scholarly journals Doppler hemodynamic study in evaluation of liver metastases

2007 ◽  
Vol 54 (2) ◽  
pp. 9-12 ◽  
Author(s):  
S. Stojcic-Djenic ◽  
R. Sarenac-Kovac ◽  
M. Kerkez ◽  
V. Jurisic
Keyword(s):  
Colon Cancer ◽  
Liver Metastasis ◽  
Early Detection ◽  
Liver Metastases ◽  
Color Doppler ◽  
Duplex Ultrasound ◽  
Liver Circulation ◽  
Non Invasive ◽  
Invasive Method ◽  
Hemodynamic Study

The color Doppler spectral analyses can be usefully in description of the liver circulation as one from non-invasive methods. Using color Doppler B mod ultrasound (Toshiba Core Vision) with duplex ultrasound we founded difference in liver circulation between patients with colon cancer and liver metastasis in comparison with those without metastases. We suggested this non invasive method for early detection of occult liver metastasis presence. .

scholarly journals Early detection with renal Doppler resistive index measurements of hemorrhagic shock in polytrauma patients

2017 ◽  
Vol 4 (2) ◽  
pp. 420
Author(s):  
Nitishkumar Dhanajirao Yeslawath
Keyword(s):  
Early Detection ◽  
Hemorrhagic Shock ◽  
Injury Severity ◽  
Resistive Index ◽  
Shock Group ◽  
Radiology Department ◽  
Non Invasive ◽  
Invasive Method ◽  
A Prospective Study ◽  
Renal Doppler

Background: Poly trauma is a major cause of morbidity and mortality in both developed and developing countries. The aim was to investigate whether renal Doppler RI changes occur early with posttraumatic bleeding and whether the renal Doppler RI may enable accurate prediction of occult hypoperfusion and thus be predictive of the development of hemorrhagic shock in polytrauma patients.Methods: It was a prospective study involving patients admitted in the causality and evaluated by radiology department. Study was done in a period of 6 months from June 2016-December 2016.  Renal Doppler RI was measured in 48 hemodynamically stable adult patients admitted in emergency because of polytrauma.Results: 26 patients developed hemorrhagic shock, and 22 did not. Hemorrhagic shock group, as compared with the nonhemorrhagic shock group, had higher renal Doppler RI (mean, 0.79±0.11 [standard deviation] vs 0.61±0.2; P<0.01), injury severity score (mean, 33±12 vs 25±9; P<0.01), and standard base excess (mean, -4.0mEq/L±4 vs 1mEq/L±3; P≤0.05) values. At logistic regression analysis, a renal Doppler RI greater than 0.9 was the only independent risk factor for progression to hemorrhagic shock (P<0.001).Conclusions: Renal Doppler RI measurement may represent a clinically useful non-invasive method for the early detection of occult hemorrhagic shock.

scholarly journals An Early Detection of Acute Compartment Syndrome in Fastened Zip-Tie Rat Model Using Dynamic Phosphorous-31 Magnetic Resonance Spectroscopy at 9.4 Tesla

2021 ◽  
Author(s):  
Hiroki Ohta ◽  
Nhat-Minh Van Vo ◽  
Junichi Hata ◽  
Koshiro Terawaki ◽  
Takako Shirakawa ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Early Detection ◽  
Magnetic Resonance Spectroscopy ◽  
Compartment Syndrome ◽  
Rat Model ◽  
Resonance Spectroscopy ◽  
Non Invasive ◽  
Arterial Ph ◽  
Invasive Method ◽  
Muscular Damage

