scholarly journals Inhibition of the hepatic glucose output is responsible for the hypoglycemic effect of Crataegus aronia against type 2 diabetes mellitus in rats

2018 ◽  
Vol 70 (2) ◽  
pp. 277-287 ◽  
Author(s):  
Dalia Mostafa ◽  
Eman Khaleel ◽  
Ghada Abdel-Aleem
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Hypoglycemic Effect ◽  
Hepatic Glucose Output ◽  
Hepatic Glucose ◽  
Glucose Output

scholarly journals The Relationship between Type 2 Diabetes Mellitus and Related Thyroid Diseases

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Chaoxun Wang
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Thyroid Dysfunction ◽  
Enhanced Absorption ◽  
Hepatic Glucose ◽  
Glucose Output

Type 2 diabetes mellitus (T2DM) has an intersecting underlying pathology with thyroid dysfunction. The literature is punctuated with evidence indicating a contribution of abnormalities of thyroid hormones to type 2 DM. The most probable mechanism leading to T2DM in thyroid dysfunction could be attributed to perturbed genetic expression of a constellation of genes along with physiological aberrations leading to impaired glucose utilization and disposal in muscles, overproduction of hepatic glucose output, and enhanced absorption of splanchnic glucose. These factors contribute to insulin resistance. Insulin resistance is also associated with thyroid dysfunction. Hyper- and hypothyroidism have been associated with insulin resistance which has been reported to be the major cause of impaired glucose metabolism in T2DM. The state-of-art evidence suggests a pivotal role of insulin resistance in underlining the relation between T2DM and thyroid dysfunction. A plethora of preclinical, molecular, and clinical studies have evidenced an undeniable role of thyroid malfunctioning as a comorbid disorder of T2DM. It has been investigated that specifically designed thyroid hormone analogues can be looked upon as the potential therapeutic strategies to alleviate diabetes, obesity, and atherosclerosis. These molecules are in final stages of preclinical and clinical evaluation and may pave the way to unveil a distinct class of drugs to treat metabolic disorders.

scholarly journals Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus.

1998 ◽  
Vol 102 (3) ◽  
pp. 619-624 ◽  
Author(s):  
C Meyer ◽  
M Stumvoll ◽  
V Nadkarni ◽  
J Dostou ◽  
A Mitrakou ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glucose Metabolism ◽  
Hepatic Glucose Metabolism ◽  
Hepatic Glucose

scholarly journals Hepatic Glucose Output Inhibition by Mexican Plants Used in the Treatment of Type 2 Diabetes

2020 ◽  
Vol 11 ◽  
Author(s):  
Gerardo Mata-Torres ◽  
Adolfo Andrade-Cetto ◽  
Fernanda Artemisa Espinoza-Hernández ◽  
René Cárdenas-Vázquez
Keyword(s):  
Type 2 Diabetes ◽  
Hepatic Glucose Output ◽  
Hepatic Glucose ◽  
Glucose Output

PHARMACOEPIDEMIOLOGICAL STUDY OF THE EFFECTIVENESS OF HYPERGLYCEMIA CORRECTION AMONG PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH LIVER LESIONS WITH DIABETES LOWERING THERAPY AND ESSENTIAL PHOSPHOLIPID DRUGS

2020 ◽  
pp. 28-40
Author(s):  
Valery B. Maksimenko ◽  
Luka A. Gromakov ◽  
Svetlana E. Sinyutina
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Type 2 Diabetes Mellitus ◽  
Relative Risk ◽  
Fold Increase ◽  
Hypoglycemic Effect ◽  
Liver Lesions ◽  
Essential Phospholipids

The aim of the study is to study the possibility of improving the effectiveness of hyperglycemia treatment among patients with type 2 diabetes mellitus by correcting the structural-functional state of the liver using essential phospholipid preparations. Materials and methods. The cohort retrospective study examined the medical histories of 1050 patients with type 2 diabetes mellitus, among whom 205 had liver complications. Diagnosis of steatohepatitis among patients with type 2 diabetes mellitus was verified based on increased activity of hepatic transaminases and serum bilirubin concentration. Metabolic syndrome was verified according to 3 criteria: abdominal obesity, dyslipidemia and arterial hypertension. Fatty hepatosis was diagnosed based on an ultrasound study. Three times during the course of treatment of the patients the glycemic profile was studied. Patients were divided into study groups: type 2 diabetes mellitus without liver diseases (control); type 2 diabetes mellitus with liver disease (chronic persistent hepatitis, chronic steatohepatitis) received standard diabetes reduction therapy; type 2 diabetes mellitus with the same liver pathology, which was additionally prescribed essential phospholipid drugs (essentiale forte intravenously 10 ml/day and per os at 500 mg; essliver - per os 500 mg (1 cap) 3 times/day). Statistical methods : calculating the value of the average, the error of the average, the reliability of the differences according to the Student criterion, the percentage of differences between groups. Pharmacoepidemiological methods evaluated the hazard ratio and the odds ratio of the therapeutic effect of essential phospholipids. Results . Patients with liver lesions make up 19.5 % among patients with type 2 diabetes mellitus. Among them, patients with fatty hepatosis account for 3.3 %; with steatohepatitis - 3 %; with metabolic syndrome in combination with fatty hepatosis and steatohepatitis - 14.3 %. More than a 4-fold increase in relative chance and a 2-fold increase in relative risk of hypoglycemic effect in type 2 diabetes mellitus and hepatic steatosis is likely due to the fat-lysis and membranotropic effects of essential phospholipids on the liver. 1.7-fold increase in relative chance and 1.5-fold increase in relative risk of hypoglycemic effect in type 2 diabetes mellitus and steatohepatitis appears to be due to choleretic effect of essential phospholipids.

scholarly journals The hypoglycemic effect of freeze‐dried fermented mulberry mixed with soybean on type 2 diabetes mellitus

2021 ◽  
Author(s):  
Xiao‐Shan Long ◽  
Sen‐Tai Liao ◽  
Er‐Na Li ◽  
Dao‐Rui Pang ◽  
Qian Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Hypoglycemic Effect ◽  
Freeze Dried
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