scholarly journals Towards a non-invasive method for early detection of testicular neoplasia in semen samples by identification of fetal germ cell-specific markers

2006 ◽  
Vol 22 (1) ◽  
pp. 167-173 ◽  
Author(s):  
C.E. Hoei-Hansen ◽  
E. Carlsen ◽  
N. Jorgensen ◽  
H. Leffers ◽  
N.E. Skakkebaek ◽  
...  
Keyword(s):  
Early Detection ◽  
Germ Cell ◽  
Non Invasive ◽  
Invasive Method ◽  
Fetal Germ Cell

scholarly journals Early detection with renal Doppler resistive index measurements of hemorrhagic shock in polytrauma patients

2017 ◽  
Vol 4 (2) ◽  
pp. 420
Author(s):  
Nitishkumar Dhanajirao Yeslawath
Keyword(s):  
Early Detection ◽  
Hemorrhagic Shock ◽  
Injury Severity ◽  
Resistive Index ◽  
Shock Group ◽  
Radiology Department ◽  
Non Invasive ◽  
Invasive Method ◽  
A Prospective Study ◽  
Renal Doppler

Background: Poly trauma is a major cause of morbidity and mortality in both developed and developing countries. The aim was to investigate whether renal Doppler RI changes occur early with posttraumatic bleeding and whether the renal Doppler RI may enable accurate prediction of occult hypoperfusion and thus be predictive of the development of hemorrhagic shock in polytrauma patients.Methods: It was a prospective study involving patients admitted in the causality and evaluated by radiology department. Study was done in a period of 6 months from June 2016-December 2016.  Renal Doppler RI was measured in 48 hemodynamically stable adult patients admitted in emergency because of polytrauma.Results: 26 patients developed hemorrhagic shock, and 22 did not. Hemorrhagic shock group, as compared with the nonhemorrhagic shock group, had higher renal Doppler RI (mean, 0.79±0.11 [standard deviation] vs 0.61±0.2; P<0.01), injury severity score (mean, 33±12 vs 25±9; P<0.01), and standard base excess (mean, -4.0mEq/L±4 vs 1mEq/L±3; P≤0.05) values. At logistic regression analysis, a renal Doppler RI greater than 0.9 was the only independent risk factor for progression to hemorrhagic shock (P<0.001).Conclusions: Renal Doppler RI measurement may represent a clinically useful non-invasive method for the early detection of occult hemorrhagic shock.

scholarly journals An Early Detection of Acute Compartment Syndrome in Fastened Zip-Tie Rat Model Using Dynamic Phosphorous-31 Magnetic Resonance Spectroscopy at 9.4 Tesla

2021 ◽  
Author(s):  
Hiroki Ohta ◽  
Nhat-Minh Van Vo ◽  
Junichi Hata ◽  
Koshiro Terawaki ◽  
Takako Shirakawa ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Early Detection ◽  
Magnetic Resonance Spectroscopy ◽  
Compartment Syndrome ◽  
Rat Model ◽  
Resonance Spectroscopy ◽  
Non Invasive ◽  
Arterial Ph ◽  
Invasive Method ◽  
Muscular Damage

Abstract IntroductionAcute compartment syndrome (ACS) leads to a series of health problems, limb salvage, disability, and even death. In vivo phosphorus-31 magnetic resonance spectroscopy (31P-MRS) provides a unique non-invasive method to assess skeletal muscle metabolisms such as inorganic phosphate (Pi), phosphocreatine (PCr), and adenosine triphosphate (ATP). The study aims to assess the ability of dynamic 31P-MRS in the early detection of muscular damage in ACS.Materials & MethodsThe study induced the fastened zip-tie model of ACS on normotensive Sprague-Dawley rats (n = 6). The spectra were acquired in Bruker 9.4-Tesla preclinical scanner using 1H/31P surface coil. 31P-MRS spectra and blood samples were obtained at time 0 (pre-ischemic phase) and every 15 minutes during the compression (120 minutes) and the reperfusion phase (90 minutes). 31P-MRS spectra findings were compared with plasma creatine phosphokinase (CPK).ResultsPCr/(Pi + PCr) ratio significantly decreased after muscle was compressed (P < 0.05). In contrast to this, CPK did not change significantly (P > 0.05). Both intracellular pH and arterial pH decreased over time. However, intracellular declined significantly (P < 0.05) at 60 minutes of ischemic state, and at 5 minutes and 60 minutes of reperfusion, while arterial pH slightly changed. After 30 minutes of ischemic, phosphomonoesters (PME) peak was detected, which was not seen at the pre-ischemic phase. It gradually increased and reached its highest peak at 120 minutes. At reperfusion state, 31P-MRS spectra and pH did not fully recover to their pre-ischemic state, and PME peak disappeared. There was a correlation between T2-weighted images and CPK from blood tests (R2 = 0.1996, P < 0.05).ConclusionsDynamic 31P-MRS technique is more clearly and rapidly detect the bioenergetic and mitochondrial functions change than blood test in a fastened zip-tie rat model of ACS. This technique is a promising non-invasive method to detect the early ischemic muscular damage in ACS.

scholarly journals Validation of a non-invasive method for the early detection of metabolic syndrome: a diagnostic accuracy test in a working population

