Analysis of paraoxonase 1 (PON1) genetic polymorphisms and activities as risk factors for ischemic stroke in Turkish population

2009 ◽  
Vol 27 (8) ◽  
pp. 558-567 ◽  
Author(s):  
Birsen Can Demirdöğen ◽  
Şeref Demirkaya ◽  
Aysun Türkanoğlu ◽  
Semai Bek ◽  
Emel Arınç ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Genetic Polymorphisms ◽  
Turkish Population ◽  
Paraoxonase 1

Importance of NOS3 Genetic Polymorphisms in the Risk of Development of Ischemic Stroke in the Turkish Population

2014 ◽  
Vol 18 (12) ◽  
pp. 797-803 ◽  
Author(s):  
Aysun Türkanoğlu Özçelik ◽  
Birsen Can Demirdöğen ◽  
Şeref Demirkaya ◽  
Orhan Adalı
Keyword(s):  
Ischemic Stroke ◽  
Genetic Polymorphisms ◽  
Turkish Population

scholarly journals Genetic polymorphisms and related risk factors of ischemic stroke in a Mongolian population in China

2017 ◽  
Vol 21 (5) ◽  
pp. 581-587 ◽  
Author(s):  
Q. Wu ◽  
H. Wu ◽  
Yu. L. Orlov ◽  
G. Gegentana ◽  
W. Huo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Genetic Polymorphisms ◽  
Related Risk

scholarly journals Association analysis of Glutathione S-transferase omega-1 and omega-2 genetic polymorphisms and ischemic stroke risk in a Turkish population

2018 ◽  
Vol 41 (2) ◽  
pp. 118-124 ◽  
Author(s):  
Esra Bilgin ◽  
Birsen Can Demirdöğen ◽  
Aysun Türkanoğlu Özçelik ◽  
Şeref Demirkaya ◽  
Orhan Adalı
Keyword(s):  
Ischemic Stroke ◽  
Genetic Polymorphisms ◽  
Association Analysis ◽  
Stroke Risk ◽  
Turkish Population ◽  
Glutathione S Transferase ◽  
Ischemic Stroke Risk

The relation between hyperhomocysteinemia and the intima-media complex thickness in common carotid artery, as risk factors for ischemic stroke

2018 ◽  
Vol 31 (06) ◽  
Author(s):  
Monika Chorazy ◽  
Dominika Jakubowicz-Lachowska ◽  
Michal Szczepanski ◽  
Katarzyna Krystyna Snarska ◽  
Agata Krajewska ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Carotid Artery ◽  
Common Carotid Artery

Risk Factors of Recurrent Ischemic Events after Acute Noncardiogenic Ischemic Stroke

2020 ◽  
Vol 25 (45) ◽  
pp. 4827-4834 ◽  
Author(s):  
Limin Zhang ◽  
Xingang Li ◽  
Dongzhi Wang ◽  
Hong Lv ◽  
Xuezhong Si ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Ischemic Stroke ◽  
Operating Characteristic ◽  
Control Group ◽  
Case Group ◽  
Stroke Patients ◽  
Clopidogrel Therapy ◽  
Ischemic Events

Background: A considerable proportion of acute noncardiogenic ischemic stroke patients continue to experience recurrent ischemic events after standard therapy. Aim: We aimed to identify risk factors for recurrent ischemic event prediction at an early stage. Methods : 286 non-cardioembolic ischemic stroke patients with the onset of symptoms within 24 hours were enrolled. Vascular risk factors, routine laboratory data on admission, thromboelastography test seven days after clopidogrel therapy and any recurrent events within one year were assessed. Patients were divided into case group (patients with clinical adverse events, including ischemic stokes, transient ischemic attack, myocardial infarction and vascular related mortality) and control group (events-free patients). The risk of the recurrent ischemic events was determined by the receiver operating characteristic curve and multivariable logistic regression analysis. Results: Clinical adverse events were observed in 43 patients (case group). The mean levels of Mean Platelet Volume (MPV), Platelet/Lymphocyte Ratio (PLR), Lymphocyte Count (LY) and Fibrinogen (Fib) on admission were significantly higher in the case group as compared to the control group (P<0.001). Seven days after clopidogrel therapy, the ADP-induced platelet inhibition rate (ADP%) level was lower in the case group, while the Maximum Amplitude (MA) level was higher in the case group as compared to the control group (P<0.01). The Area Under the Curve (AUC) of receiver operating characteristic(ROC) curve of LY, PLR, , Fib, MA, ADP% and MPV were 0.602, 0.614, 0.629, 0.770, 0.800 and 0.808, respectively. The logistic regression analysis showed that MPV, ADP% and MA were indeed predictive factors. Conclusion: MPV, ADP% and MA were risk factors of recurrent ischemic events after acute noncardiogenic ischemic stroke. Urgent assessment and individual drug therapy should be offered to these patients as soon as possible.

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