scholarly journals Defects in Green Bodies during Powder Compression Process for Fabrication of Bulk Superconductors

2007 ◽  
Vol 42 (1) ◽  
pp. 18-23 ◽  
Author(s):  
Shinya NARIKI ◽  
Naomichi SAKAI ◽  
Izumi HIRABAYASHI
Keyword(s):  
Compression Process ◽  
Bulk Superconductors ◽  
Powder Compression

Modeling and Simulation of Pharmaceutical Powder Compaction

2012 ◽  
Vol 217-219 ◽  
pp. 1403-1406
Author(s):  
Guo Ning Si ◽  
Chen Lan
Keyword(s):  
Finite Element ◽  
Friction Coefficient ◽  
Powder Compaction ◽  
The Finite Element Method ◽  
Compression Process ◽  
Element Analysis ◽  
The Finite Element Analysis ◽  
Pharmaceutical Powder ◽  
Cap Model ◽  
Powder Compression

The finite element method was conducted to simulate the pharmaceutical powder compression process by using Drucker–Prager Cap model and elastic-plastic deformation theory. The effects of different friction coefficient on tablet property were systematically studied. The results show that the pressure-density curves shift towards right-hand side with slight decrease at smaller friction coefficient. The fluidity of powder remains the inverse decrease with the friction coefficient, and the density distribution changed more uniform. The maximum Mises stress becomes larger with the friction coefficient increased. The powder displacement decreases near die as the friction coefficient increasing. The research can both predict the tablet property and provide the theory reference for tablet practice production through the finite element analysis of pharmaceutical powder compaction.

Optimization of Microcrystalline Cellulose PH 101, Lactose, and Kollidon® K 30 To Obtain Co-Processed Excipient Through Spray Drying

2017 ◽  
Vol 7 (2) ◽  
Author(s):  
Kusuma P. ◽  
Syukri Y ◽  
Sholehuddin F. ◽  
Fazzri N. ◽  
Romdhonah . ◽  
...  
Keyword(s):  
Spray Drying ◽  
Microcrystalline Cellulose ◽  
Chemical Change ◽  
Direct Compression ◽  
Flow Properties ◽  
Scanning Calorimetry ◽  
Compression Process ◽  
Infrared Spectrophotometer ◽  
Physical Mixtures ◽  
Spray Dried

The most efficient tablet processing method is direct compression. For this method, the filler-binder can be made by coprocessing via spray drying method. The purpose of this study was to investigate the effect of spray dried co-processing on microcrystalline cellulose (MCC) PH 101, lactose and Kollidon® K 30 as well as to define the optimum proportions. Spray dried MCC PH 101, lactose, and Kollidon® K 30 were varied in 13 different mixture design proportions to obtain compact, free-flowing filler-binder co-processed excipients (CPE). Compactibility and flow properties became the key parameters to determine the optimum proportions of CPE that would be compared to their physical mixtures. The result showed that the optimum proportion of CPE had better compactibility and flow properties than the physical mixtures. The optimum CPE, consisting of only MCC PH 101 and Kollidon® K 30 without lactose, that were characterized using infrared spectrophotometer, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and scanning electron microscope (SEM) indicated no chemical change therein. Therefore, this study showed that spray dried MCC PH 101, lactose and Kollidon® K 30 could be one of the filler-binder alternatives for direct compression process.

scholarly journals Performance Study of Grass-Derived Nano-Cellulose and Polycaprolactone Composites for 3D Printing

2021 ◽  
Vol 11 (3) ◽  
pp. 1273
Author(s):  
Chen Feng ◽  
Jiping Zhou ◽  
Xiaodong Xu ◽  
Yani Jiang ◽  
Hongcan Shi ◽  
...  
Keyword(s):  
3D Printing ◽  
Mechanical Test ◽  
Chemical Properties ◽  
Test Results ◽  
Performance Study ◽  
Compression Process ◽  
Ansys Fluent ◽  
Nano Cellulose ◽  
Physical And Chemical ◽  
And Chemical Properties

In recent years, 3D printing has received increasing attention from researchers. This technology overcomes the limitations of traditional technologies by printing precise and personalized scaffold with arbitrary shapes, pore structures, and porosities for the applications in various tissues. The cellulose nanocrystal (CNC) is extracted from Humulus Japonicus (HJS) and mixed with poly(ε-caprolactone) (PCL) to prepare a series of CNC/PCL composites for printing. Based on the analysis of the physical and chemical properties of the series of the CNC/PCL composites, an optimal mass ratio of CNC to PCL was obtained. The Solidworks was used to simulate the stretching and compression process of the scaffolds with three different patterns under an external force. The flow of nutrient solution in the scaffolds with different patterns was simulated by ANSYS FLUENT, and then a new optimization scaffold pattern with a concave hexagon shape was advised based on the simulation results. Collectively, the mechanical test results of the material and scaffold confirmed that the optimal filling amount of the CNC was 5%, and the scaffold pattern with concave hexagon shape exhibited better mechanical properties and suitable for the transport of cells and nutrients, which is expected to be more widely used in 3D printing.

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