BMJ Open ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. e020476 ◽  
Author(s):  
Manuel Romero-Saldaña ◽  
Pedro Tauler ◽  
Manuel Vaquero-Abellán ◽  
Angel-Arturo López-González ◽  
Francisco-José Fuentes-Jiménez ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Early Detection ◽  
Diagnostic Test ◽  
Youden Index ◽  
Test Accuracy ◽  
Age Group ◽  
Validity Index ◽  
Interaction Detection ◽  
Non Invasive ◽  
Invasive Method

ObjectivesA non-invasive method for the early detection of metabolic syndrome (NIM-MetS) using only waist-to-height ratio (WHtR) and blood pressure (BP) has recently been published, with fixed cut-off values for gender and age. The aim of this study was to validate this method in a large sample of Spanish workers.DesignA diagnostic test accuracy to assess the validity of the method was performed.SettingOccupational health services.ParticipantsThe studies were conducted in 2012–2016 on a sample of 60 799 workers from the Balearic Islands (Spain).InterventionsThe NCEP-ATP III criteria were used as the gold standard. NIM-MetS has been devised using classification trees (the χ2automatic interaction detection method).Main outcome measuresAnthropometric and biochemical variables to diagnose MetS. Sensitivity, specificity, validity index and Youden Index were determined to analyse the accuracy of the diagnostic test (NIM-MetS).ResultsWith regard to the validation of the method, sensitivity was 54.7%, specificity 94.9% and the Validity Index 91.2%. The cut-off value for WHtR was 0.54, ranging from 0.51 (lower age group) to 0.56 (higher age group). Variables more closely associated with MetS were WHtR (area under the curve (AUC)=0.85; 95% CI 0.84 to 0.86) and systolic BP (AUC=0.79; 95% CI 0.78 to 0.80)). The final cut-off values for the non-invasive method were WHtR ≥0.56 and BP ≥128/80 mm Hg, which includes four levels of MetS risk (very low, low, moderate and high).ConclusionsThe analysed method has shown a high validity index (higher than 91%) for the early detection of MetS. It is a non-invasive method that is easy to apply and interpret in any healthcare setting. This method provides a scale of MetS risk which allows more accurate detection and more effective intervention.

New non-invasive method for early detection of metabolic syndrome in the working population

2016 ◽  
Vol 15 (7) ◽  
pp. 549-558 ◽  
Author(s):  
Manuel Romero-Saldaña ◽  
Francisco J Fuentes-Jiménez ◽  
Manuel Vaquero-Abellán ◽  
Carlos Álvarez-Fernández ◽  
Guillermo Molina-Recio ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Early Detection ◽  
Working Population ◽  
Non Invasive ◽  
Invasive Method

scholarly journals Doppler hemodynamic study in evaluation of liver metastases

2007 ◽  
Vol 54 (2) ◽  
pp. 9-12 ◽  
Author(s):  
S. Stojcic-Djenic ◽  
R. Sarenac-Kovac ◽  
M. Kerkez ◽  
V. Jurisic
Keyword(s):  
Colon Cancer ◽  
Liver Metastasis ◽  
Early Detection ◽  
Liver Metastases ◽  
Color Doppler ◽  
Duplex Ultrasound ◽  
Liver Circulation ◽  
Non Invasive ◽  
Invasive Method ◽  
Hemodynamic Study

The color Doppler spectral analyses can be usefully in description of the liver circulation as one from non-invasive methods. Using color Doppler B mod ultrasound (Toshiba Core Vision) with duplex ultrasound we founded difference in liver circulation between patients with colon cancer and liver metastasis in comparison with those without metastases. We suggested this non invasive method for early detection of occult liver metastasis presence. .

Malfunctional Reorganization in the Developing Limbo-Prefrontal System in Animals: Implications for Human Psychoses?

2001 ◽  
Vol 12 (1) ◽  
pp. 8-14
Author(s):  
Gertraud Teuchert-Noodt ◽  
Ralf R. Dawirs
Keyword(s):  
Prefrontal Cortex ◽  
Mental Disorders ◽  
Dentate Gyrus ◽  
Cognitive Functions ◽  
Experimental Approach ◽  
Regulatory Mechanisms ◽  
Hippocampal Dentate Gyrus ◽  
Non Invasive ◽  
Invasive Method ◽  
Activity Dependent

Abstract: Neuroplasticity research in connection with mental disorders has recently bridged the gap between basic neurobiology and applied neuropsychology. A non-invasive method in the gerbil (Meriones unguiculus) - the restricted versus enriched breading and the systemically applied single methamphetamine dose - offers an experimental approach to investigate psychoses. Acts of intervening affirm an activity dependent malfunctional reorganization in the prefrontal cortex and in the hippocampal dentate gyrus and reveal the dopamine position as being critical for the disruption of interactions between the areas concerned. From the extent of plasticity effects the probability and risk of psycho-cognitive development may be derived. Advance may be expected from insights into regulatory mechanisms of neurogenesis in the hippocampal dentate gyrus which is obviously to meet the necessary requirements to promote psycho-cognitive functions/malfunctions via the limbo-prefrontal circuit.

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