the most severe complication of SAH. On the other hand, anti-inflammatory microglia may be involved in the resolution of cerebral injury and hemorrhage. These immune cells have also been observed in high numbers in brain arteriovenous malformations (bAVM) and cerebral cavernomas (CCM), although their roles in these lesions are currently incompletely ascertained. The following review aims to shed a light on the most significant findings related to microglia and their roles in intracranial aneurysms and vascular malformations, as well as possibly establish the course for future research.

Natural course of HCV viremia following liver transplantation and clinical course of reinfection

1997 ◽  
Vol 29 (6) ◽  
pp. 2635-2639
Author(s):  
R. Safadi ◽  
D. Shouval ◽  
Y. Ashur ◽  
A. Eid ◽  
O. Jurim ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Clinical Course ◽  
Natural Course

scholarly journals Natural course of typical and atypical parenchymal solitary cysticercus granuloma of the brain: a 3-year prospective clinico-radiological study

2015 ◽  
Vol 29 (1) ◽  
pp. 19-29 ◽  
Author(s):  
Neeraj Kumar ◽  
Ravindra Kumar Garg ◽  
Hardeep Singh Malhotra ◽  
Rakesh Kumar Gupta ◽  
Rajesh Verma ◽  
...  
Keyword(s):  
Natural Course ◽  
Radiological Study ◽  
The Brain

scholarly journals Molecular biology of vascular malformations of the brain

2001 ◽  
Vol 10 (4) ◽  
pp. 271
Author(s):  
Issam A. Awad ◽  
M Sc ◽  
FACS ◽  
MA(Hon)
Keyword(s):  
Molecular Biology ◽  
Vascular Malformations ◽  
The Brain

scholarly journals Intravascular lymphomatosis of central nervious system - case report

2003 ◽  
Vol 131 (7-8) ◽  
pp. 325-328 ◽  
Author(s):  
Jasmina Jovic ◽  
Marko Ercegovac ◽  
Branko Dozic ◽  
Dubravka Cvetkovic ◽  
Miroslava Zivkovic ◽  
...  
Keyword(s):  
Clinical Course ◽  
Vascular Occlusion ◽  
Epileptic Seizures ◽  
Signs And Symptoms ◽  
Lymphoid Cells ◽  
Cognitive Changes ◽  
Small Vessels ◽  
Intravascular Lymphomatosis ◽  
Systemic Manifestations ◽  
The Brain

Intravascular lymphomatosis is an uncommon lymphoproliferative disorder characterised by intravascular distribution of neoplastic lymphoid cells (B- or T- lymphocites), what leads to occlusion of small vessels and causes signs and simptoms of disorder. Its initial predilection sites are the brain or the skin, and hematopoetic organs are usually spared. The signs and symptoms of the disorder are attributed to vascular occlusion. Clinical course is fatal, besides therapy. In our case disorder has started with partial epileptic seizures with secondary generalisation, and after that with motor aphasia, right hemi paresis, urinary incontinence and cognitive changes. She was hospitalized for several times, completely investigated, but with no conclusion. Seven months after appearance of symptoms, she died. And diagnosis was determined at autopsy. A myriad of neurological and systemic manifestations are putting us in an unequal position with this fatal disease. Early diagnosis can increase survival and decrease intensity of symptoms. So every new case is important as warning that we must not forget about this disease.

scholarly journals PECULIARITIES OF THE CLINICAL COURSE OF POSTMEASLES ENCEPHALITIS IN IMMUNOSUPRESSED PEOPLE

2021 ◽  
Vol 64 (1) ◽  
Author(s):  
Tetiana Nehrych ◽  
◽  
Maria Shorobura ◽  
Irina Hritsyna ◽  
Liliia Yukhimiv ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Monoclonal Antibodies ◽  
Inclusion Body ◽  
Bacterial Pneumonia ◽  
Clinical Course ◽  
Risk Group ◽  
Neurological Complications ◽  
Immunosuppressive Drugs ◽  
The Central Nervous System ◽  
The Brain

Primary acute measles encephalitis and acute postmeasles encephalitis are the most common neurological complications of measles. It is important to detect encephalitis, which develops a month or more after the manifestations of measles infection. These encephalitis are rare and occur mainly in people with immunodefi ciency. Multiple sclerosis is a chronic disease of the central nervous system for the treatment of which diseasemodifying therapy is used, namely monoclonal antibodies, that can lead to immunosuppression and immunodefi ciency. Nowadays, there is insuffi cient information about the course of postcortical encephalitis in patients with multiple sclerosis who are taking immunosuppressive drugs. The article presents data on the clinical classifi cation, diagnosis and treatment of measles encephalitis. A clinical case of measles inclusion body encephalitis in a thirty-threeyear-old patient with multiple sclerosis on the background of annual intake of monoclonal antibodies is presented. She also had viral-bacterial pneumonia and developed disseminated intravascular coagulation in the brain and lungs. These complications of measles infection led to the death of the person after a month and a half of intensive care. Thus, patients with multiple sclerosis who are taking drugs with immunosuppressive eff ects are among the risk group for measles inclusion body encephalitis. Measles inclusion body encephalitis in such patients can be severe, which complicates timely diagnosis, proper treatment and leads to death.

Dr. Feig Replies

PEDIATRICS ◽  
1977 ◽  
Vol 59 (1) ◽  
pp. 145-145
Author(s):  
Stephen A. Feig
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Radiation Therapy ◽  
Brain Stem ◽  
Metastatic Disease ◽  
Clinical Course ◽  
Convincing Evidence ◽  
Additional Radiation ◽  
The Brain ◽  
Bony Erosion

Thank you for the opportunity to reply to the letter of Drs. McWilliams and Maurer. We were truly perplexed by the presentation of the meningeal metastases in the reported patient. Lacking convincing evidence of central nervous system metastatic disease or bony erosion of the skull, we were loath to apply chemotherapy, which might have aggravated his clinical course and would have been of doubtful efficacy in any event. Additional radiation therapy was felt to be inadvisable because, in the opinion of our radiotherapists, the patient had been treated originally with a dose that closely approached the tolerance of the brain stem.

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