Influence of genetic polymorphisms, smoking, gender and age on CYP1A2 activity in a Turkish population

2009 ◽  
Vol 10 (5) ◽  
pp. 769-778 ◽  
Author(s):  
Arzu Gunes ◽  
Gul Ozbey ◽  
Elif Hilal Vural ◽  
Canan Uluoglu ◽  
Maria Gabriella Scordo ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Turkish Population ◽  
Cyp1a2 Activity ◽  
Gender And Age

Impact of Smoking, Smoking Cessation, and Genetic Polymorphisms on CYP1A2 Activity and Inducibility

2011 ◽  
Vol 90 (1) ◽  
pp. 117-125 ◽  
Author(s):  
M Dobrinas ◽  
J Cornuz ◽  
B Oneda ◽  
M Kohler Serra ◽  
M Puhl ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Genetic Polymorphisms ◽  
Cyp1a2 Activity

scholarly journals Effects of Genetic Polymorphisms of Drug Transporter ABCB1 (MDR1) and Cytochrome P450 Enzymes CYP2A6, CYP2B6 on Nicotine Addiction and Smoking Cessation

2020 ◽  
Vol 11 ◽  
Author(s):  
Ahmet Muderrisoglu ◽  
Elif Babaoglu ◽  
Elif Tugce Korkmaz ◽  
Mert C. Ongun ◽  
Erdem Karabulut ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Cytochrome P450 ◽  
Drug Treatment ◽  
Genetic Polymorphisms ◽  
Genetic Variants ◽  
Smoking Status ◽  
Turkish Population ◽  
Drug Transporter ◽  
Cytochrome P450 Enzymes ◽  
Quit Smoking

ObjectivesTo determine the effects of genetic polymorphisms of ABCB1 (MDR1), CYP2A6, CYP2B6 on smoking status, and clinical outcomes of smoking cessation therapies in a Turkish population.Methods130 smokers and 130 non-smokers were recruited. Individuals who never smoked were described as non-smokers. 130 smokers were treated with nicotine replacement therapy (NRT) (n = 40), bupropion (n = 47), bupropion + NRT (n = 15), and varenicline (n = 28). Smokers were checked by phone after 12 weeks of treatment whether they were able to quit smoking or not. Genotyping and phenotyping were performed.ResultsCessation rates were as follows; 20.0% for NRT, 29.8% for bupropion, 40.0% for bupropion + NRT, 57.1% for varenicline (p = 0.013). The frequency of ABCB1 1236TT-2677TT-3435TT haplotype was significantly higher in non-smokers as compared to smokers (21.5% vs. 10.8, respectively; p = 0.018). Neither smoking status nor smoking cessation rates were associated with genetic variants of CYP2A6 (p = 0.652, p = 0.328, respectively), or variants of CYP2B6 (p = 0.514, p = 0.779, respectively).ConclusionGenetic variants of the drug transporter ABCB1 and the 1236TT-2677TT-3435TT haplotype was significantly associated with non-smoking status. Neither ABCB1 nor CYP2A6, CYP2B6 genetic variants were associated with smoking cessation rates at the 12th week of drug treatment.

Analysis of paraoxonase 1 (PON1) genetic polymorphisms and activities as risk factors for ischemic stroke in Turkish population

2009 ◽  
Vol 27 (8) ◽  
pp. 558-567 ◽  
Author(s):  
Birsen Can Demirdöğen ◽  
Şeref Demirkaya ◽  
Aysun Türkanoğlu ◽  
Semai Bek ◽  
Emel Arınç ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Genetic Polymorphisms ◽  
Turkish Population ◽  
Paraoxonase 1

Glutathione-S-transferase M1 and T1 Genetic Polymorphisms and the Risk of Cataract Development: A Study in the Turkish Population