Abstract IntroductionAcute compartment syndrome (ACS) leads to a series of health problems, limb salvage, disability, and even death. In vivo phosphorus-31 magnetic resonance spectroscopy (31P-MRS) provides a unique non-invasive method to assess skeletal muscle metabolisms such as inorganic phosphate (Pi), phosphocreatine (PCr), and adenosine triphosphate (ATP). The study aims to assess the ability of dynamic 31P-MRS in the early detection of muscular damage in ACS.Materials & MethodsThe study induced the fastened zip-tie model of ACS on normotensive Sprague-Dawley rats (n = 6). The spectra were acquired in Bruker 9.4-Tesla preclinical scanner using 1H/31P surface coil. 31P-MRS spectra and blood samples were obtained at time 0 (pre-ischemic phase) and every 15 minutes during the compression (120 minutes) and the reperfusion phase (90 minutes). 31P-MRS spectra findings were compared with plasma creatine phosphokinase (CPK).ResultsPCr/(Pi + PCr) ratio significantly decreased after muscle was compressed (P < 0.05). In contrast to this, CPK did not change significantly (P > 0.05). Both intracellular pH and arterial pH decreased over time. However, intracellular declined significantly (P < 0.05) at 60 minutes of ischemic state, and at 5 minutes and 60 minutes of reperfusion, while arterial pH slightly changed. After 30 minutes of ischemic, phosphomonoesters (PME) peak was detected, which was not seen at the pre-ischemic phase. It gradually increased and reached its highest peak at 120 minutes. At reperfusion state, 31P-MRS spectra and pH did not fully recover to their pre-ischemic state, and PME peak disappeared. There was a correlation between T2-weighted images and CPK from blood tests (R2 = 0.1996, P < 0.05).ConclusionsDynamic 31P-MRS technique is more clearly and rapidly detect the bioenergetic and mitochondrial functions change than blood test in a fastened zip-tie rat model of ACS. This technique is a promising non-invasive method to detect the early ischemic muscular damage in ACS.

Does primary site of colorectal cancer become a prognostic factor of patients undergoing curative resection of liver metastases?

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 772-772 ◽  
Author(s):  
Rika Kizawa ◽  
Yasushi Ichikawa ◽  
Fumitaka Kumamoto ◽  
Yu Sawada ◽  
Ryusei Matsuyama ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Colon Cancer ◽  
Liver Metastasis ◽  
Prognostic Factor ◽  
Liver Metastases ◽  
Curative Resection ◽  
Cox Regression ◽  
Univariate Analysis ◽  
Primary Site ◽  
Significant Difference

772 Background: The comparison of prognosis between right and left-sided colon cancer (RC, LC) has recently attracted a lot of attention. We examined whether primary location of colo-rectal cancer represents a prognostic factor of patients received curative resection of liver metastasis. Methods: We reviewed all patients undergoing resection of liver metastasis of colo-rectal cancer from1992 to 2013 in the 2 YCU hospitals, and selected eligible 377 patients (59 [15.6 %] with RC, 318 [84.4 %] with LC) undergoing R0 or 1 resection of primary and metastatic lesions. Patients with transverse colon cancer were excluded. We stratified patients according to previously-reported prognostic factors of hepatic metastasis resection, and conducted univariate analysis by Log Rank test to compared overall survival (OS) in each stratum. Using those results, independent factors affecting OS were determined by multivariable Cox regression. Results: The median OS of 377 patients was 66 months, and disease free survival (DFS) was 11.6 months. Univariate analysis revealed that the number and maximum diameter of liver metastasis, existence of other metastasis apart from liver, CEA, and having pre- or post- operative chemotherapy showed significant difference of OS. Primary site did not show significant difference of OS (p = 0.547), but median OS of LC (67 months) was 24 months longer than of RC. As for DFS, there was no significant difference between RC and LC (10.75 vs. 11.6 months, p = 0.873). Multivariate Cox regression analysis was conducted using former factors showing significant difference and primary site. Then primary site was an independent prognostic factor (p = 0.047). LC showed a lower risk than RC (HR: 0.675). Conclusions: The primary site did not affect DFS, but could become a prognostic factor of OS with patients undergoing curative resection of liver metastases. It suggested that curative resection of liver metastases could contribute to prolong survival, regardless of RC or LC. And there is some possibility that the primary site affects prognosis after post-operative recurrence of colo-rectal cancer liver metastases.

scholarly journals Validation of a non-invasive method for the early detection of metabolic syndrome: a diagnostic accuracy test in a working population

BMJ Open ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. e020476 ◽  
Author(s):  
Manuel Romero-Saldaña ◽  
Pedro Tauler ◽  
Manuel Vaquero-Abellán ◽  
Angel-Arturo López-González ◽  
Francisco-José Fuentes-Jiménez ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Early Detection ◽  
Diagnostic Test ◽  
Youden Index ◽  
Test Accuracy ◽  
Age Group ◽  
Validity Index ◽  
Interaction Detection ◽  
Non Invasive ◽  
Invasive Method

