Use of mathematical models to understand anticancer drug delivery and its effect on solid tumors

2011 ◽  
Vol 12 (9) ◽  
pp. 1337-1348 ◽  
Author(s):  
Cong Liu ◽  
J Krishnan ◽  
Justin Stebbing ◽  
Xiao Yun Xu
Keyword(s):  
Drug Delivery ◽  
Mathematical Models ◽  
Solid Tumors ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery

Hydrolytically Degradable Polymer Micelles for Anticancer Drug Delivery to Solid Tumors

2012 ◽  
Vol 213 (8) ◽  
pp. 858-867 ◽  
Author(s):  
Petr Chytil ◽  
Tomáš Etrych ◽  
Libor Kostka ◽  
Karel Ulbrich
Keyword(s):  
Drug Delivery ◽  
Solid Tumors ◽  
Anticancer Drug ◽  
Polymer Micelles ◽  
Anticancer Drug Delivery ◽  
Degradable Polymer

HER2-Mediated Anticancer Drug Delivery: Strategies to Prepare Targeting Ligands Highly Specific for the Receptor

2015 ◽  
Vol 22 (21) ◽  
pp. 2525-2538 ◽  
Author(s):  
Enrica Calce ◽  
Luca Monfregola ◽  
Michele Saviano ◽  
Stefania De Luca
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Delivery Strategies

Advances in Nanoparticles as Anticancer Drug Delivery Vector: Need of this Century

2020 ◽  
Vol 26 (15) ◽  
pp. 1637-1649 ◽  
Author(s):  
Imran Ali ◽  
Sofi D. Mukhtar ◽  
Heyam S. Ali ◽  
Marcus T. Scotti ◽  
Luciana Scotti
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Medical Science ◽  
Drug Carriers ◽  
Anticancer Drug Delivery ◽  
Ph Values ◽  
Delivery Vector ◽  
Future Challenges ◽  
Smart Drug ◽  
Smart Drug Delivery

Background: Nanotechnology has contributed a great deal to the field of medical science. Smart drugdelivery vectors, combined with stimuli-based characteristics, are becoming increasingly important. The use of external and internal stimulating factors can have enormous benefits and increase the targeting efficiency of nanotechnology platforms. The pH values of tumor vascular tissues are acidic in nature, allowing the improved targeting of anticancer drug payloads using drug-delivery vectors. Nanopolymers are smart drug-delivery vectors that have recently been developed and recommended for use by scientists because of their potential targeting capabilities, non-toxicity and biocompatibility, and make them ideal nanocarriers for personalized drug delivery. Method: The present review article provides an overview of current advances in the use of nanoparticles (NPs) as anticancer drug-delivery vectors. Results: This article reviews the molecular basis for the use of NPs in medicine, including personalized medicine, personalized therapy, emerging vistas in anticancer therapy, nanopolymer targeting, passive and active targeting transports, pH-responsive drug carriers, biological barriers, computer-aided drug design, future challenges and perspectives, biodegradability and safety. Conclusions: This article will benefit academia, researchers, clinicians, and government authorities by providing a basis for further research advancements.

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