Development of a Windows-based, 3D FE model for analysis of powder compression process

2002 ◽  
Author(s):  
B. Mittal ◽  
L.T. Zikatanov ◽  
V. M. Puri and J. Xu
Keyword(s):  
Fe Model ◽  
Compression Process ◽  
Powder Compression

Modeling and Simulation of Pharmaceutical Powder Compaction

2012 ◽  
Vol 217-219 ◽  
pp. 1403-1406
Author(s):  
Guo Ning Si ◽  
Chen Lan
Keyword(s):  
Finite Element ◽  
Friction Coefficient ◽  
Powder Compaction ◽  
The Finite Element Method ◽  
Compression Process ◽  
Element Analysis ◽  
The Finite Element Analysis ◽  
Pharmaceutical Powder ◽  
Cap Model ◽  
Powder Compression

The finite element method was conducted to simulate the pharmaceutical powder compression process by using Drucker–Prager Cap model and elastic-plastic deformation theory. The effects of different friction coefficient on tablet property were systematically studied. The results show that the pressure-density curves shift towards right-hand side with slight decrease at smaller friction coefficient. The fluidity of powder remains the inverse decrease with the friction coefficient, and the density distribution changed more uniform. The maximum Mises stress becomes larger with the friction coefficient increased. The powder displacement decreases near die as the friction coefficient increasing. The research can both predict the tablet property and provide the theory reference for tablet practice production through the finite element analysis of pharmaceutical powder compaction.

Representation of bolted joints in a structure using finite element modelling and model updating

2020 ◽  
Vol 14 (3) ◽  
pp. 7141-7151 ◽  
Author(s):  
R. Omar ◽  
M. N. Abdul Rani ◽  
M. A. Yunus
Keyword(s):  
Finite Element ◽  
Dynamic Behaviour ◽  
Model Updating ◽  
Complex Structure ◽  
Bolted Joints ◽  
Model Parameters ◽  
Fe Model ◽  
Bolted Joint ◽  
Fe Modelling ◽  
Joint Structure

Efficient and accurate finite element (FE) modelling of bolted joints is essential for increasing confidence in the investigation of structural vibrations. However, modelling of bolted joints for the investigation is often found to be very challenging. This paper proposes an appropriate FE representation of bolted joints for the prediction of the dynamic behaviour of a bolted joint structure. Two different FE models of the bolted joint structure with two different FE element connectors, which are CBEAM and CBUSH, representing the bolted joints are developed. Modal updating is used to correlate the two FE models with the experimental model. The dynamic behaviour of the two FE models is compared with experimental modal analysis to evaluate and determine the most appropriate FE model of the bolted joint structure. The comparison reveals that the CBUSH element connectors based FE model has a greater capability in representing the bolted joints with 86 percent accuracy and greater efficiency in updating the model parameters. The proposed modelling technique will be useful in the modelling of a complex structure with a large number of bolted joints.

Optimization of Microcrystalline Cellulose PH 101, Lactose, and Kollidon® K 30 To Obtain Co-Processed Excipient Through Spray Drying

2017 ◽  
Vol 7 (2) ◽  
Author(s):  
Kusuma P. ◽  
Syukri Y ◽  
Sholehuddin F. ◽  
Fazzri N. ◽  
Romdhonah . ◽  
...  
Keyword(s):  
Spray Drying ◽  
Microcrystalline Cellulose ◽  
Chemical Change ◽  
Direct Compression ◽  
Flow Properties ◽  
Scanning Calorimetry ◽  
Compression Process ◽  
Infrared Spectrophotometer ◽  
Physical Mixtures ◽  
Spray Dried

The most efficient tablet processing method is direct compression. For this method, the filler-binder can be made by coprocessing via spray drying method. The purpose of this study was to investigate the effect of spray dried co-processing on microcrystalline cellulose (MCC) PH 101, lactose and Kollidon® K 30 as well as to define the optimum proportions. Spray dried MCC PH 101, lactose, and Kollidon® K 30 were varied in 13 different mixture design proportions to obtain compact, free-flowing filler-binder co-processed excipients (CPE). Compactibility and flow properties became the key parameters to determine the optimum proportions of CPE that would be compared to their physical mixtures. The result showed that the optimum proportion of CPE had better compactibility and flow properties than the physical mixtures. The optimum CPE, consisting of only MCC PH 101 and Kollidon® K 30 without lactose, that were characterized using infrared spectrophotometer, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and scanning electron microscope (SEM) indicated no chemical change therein. Therefore, this study showed that spray dried MCC PH 101, lactose and Kollidon® K 30 could be one of the filler-binder alternatives for direct compression process.

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