The Role of Ferroptosis Regulators in the Prognosis, Immune Microenvironment and Gemcitabine Resistance of Pancreatic Cancer

2020 ◽  
Author(s):  
Rong Tang ◽  
Jie Hua ◽  
Jin Xu ◽  
Chen Liang ◽  
Qingcai Meng ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Immune Microenvironment ◽  
Gemcitabine Resistance

scholarly journals The role of GLI-SOX2 signaling axis for gemcitabine resistance in pancreatic cancer

Oncogene ◽  
2018 ◽  
Vol 38 (10) ◽  
pp. 1764-1777 ◽  
Author(s):  
Yanfei Jia ◽  
Dongsheng Gu ◽  
Jun Wan ◽  
Beiqin Yu ◽  
Xiaoli Zhang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Gemcitabine Resistance ◽  
Signaling Axis

scholarly journals The Role of Platelet-Derived ADP and ATP in Promoting Pancreatic Cancer Cell Survival and Gemcitabine Resistance

Cancers ◽  
2017 ◽  
Vol 9 (12) ◽  
pp. 142 ◽  
Author(s):  
Omar Elaskalani ◽  
Marco Falasca ◽  
Niamh Moran ◽  
Michael Berndt ◽  
Pat Metharom
Keyword(s):  
Pancreatic Cancer ◽  
Cell Survival ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Gemcitabine Resistance ◽  
Cancer Cell Survival

scholarly journals The role of ferroptosis regulators in the prognosis, immune activity and gemcitabine resistance of pancreatic cancer

2020 ◽  
Vol 8 (21) ◽  
pp. 1347-1347
Author(s):  
Rong Tang ◽  
Jie Hua ◽  
Jin Xu ◽  
Chen Liang ◽  
Qingcai Meng ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Immune Activity ◽  
Gemcitabine Resistance

scholarly journals Linc-DYNC2H1-4 promotes EMT and CSC phenotypes by acting as a sponge of miR-145 in pancreatic cancer cells

2017 ◽  
Vol 8 (7) ◽  
pp. e2924-e2924 ◽  
Author(s):  
Yuran Gao ◽  
Zhicheng Zhang ◽  
Kai Li ◽  
Liying Gong ◽  
Qingzhu Yang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Ectopic Expression ◽  
Pancreatic Cancer Cell Line ◽  
Mesenchymal Transition ◽  
Gemcitabine Resistance ◽  
Pancreatic Cancer Cells ◽  
Sense Strand ◽  
The Impact

AbstractThe acquisition of epithelial–mesenchymal transition (EMT) and/or existence of a sub-population of cancer stem-like cells (CSC) are associated with malignant behavior and chemoresistance. To identify which factor could promote EMT and CSC formation and uncover the mechanistic role of such factor is important for novel and targeted therapies. In the present study, we found that the long intergenic non-coding RNA linc-DYNC2H1-4 was upregulated in pancreatic cancer cell line BxPC-3-Gem with acquired gemcitabine resistance. Knockdown of linc-DYNC2H1-4 decreased the invasive behavior of BxPC-3-Gem cells while ectopic expression of linc-DYNC2H1-4 promoted the acquisition of EMT and stemness of the parental sensitive cells. Linc-DYNC2H1-4 upregulated ZEB1, the EMT key player, which led to upregulation and downregulation of its targets vimentin and E-cadherin respectively, as well as enhanced the expressions of CSC makers Lin28, Nanog, Sox2 and Oct4. Linc-DYNC2H1-4 is mainly located in the cytosol. Mechanically, it could sponge miR-145 that targetsZEB1,Lin28,Nanog,Sox2,Oct4to restore these EMT and CSC-associated genes expressions. We proved thatMMP3, the nearby gene of linc-DYNC2H1-4 in the sense strand, was also a target of miR-145. Downregulation ofMMP3by miR-145 was reverted by linc-DYNC2H1-4, indicating that competing with miR-145 is one of the mechanisms for linc-DYNC2H1-4 to regulateMMP3. In summary, our results explore the important role of linc-DYNC2H1-4 in the acquisition of EMT and CSC, and the impact it has on gemcitabine resistance in pancreatic cancer cells.

The role of IFIT3 in gemcitabine resistance of pancreatic cancer

Pancreatology ◽  
2019 ◽  
Vol 19 ◽  
pp. S77
Author(s):  
Zhefang Wang ◽  
Qin Jie ◽  
Jiangang Zhao ◽  
Jiahui Li ◽  
Marie Popp ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Gemcitabine Resistance

miRNAs and chemoresistance of pancreatic cancer: the role of miR-125b and miR-100 in gemcitabine resistance

Pancreatology ◽  
2015 ◽  
Vol 15 (3) ◽  
pp. S27-S28
Author(s):  
Felix Lämmerhirt ◽  
Markus M. Lerch ◽  
Frank Ulrich Weiss
Keyword(s):  
Pancreatic Cancer ◽  
Gemcitabine Resistance

Abstract 4438: Role of post translational modification of PAF1/PD2 in gemcitabine resistance of pancreatic cancer

2019 ◽  
Author(s):  
Sanchita Rauth ◽  
Saswati Karmakar ◽  
Ashu Shah ◽  
Rama Krishna Nimmakayala ◽  
Rakesh Bhatia ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Post Translational Modification ◽  
Gemcitabine Resistance

scholarly journals The Human Microbiomes in Pancreatic Cancer: Towards Evidence-Based Manipulation Strategies?

2021 ◽  
Vol 22 (18) ◽  
pp. 9914
Author(s):  
Giovanni Brandi ◽  
Silvia Turroni ◽  
Florencia McAllister ◽  
Giorgio Frega
Keyword(s):  
Pancreatic Cancer ◽  
Therapeutic Approaches ◽  
Immune Microenvironment ◽  
Essential Components ◽  
Tumor Immune Microenvironment ◽  
Current Therapies ◽  
Treatment Responses ◽  
The One ◽  
Resistance To Chemotherapy

Recent pieces of evidence have emerged on the relevance of microorganisms in modulating responses to anticancer treatments and reshaping the tumor-immune microenvironment. On the one hand, many studies have addressed the role of the gut microbiota, providing interesting correlative findings with respect to etiopathogenesis and treatment responses. On the other hand, intra-tumoral bacteria are being recognized as intrinsic and essential components of the cancer microenvironment, able to promote a plethora of tumor-related aspects from cancer growth to resistance to chemotherapy. These elements will be probably more and more valuable in the coming years in early diagnosis and risk stratification. Furthermore, microbial-targeted intervention strategies may be used as adjuvants to current therapies to improve therapeutic responses and overall survival. This review focuses on new insights and therapeutic approaches that are dawning against pancreatic cancer: a neoplasm that arises in a central metabolic “hub” interfaced between the gut and the host.

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