scholarly journals Human Atrial Cell Models to Analyse the Effect of Extracellular Calcium on Action Potential Duration

2020 ◽  
Author(s):  
Fazeelat Mazhar ◽  
Chiara Bartolucci ◽  
Stefano Severi
Keyword(s):  
Action Potential ◽  
Action Potential Duration ◽  
Extracellular Calcium ◽  
Cell Models ◽  
Atrial Cell

The ex-vivo effects of thyroid status and extracellular calcium concentration on rat atrial and ventricular electrophysiology

1988 ◽  
Vol 66 (1) ◽  
pp. 90-94 ◽  
Author(s):  
R. W. Gristwood ◽  
A. L. Rothaul
Keyword(s):  
Action Potential ◽  
Action Potential Duration ◽  
Calcium Concentration ◽  
Ex Vivo ◽  
Additional Treatment ◽  
Extracellular Calcium ◽  
Krebs Solution ◽  
Thyroid Status ◽  
Extracellular Calcium Concentration ◽  
Atrial Electrophysiology

The purpose of this study was to explore the relationship between the thyroid status and both ventricular and atrial electrophysiology in the rat. The study was extended to consider the effects of altering the extracellular calcium concentration. The work was performed in two sections. First, hypothyroid animals were compared with euthyroid (untreated animals); second, hypothyroid animals were compared with hyperthyroid animals. Rats were rendered hypothyroid by pretreatment with the goitrogen methimazole and hyperthyroid by additional treatment with triiodothyronine. Action potential recordings were obtained using standard microelectrode techniques. Action potential measurements were made initially in a Krebs solution to which had been added 2.55 mM calcium (higher Ca Krebs solution) and at the end of each experiment after stabilization with Krebs solution to which had been added 1.28 mM calcium (lower Ca Krebs solution). Assessment of the change in action potential duration on transition from higher to lower Ca Krebs solution revealed that the euthyroid preparations demonstrated less prolongation of action potential duration than the hypothyroid group, and the hyperthyroid group showed hardly any response to reduction in calcium concentration.

Preceding Stimulus Frequency-Dependent Potentiation of the Postrest Shortening of the Action Potential Duration in Rabbits.

2000 ◽  
Vol 41 (4) ◽  
pp. 481-492
Author(s):  
Naohiko Takahashi ◽  
Morio Ito ◽  
Shuji Ishida ◽  
Takao Fujino ◽  
Mikiko Nakagawa ◽  
...  
Keyword(s):  
Action Potential ◽  
Action Potential Duration ◽  
Stimulus Frequency ◽  
Frequency Dependent ◽  
Preceding Stimulus

scholarly journals P496Remodeling of atrial action potential duration and atrial chamber deformation: a potential link in the development of atrial fibrillation?

2018 ◽  
Vol 114 (suppl_1) ◽  
pp. S120-S120
Author(s):  
L Sartiani ◽  
L Sartiani ◽  
M Cameli ◽  
L Dini ◽  
S Modillo ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Action Potential ◽  
Action Potential Duration ◽  
Potential Link
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