In Vivo Endoscopic Optical Coherence Tomography of Esophagitis, Barrett's Esophagus, and Adenocarcinoma of the Esophagus

Endoscopy ◽  
2000 ◽  
Vol 32 (10) ◽  
pp. 750-755 ◽  
Author(s):  
S. Jäckle ◽  
N. Gladkova ◽  
F. Feldchtein ◽  
A. Terentieva ◽  
B. Brand ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Optical Coherence ◽  
Adenocarcinoma Of The Esophagus ◽  
Endoscopic Optical Coherence Tomography

scholarly journals Assessment of Barrett’s esophagus and dysplasia with ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography

Endoscopy ◽  
2018 ◽  
Vol 51 (04) ◽  
pp. 355-359 ◽  
Author(s):  
Osman Ahsen ◽  
Kaicheng Liang ◽  
Hsiang-Chieh Lee ◽  
Michael Giacomelli ◽  
Zhao Wang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Optical Coherence ◽  
Cross Sectional ◽  
En Face Oct ◽  
En Face ◽  
Treatment Naïve ◽  
History Of

Background This study aimed to evaluate the use of ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography (OCT) with micromotor catheters for the in vivo assessment of Barrett’s esophagus and dysplasia. Methods 74 OCT datasets with correlated biopsy/endoscopic mucosal resection histology (49 nondysplastic Barrett’s esophagus [NDBE], 25 neoplasia) were obtained from 14 patients with Barrett’s esophagus and a history of dysplasia and 30 with NDBE. The associations between irregular mucosal patterns on en face OCT, absence of mucosal layering, surface signal > subsurface, and > 5 atypical glands on cross-sectional OCT vs. histology and treatment history were assessed by three blinded readers. Results Atypical glands under irregular mucosal patterns occurred in 75 % of neoplasia (96 % of treatment-naïve neoplasia) vs. 30 % of NDBE datasets (43 % of short- and 18 % of long-segment NDBE). Mucosal layering was absent in 35 % of neoplasia and 50 % of NDBE datasets, and surface signal > subsurface occurred in 29 % of neoplasia and 30 % of NDBE datasets. Conclusions Atypical glands under irregular mucosal patterns are strongly associated with neoplasia, suggesting potential markers for dysplasia and a role in pathogenesis.

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