Gold nanorods and curcumin-loaded nanomicelles for efficient in vivo photothermal therapy of Barrett's esophagus

Nanomedicine ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. 1723-1733 ◽  
Author(s):  
Robert CG Martin ◽  
Erica Locatelli ◽  
Yan Li ◽  
Weizhong Zhang ◽  
Suping Li ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Gold Nanorods ◽  
Barrett's Esophagus ◽  
Photothermal Therapy

Methylene Blue Staining of Dysplastic and Nondysplastic Barrett's Esophagus: An In Vivo and Ex Vivo Study

Endoscopy ◽  
2001 ◽  
Vol 33 (5) ◽  
pp. 391-400 ◽  
Author(s):  
M. I. Canto ◽  
S. Setrakian ◽  
J. E. Willis ◽  
A. Chak ◽  
R. E. Petras ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Ex Vivo ◽  
Blue Staining ◽  
Ex Vivo Study

Tu1542 Diagnostic Performance of In-Vivo Volumetric LASER Endomicroscopy for Detection of Barrett's Esophagus Dysplasia

2015 ◽  
Vol 81 (5) ◽  
pp. AB502 ◽  
Author(s):  
Cadman L. Leggett ◽  
Daniel K. Chan ◽  
Emmanuel C. Gorospe ◽  
Akhil Nehra ◽  
Marlys Anderson ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Diagnostic Performance

Mo1971 Expert Consensus on In-Vivo Volumetric Laser Endomicroscopy Features of Barrett's Esophagus Dysplasia

2017 ◽  
Vol 85 (5) ◽  
pp. AB500
Author(s):  
Amrit K. Kamboj ◽  
Daniel K. Chan ◽  
Liam Zakko ◽  
Kavel Visrodia ◽  
Fouad Otaki ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Expert Consensus

Sa1831 Image-Guided Raman Spectroscopy for Real-Time In Vivo Diagnosis of Barrett's Esophagus During Endoscopic Examination

2012 ◽  
Vol 142 (5) ◽  
pp. S-336 ◽  
Author(s):  
Mads Sylvest Bergholt ◽  
Wei Zheng ◽  
Khek-Yu Ho ◽  
Ming Teh ◽  
Khay Guan Yeoh ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Real Time ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Endoscopic Examination ◽  
Image Guided ◽  
In Vivo Diagnosis

scholarly journals Efficacy, long-term toxicity, and mechanistic studies of gold nanorods photothermal therapy of cancer in xenograft mice

2017 ◽  
Vol 114 (15) ◽  
pp. E3110-E3118 ◽  
Author(s):  
Moustafa R. K. Ali ◽  
Mohammad Aminur Rahman ◽  
Yue Wu ◽  
Tiegang Han ◽  
Xianghong Peng ◽  
...  
Keyword(s):  
Cell Death ◽  
Mechanism Of Action ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Mouse Tumor ◽  
Maximal Induction

Gold nanorods (AuNRs)-assisted plasmonic photothermal therapy (AuNRs-PPTT) is a promising strategy for combating cancer in which AuNRs absorb near-infrared light and convert it into heat, causing cell death mainly by apoptosis and/or necrosis. Developing a valid PPTT that induces cancer cell apoptosis and avoids necrosis in vivo and exploring its molecular mechanism of action is of great importance. Furthermore, assessment of the long-term fate of the AuNRs after treatment is critical for clinical use. We first optimized the size, surface modification [rifampicin (RF) conjugation], and concentration (2.5 nM) of AuNRs and the PPTT laser power (2 W/cm2) to achieve maximal induction of apoptosis. Second, we studied the potential mechanism of action of AuNRs-PPTT using quantitative proteomic analysis in mouse tumor tissues. Several death pathways were identified, mainly involving apoptosis and cell death by releasing neutrophil extracellular traps (NETs) (NETosis), which were more obvious upon PPTT using RF-conjugated AuNRs (AuNRs@RF) than with polyethylene glycol thiol-conjugated AuNRs. Cytochrome c and p53-related apoptosis mechanisms were identified as contributing to the enhanced effect of PPTT with AuNRs@RF. Furthermore, Pin1 and IL18-related signaling contributed to the observed perturbation of the NETosis pathway by PPTT with AuNRs@RF. Third, we report a 15-month toxicity study that showed no long-term toxicity of AuNRs in vivo. Together, these data demonstrate that our AuNRs-PPTT platform is effective and safe for cancer therapy in mouse models. These findings provide a strong framework for the translation of PPTT to the clinic.

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