2007 ◽  
Vol 32 (5) ◽  
pp. 447-454 ◽  
Author(s):  
Mehmet Güven ◽  
Mustafa Ünal ◽  
Ahmet Sarıcı ◽  
Ahmet Özaydın ◽  
Bahadır Batar ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Turkish Population ◽  
Glutathione S Transferase ◽  
Cataract Development

Importance of NOS3 Genetic Polymorphisms in the Risk of Development of Ischemic Stroke in the Turkish Population

2014 ◽  
Vol 18 (12) ◽  
pp. 797-803 ◽  
Author(s):  
Aysun Türkanoğlu Özçelik ◽  
Birsen Can Demirdöğen ◽  
Şeref Demirkaya ◽  
Orhan Adalı
Keyword(s):  
Ischemic Stroke ◽  
Genetic Polymorphisms ◽  
Turkish Population

scholarly journals The effects of gender and age on forensic personal identification from frontal sinus in a Turkish population

2017 ◽  
Vol 38 (1) ◽  
pp. 41-47 ◽  
Author(s):  
Ertugrul Tatlisumak ◽  
Mahmut Asirdizer ◽  
Aydin Bora ◽  
Yavuz Hekimoglu ◽  
Yasin Etli ◽  
...  
Keyword(s):  
Frontal Sinus ◽  
Turkish Population ◽  
Personal Identification ◽  
Gender And Age

scholarly journals The effects of genetic polymorphisms of APOE on circulating lipid levels in middle-aged and elderly chinese Fujian Han population: toward age- and sex-personalized management

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Xiaofeng Liu ◽  
Qingwen Lin ◽  
Kengna Fan ◽  
Minjie Tang ◽  
Weiqing Zhang ◽  
...  
Keyword(s):  
At Risk ◽  
Genetic Polymorphisms ◽  
Serum Lipids ◽  
Combined Effects ◽  
Middle Aged ◽  
Han Population ◽  
Risk Levels ◽  
Elderly Males ◽  
Gender And Age ◽  
Elderly Chinese

Abstract Background Increased evidence has reported the association of genetic polymorphisms of Apolipoprotein E (APOE) with serum lipids. However, few studies have explored the combined effects of APOE, gender, and age. Methods A total of 1,419 middle-aged and elderly subjects were randomly selected and studied. The APOE genotypes and the serum lipids were detected. The effects of APOE, gender, and age on serum lipids were preliminarily observed in general. The subjects were then divided into the middle-aged group (40–64 years old) and the elderly group (≥ 65 years old), for both males and females, to explore the combined effects of the APOE, gender, and age on serum lipids. Finally, a multivariate logistic regression model was used to evaluate the associations between the APOE allele carriers and the at-risk levels of dyslipidemia. Results The serum TC, LDL-C, and ApoB in the ε2 carriers were lower than the ε3 carriers (all P < 0.05), and there was no significant difference in the ε4 carriers compared to the ε3 carriers in general (all P > 0.05). The serum LDL-C and ApoB of the ε2 carriers were lower than the noncarriers in the middle-aged and elderly males (all P < 0.05). The serum TC in the ε2 carriers was lower than the noncarriers only in middle-aged males (P < 0.05). As to the levels of serum HDL-C and ApoA1, the ε2 carriers were higher than the noncarriers in middle-aged females (all P < 0.05), and the ε4 carriers were lower than noncarriers in middle-aged males (P < 0.05). Especially, the serum TG in the ε4 carriers was significantly higher than the noncarriers in elderly females. The logistic regression analysis indicated that the ε2 carriers were less likely to have at-risk levels of high LDL-C in middle-aged and elderly males (all P < 0.05) versus low HDL-C in middle-aged females (P < 0.05). In contrast, the ε4 carriers were more likely to have at-risk levels of high TG in elderly females (P < 0.05). Conclusions The effects of the genetic polymorphisms of APOE on the serum lipids were both gender- and age-dependent in the middle-aged and elderly Chinese Fujian Han population.

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