scholarly journals THE PRELIMINARY OBSERVATIONS ON CYTOPATHIC CHANGES INDUCED WITH NEWCASTLE DISEASE VIRUS IN HOG CHOLERA VIRUS-CARRIER CELL CULTURES

Uirusu ◽  
1968 ◽  
Vol 18 (4) ◽  
pp. 310-316
Author(s):  
Hisao IZAWA
Keyword(s):  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Cell Cultures ◽  
Newcastle Disease ◽  
Hog Cholera ◽  
Hog Cholera Virus ◽  
Carrier Cell ◽  
Virus Carrier

Interferon Induced by Endotoxin and Newcastle Disease Virus in Rabbit Macrophage and Kidney Cell Cultures

1973 ◽  
Vol 142 (2) ◽  
pp. 481-486 ◽  
Author(s):  
T. J. Smith ◽  
A. S. Lubiniecki ◽  
J. A. Armstrong ◽  
S. B. Russ
Keyword(s):  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Cell Cultures ◽  
Newcastle Disease ◽  
Kidney Cell

Antiviral Activity of Some Hydroxycoumarin Derivatives

1996 ◽  
Vol 51 (7-8) ◽  
pp. 558-562 ◽  
Author(s):  
Angel S. Galabov ◽  
Tanya Iosifova ◽  
Elka Vassileva ◽  
Ivanka Kostova
Keyword(s):  
Antiviral Activity ◽  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Virus Replication ◽  
Cell Cultures ◽  
Newcastle Disease ◽  
Inhibitory Effect ◽  
Marked Inhibitory Effect ◽  
Herpès Virus

Abstract Esculetin (6,7-dihydroxycoumarin) and its diacetate exhibited a marked inhibitory effect on Newcastle disease virus replication in cell cultures at concentrations of 36 jam and 62 jam, respectively. These compounds were selected from ten hydroxycoumarin derivatives through an in vitro antiviral screen involving viruses of the picorna-, orthomyxo-, paramyxo-, and herpes virus families.

scholarly journals Adaptation of the Newcastle Disease Virus to Cell Cultures for Enhancing Its Oncolytic Properties

Acta Naturae ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 66-73
Author(s):  
K. S. Yurchenko ◽  
Yi. Jing ◽  
A. M. Shestopalov
Keyword(s):  
Newcastle Disease Virus ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Disease Virus ◽  
Cell Cultures ◽  
Newcastle Disease ◽  
Human Cancer ◽  
Genetic Material ◽  
Human Tumor ◽  
Natural Strains

This study focuses on the adaptation of natural Newcastle disease virus (NDV) strains isolated from wild birds to human tumor cells. Many candidates for virotherapy are viruses pathogenic for human. During recombination of genetic material, there always exists a risk of getting a virus with an unstable genome. This problem can be solved by using natural apathogenic viruses as oncolytic agents. The Newcastle disease virus is the causative agent of contagious avian diseases. Its natural strains exhibit an antitumor effect and are considered safe for humans. As shown in earlier studies, the oncolytic properties of natural strains can be enhanced during adaptation to cell cultures, without interference in the virus genome. This study demonstrates that serial passaging increases the viral infectious titer in cancer cells. Moreover, the viability of tumor cells decreases post-infection when Newcastle disease virus strains are adapted to these cell cultures. The findings of this study complement the well-known data on the adaptation of the Newcastle disease virus to human cancer cells. Hence, it is possible to obtain a NDV strain with a more pronounced oncolytic potential during adaptation. This should be taken into account when choosing a strategy for designing anticancer drugs based on this virus.

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