scholarly journals In vitro Assessment of Antioxidant and Antimicrobial Potential of Lactobacillus gasseri Strains Isolated from Human Milk and Infant Faeces

2020 ◽  
Vol 14 (2) ◽  
pp. 1305-1315
Author(s):  
Sonakshi Rastogi ◽  
Vineeta Mittal ◽  
Aditi Singh
Keyword(s):  
Human Milk ◽  
Lactobacillus Gasseri ◽  
Antimicrobial Potential ◽  
In Vitro Assessment

scholarly journals Production of multiple bacteriocins, including the novel bacteriocin gassericin M, by Lactobacillus gasseri LM19, a strain isolated from human milk

2019 ◽  
Author(s):  
Enriqueta Garcia-Gutierrez ◽  
Paula M. O’Connor ◽  
Ian J. Colquhoun ◽  
Natalia M. Vior ◽  
Juan Miguel Rodríguez ◽  
...  
Keyword(s):  
Human Milk ◽  
Human Colon ◽  
Short Chain Fatty Acids ◽  
Antagonistic Activity ◽  
The Novel ◽  
Lactobacillus Gasseri ◽  
Potential Synergy ◽  
Interesting Candidate ◽  
Health Promoting

AbstractBacteriocins are antimicrobial peptides produced by bacteria and their production by health-promoting microbes is regarded as a desirable probiotic trait. We found that Lactobacillus gasseri LM19, a strain isolated from human milk, exhibits antagonistic activity against different enteropathogens and produces several bacteriocins, including a novel bacteriocin, gassericin M. These bacteriocins were purified from culture and synthesised to investigate their activity and potential synergy. L. gasseri LM19 was tested in a complex environment mimicking human colon conditions where it not only survived but expressed the seven bacteriocin genes and produced short chain fatty acids. Metagenomic analysis of these in vitro colon cultures showed that co-inoculation of L. gasseri LM19 with Clostridium perfringens gave profiles with more similarity to controls than to vessels inoculated with C. perfringens alone. This makes L. gasseri LM19 an interesting candidate for further study for maintaining homeostasis in the gut environment.

scholarly journals In Vitro Assessment of Antimicrobial Potential of Ethanolic and Aqueous Extract of Against Some Highly Resistant Pathogens

2020 ◽  
Vol 6 (1) ◽  
pp. 3-9
Author(s):  
Yousra Shafiq ◽  
◽  
Muhammad Arif Asghar ◽  
Huma Ali ◽  
Saima Abedien ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Antimicrobial Potential ◽  
In Vitro Assessment

In vitro assessment of Labisia pumila and its constituents for interactions with CYPs, P-GP and PXR

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
VK Manda ◽  
OR Dale ◽  
C Awortwe ◽  
Z Ali ◽  
IA Khan ◽  
...  
Keyword(s):  
In Vitro Assessment ◽  
Labisia Pumila

Antimicrobial Potential of Benzamides and Derived Nanosystems for Controlling in vitro Biofilm Development on Medical Devices

2013 ◽  
Vol 17 (2) ◽  
pp. 162-175 ◽  
Author(s):  
Carmen Limban ◽  
Alexandru Mihai Grumezescu ◽  
Mariana Chirea ◽  
Lilia Matei ◽  
Mariana Carmen Chifiriuc
Keyword(s):  
Medical Devices ◽  
Antimicrobial Potential ◽  
Biofilm Development

Synthesis, Characterization, Antimicrobial and Antioxidant Potential of Diazenyl Chalcones

2018 ◽  
Vol 18 (10) ◽  
pp. 844-856 ◽  
Author(s):  
Harmeet Kaur ◽  
Balasubramanian Narasimhan
Keyword(s):  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Antioxidant Potential ◽  
Dilution Method ◽  
Dpph Assay ◽  
Antimicrobial Potential ◽  
Structural Conformation ◽  
Uv Visible ◽  
Tube Dilution Method

A series of diazenyl chalcones was prepared by base catalyzed Claisen-Schmidt condensation of synthesized hydroxy substituted acetophenone azo dye with various substituted aromatic/ heteroaromatic aldehydes. The structural conformation of synthesized chalcones was done by a number of physicochemical and spectral means like FTIR, UV-visible, mass, NMR spectroscopy and CHNS/O analysis. These diazenyl chalcones were assessed for their in vitro antimicrobial potential against several Gram-negative, Gram-positive bacterial and fungal strains by serial tube dilution method. The fluconazole and cefadroxil were used as standard drugs. The target compounds were also evaluated for their antioxidant potential by DPPH assay. (2E)-3-(2,4-Dichlorophenyl)-1-(4-((2,6- dihydroxyphenyl)diazenyl)phenyl)prop-2-en-1-one (C-7) had shown very good antimicrobial potential with MIC ranges from 3.79 to 15.76 μg/ml against most of the tested microorganisms. Most of the synthesized diazenyl chalcones were found to be active against B. subtilis. The (2E)-1-(5-((2-Chloro- 4-nitrophenyl)diazenyl)-2-hydroxyphenyl)-3-(2-hydroxynaphthalen-1-yl)prop-2-en-1-one (C-10) had shown high free radical-scavenging activity when compared with the ascorbic acid as the reference antioxidant.

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