Role of solute carrier transporters in pancreatic cancer: a review

2014 ◽  
Vol 15 (8) ◽  
pp. 1133-1145 ◽  
Author(s):  
Radmila Lemstrová ◽  
Pavel Souček ◽  
Bohuslav Melichar ◽  
Beatrice Mohelnikova-Duchonova
Keyword(s):  
Pancreatic Cancer ◽  
Solute Carrier Transporters ◽  
Solute Carrier

scholarly journals Role of ATP-Binding Cassette and Solute Carrier Transporters in Erlotinib CNS Penetration and Intracellular Accumulation

2010 ◽  
Vol 17 (1) ◽  
pp. 89-99 ◽  
Author(s):  
Mohamed A. Elmeliegy ◽  
Angel M. Carcaboso ◽  
Michael Tagen ◽  
Feng Bai ◽  
Clinton F. Stewart
Keyword(s):  
Atp Binding ◽  
Intracellular Accumulation ◽  
Solute Carrier Transporters ◽  
Solute Carrier ◽  
Cns Penetration ◽  
Atp Binding Cassette

The association between the expression of solute carrier transporters and the prognosis of pancreatic cancer

2013 ◽  
Vol 72 (3) ◽  
pp. 669-682 ◽  
Author(s):  
Beatrice Mohelnikova-Duchonova ◽  
Veronika Brynychova ◽  
Viktor Hlavac ◽  
Matej Kocik ◽  
Martin Oliverius ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Solute Carrier Transporters ◽  
Solute Carrier

PET/CT IN THE DIAGNOSIS OF PANCREATIC CANCER: LITERATURE REVIEW

2018 ◽  
pp. 57-67
Author(s):  
P. E. Tulin ◽  
M. B. Dolgushin ◽  
D. I. Nevzorov ◽  
P. V. Kochergin ◽  
Yu. I. Patyutko
Keyword(s):  
Pancreatic Cancer ◽  
Literature Review ◽  
Pancreatic Neoplasms ◽  
Poor Prognosis ◽  
Modern Imaging ◽  
Pet Ct

Pancreatic cancer has a poor prognosis, often because most pancreatic neoplasms are found to be unresectable at diagnosis. Early staging of the tumor process can change the tactics of treatment and affect the survival of patients. The purpose of this review is to provide an overview of pancreatic cancer and the role of modern imaging in its diagnosis with an emphasis on PET/CT with a various radiopharmaceuticals.

Role of myeloperoxidase in relationship between smoking and risk of pancreatic cancer

2012 ◽  
Vol 32 (2) ◽  
pp. 183-185
Author(s):  
Xin-xin FU ◽  
Zhao-shen LI ◽  
Zhen-dong JIN ◽  
Hai-tao CHEN ◽  
Wei ZHU ◽  
...  
Keyword(s):  
Pancreatic Cancer

Diagnostic pancreatic cancer: the role of percutaneous biopsy and CT

2007 ◽  
Vol 31 (3) ◽  
pp. 221
Author(s):  
Z. Amin ◽  
B. Theis ◽  
R.C.G. Russell ◽  
C. House ◽  
M. Novelli ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Percutaneous Biopsy

scholarly journals A Proteomic Study on the Personalized Protein Corona of Liposomes. Relevance for Early Diagnosis of Pancreatic DUCTAL Adenocarcinoma and Biomarker Detection

2021 ◽  
Vol 2 (2) ◽  
pp. 82-93
Author(s):  
Luca Digiacomo ◽  
Francesca Giulimondi ◽  
Daniela Pozzi ◽  
Alessandro Coppola ◽  
Vincenzo La Vaccara ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Early Diagnosis ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Protein Corona ◽  
Detection Sensitivity ◽  
Ductal Adenocarcinoma ◽  
Protein Biomarkers ◽  
Ca 19.9 ◽  
Proteomic Study

Due to late diagnosis, high incidence of metastasis, and poor survival rate, pancreatic cancer is one of the most leading cause of cancer-related death. Although manifold recent efforts have been done to achieve an early diagnosis of pancreatic cancer, CA-19.9 is currently the unique biomarker that is adopted for the detection, despite its limits in terms of sensitivity and specificity. To identify potential protein biomarkers for pancreatic ductal adenocarcinoma (PDAC), we used three model liposomes as nanoplatforms that accumulate proteins from human plasma and studied the composition of this biomolecular layer, which is known as protein corona. Indeed, plasma proteins adsorb on nanoparticle surface according to their abundance and affinity to the employed nanomaterial, thus even small differences between healthy and PDAC protein expression levels can be, in principle, detected. By mass spectrometry experiments, we quantified such differences and identified possible biomarkers for PDAC. Some of them are already known to exhibit different expressions in PDAC proteomes, whereas the role of other relevant proteins is still not clear. Therefore, we predict that the employment of nanomaterials and their protein corona may represent a useful tool to amplify the detection sensitivity of cancer biomarkers, which may be used for the early diagnosis of PDAC, with clinical implication for the subsequent therapy in the context of personalized medicine.

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