scholarly journals Mesenchymal stromal cells from human umbilical cords display poor chondrogenic potential in scaffold-free three dimensional cultures

2016 ◽  
Vol 31 ◽  
pp. 407-424 ◽  
Author(s):  
A Islam ◽  
◽  
AK Hansen ◽  
C Mennan ◽  
I Martinez-Zubiaurre
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Three Dimensional ◽  
Chondrogenic Potential ◽  
Umbilical Cords

Adipose Tissue-Derived Stromal Cells Grown in Three-Dimensional Aliginate Constructs Display a Chondrogenic Phenotype

2000 ◽  
Author(s):  
Geoffrey R. Erickson ◽  
Jeffrey M. Gimble ◽  
Dawn Franklin ◽  
Farshid Guilak
Keyword(s):  
Articular Cartilage ◽  
Stromal Cells ◽  
Cartilage Damage ◽  
Donor Site ◽  
Subcutaneous Fat ◽  
Three Dimensional ◽  
Current Therapy ◽  
Chondrogenic Potential ◽  
Adipose Derived Stromal Cells ◽  
Chondrogenic Phenotype

Abstract Articular cartilage is the connective tissue that lines the surfaces of diarthrodial joints in the human body. Because cartilage is avascular, aneural, and alymphatic, it has a limited capacity for repair. Techniques such as microfracture, transplantation of autologous cartilage, and allograft or xenograft transplantations have not proven fully effective in treating cartilage damage. Current therapy is focusing on cell-based treatments such as autologous chondrocyte transplantation [1,2]. However, this method faces several limitations, as the donor site can provide a limited number of cells and the harvesting procedure itself may cause significant local morbidity. The goal of this study was to examine the chondrogenic potential of an autologous source of undifferentiated stromal cells derived from subcutaneous fat. It has been shown that chondrocytes embedded in a three-dimensional matrix retain a differentiated phenotype and produce cartilage-associated proteins [3]. In addition, it has been shown that alginate or agarose can support the formation of an extracellular matrix over time [4,5]. The goal of this study was to examine the chondrogenic potential of adipose-derived stromal cells with the ultimate goal of developing a “tissue engineering” method to regenerate articular cartilage.

scholarly journals Challenges Toward the Identification of Predictive Markers for Human Mesenchymal Stromal Cells Chondrogenic Potential

2019 ◽  
Vol 8 (2) ◽  
pp. 194-204 ◽  
Author(s):  
Chiara Stüdle ◽  
Paola Occhetta ◽  
Florian Geier ◽  
Arne Mehrkens ◽  
Andrea Barbero ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Predictive Markers ◽  
Human Mesenchymal Stromal Cells ◽  
Chondrogenic Potential

The Stiffness and Structure of Three-Dimensional Printed Hydrogels Direct the Differentiation of Mesenchymal Stromal Cells Toward Adipogenic and Osteogenic Lineages

2015 ◽  
Vol 21 (3-4) ◽  
pp. 740-756 ◽  
Author(s):  
Daniela F. Duarte Campos ◽  
Andreas Blaeser ◽  
Anne Korsten ◽  
Sabine Neuss ◽  
Jörg Jäkel ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Three Dimensional

scholarly journals Three-dimensional cartilage-derived construct derived from multipotent mesenchymal stromal cells

2020 ◽  
Vol 22 ◽  
pp. 02014
Author(s):  
Oleg Makeyev ◽  
Arteom Korotkov ◽  
Svetlana Kostyukova ◽  
Daria Sichkar ◽  
Elizaveta Yakovleva
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Three Dimensional ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Cartilage Tissue ◽  
Cartilage Surface ◽  
Initial Stage ◽  
Conventional Drug ◽  
Surgical Methods ◽  
Further Development

Damage to the cartilage surface of the joints is a common pathology. Conventional drug therapies are effective only at the initial stage of the disease and only slow down the further development of the disease. In subsequent stages, it is necessary to apply surgical methods from replacing a defect to complete prosthetics of a damaged joint. In order to replace defects in cartilage tissue, a three-dimensional bioequivalent was created based on autologous multipotent mesenchymal stromal cells.

scholarly journals Comparison of Chondrogenic Potential in Equine Mesenchymal Stromal Cells Derived from Adipose Tissue and Bone Marrow

2008 ◽  
Vol 37 (8) ◽  
pp. 713-724 ◽  
Author(s):  
MARTIN A. VIDAL ◽  
SANDRA O. ROBINSON ◽  
MANDI J. LOPEZ ◽  
DANIEL B. PAULSEN ◽  
OLGA BORKHSENIOUS ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Adipose Tissue ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Chondrogenic Potential
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