ObjectivesA non-invasive method for the early detection of metabolic syndrome (NIM-MetS) using only waist-to-height ratio (WHtR) and blood pressure (BP) has recently been published, with fixed cut-off values for gender and age. The aim of this study was to validate this method in a large sample of Spanish workers.DesignA diagnostic test accuracy to assess the validity of the method was performed.SettingOccupational health services.ParticipantsThe studies were conducted in 2012–2016 on a sample of 60 799 workers from the Balearic Islands (Spain).InterventionsThe NCEP-ATP III criteria were used as the gold standard. NIM-MetS has been devised using classification trees (the χ2automatic interaction detection method).Main outcome measuresAnthropometric and biochemical variables to diagnose MetS. Sensitivity, specificity, validity index and Youden Index were determined to analyse the accuracy of the diagnostic test (NIM-MetS).ResultsWith regard to the validation of the method, sensitivity was 54.7%, specificity 94.9% and the Validity Index 91.2%. The cut-off value for WHtR was 0.54, ranging from 0.51 (lower age group) to 0.56 (higher age group). Variables more closely associated with MetS were WHtR (area under the curve (AUC)=0.85; 95% CI 0.84 to 0.86) and systolic BP (AUC=0.79; 95% CI 0.78 to 0.80)). The final cut-off values for the non-invasive method were WHtR ≥0.56 and BP ≥128/80 mm Hg, which includes four levels of MetS risk (very low, low, moderate and high).ConclusionsThe analysed method has shown a high validity index (higher than 91%) for the early detection of MetS. It is a non-invasive method that is easy to apply and interpret in any healthcare setting. This method provides a scale of MetS risk which allows more accurate detection and more effective intervention.

scholarly journals Towards a non-invasive method for early detection of testicular neoplasia in semen samples by identification of fetal germ cell-specific markers

2006 ◽  
Vol 22 (1) ◽  
pp. 167-173 ◽  
Author(s):  
C.E. Hoei-Hansen ◽  
E. Carlsen ◽  
N. Jorgensen ◽  
H. Leffers ◽  
N.E. Skakkebaek ◽  
...  
Keyword(s):  
Early Detection ◽  
Germ Cell ◽  
Non Invasive ◽  
Invasive Method ◽  
Fetal Germ Cell

scholarly journals Radiomics and Radiogenomics in Evaluation of Colorectal Cancer Liver Metastasis

2022 ◽  
Vol 11 ◽  
Author(s):  
Yun Wang ◽  
Lu-Yao Ma ◽  
Xiao-Ping Yin ◽  
Bu-Lang Gao
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Liver Metastases ◽  
Texture Features ◽  
Biological Properties ◽  
Imaging Features ◽  
Current Application ◽  
Colorectal Cancer Liver Metastases ◽  
Colorectal Cancer Liver Metastasis ◽  
Non Invasive

Colorectal cancer is one common digestive malignancy, and the most common approach of blood metastasis of colorectal cancer is through the portal vein system to the liver. Early detection and treatment of liver metastasis is the key to improving the prognosis of the patients. Radiomics and radiogenomics use non-invasive methods to evaluate the biological properties of tumors by deeply mining the texture features of images and quantifying the heterogeneity of metastatic tumors. Radiomics and radiogenomics have been applied widely in the detection, treatment, and prognostic evaluation of colorectal cancer liver metastases. Based on the imaging features of the liver, this paper reviews the current application of radiomics and radiogenomics in the diagnosis, treatment, monitor of disease progression, and prognosis of patients with colorectal cancer liver metastases.

New non-invasive method for early detection of metabolic syndrome in the working population

2016 ◽  
Vol 15 (7) ◽  
pp. 549-558 ◽  
Author(s):  
Manuel Romero-Saldaña ◽  
Francisco J Fuentes-Jiménez ◽  
Manuel Vaquero-Abellán ◽  
Carlos Álvarez-Fernández ◽  
Guillermo Molina-Recio ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Early Detection ◽  
Working Population ◽  
Non Invasive ◽  
Invasive Method
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