Mechanoregulation of stem cell fate via micro-/nano-scale manipulation for regenerative medicine

Nanomedicine ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. 623-638 ◽  
Author(s):  
Chor Yong Tay ◽  
Cheng Gee Koh ◽  
Nguan Soon Tan ◽  
David Tai Leong ◽  
Lay Poh Tan
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Cell Fate ◽  
Stem Cell Fate ◽  
Nano Scale

scholarly journals Orchestrating stem cell fate: Novel tools for regenerative medicine

2019 ◽  
Vol 11 (8) ◽  
pp. 464-475 ◽  
Author(s):  
Sara Cruciani ◽  
Sara Santaniello ◽  
Andrea Montella ◽  
Carlo Ventura ◽  
Margherita Maioli
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Cell Fate ◽  
Stem Cell Fate

scholarly journals Graphene-Based Scaffolds for Regenerative Medicine

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 404
Author(s):  
Pietro Bellet ◽  
Matteo Gasparotto ◽  
Samuel Pressi ◽  
Anna Fortunato ◽  
Giorgia Scapin ◽  
...  
Keyword(s):  
Stem Cell ◽  
Elastic Modulus ◽  
Cell Growth ◽  
Regenerative Medicine ◽  
Cell Fate ◽  
Special Interest ◽  
Leading Edge ◽  
Cell Fate Determination ◽  
Stem Cell Fate ◽  
Cell Lineages

Leading-edge regenerative medicine can take advantage of improved knowledge of key roles played, both in stem cell fate determination and in cell growth/differentiation, by mechano-transduction and other physicochemical stimuli from the tissue environment. This prompted advanced nanomaterials research to provide tissue engineers with next-generation scaffolds consisting of smart nanocomposites and/or hydrogels with nanofillers, where balanced combinations of specific matrices and nanomaterials can mediate and finely tune such stimuli and cues. In this review, we focus on graphene-based nanomaterials as, in addition to modulating nanotopography, elastic modulus and viscoelastic features of the scaffold, they can also regulate its conductivity. This feature is crucial to the determination and differentiation of some cell lineages and is of special interest to neural regenerative medicine. Hereafter we depict relevant properties of such nanofillers, illustrate how problems related to their eventual cytotoxicity are solved via enhanced synthesis, purification and derivatization protocols, and finally provide examples of successful applications in regenerative medicine on a number of tissues.

scholarly journals Nanoscale microenvironment engineering based on layer-by-layer self-assembly to regulate hair follicle stem cell fate for regenerative medicine

Theranostics ◽  
2020 ◽  
Vol 10 (25) ◽  
pp. 11673-11689
Author(s):  
Peng Chen ◽  
Yong Miao ◽  
Feifei Zhang ◽  
Junfei Huang ◽  
Yuxin Chen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Hair Follicle ◽  
Cell Fate ◽  
Self Assembly ◽  
Layer By Layer ◽  
Stem Cell Fate ◽  
Hair Follicle Stem Cell

Chemical and physical properties of regenerative medicine materials controlling stem cell fate

2011 ◽  
Vol 44 (7) ◽  
pp. 635-650 ◽  
Author(s):  
Emilia Kaivosoja ◽  
Gonçalo Barreto ◽  
Kalle Levón ◽  
Sannakaisa Virtanen ◽  
Mari Ainola ◽  
...  
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Physical Properties ◽  
Cell Fate ◽  
Stem Cell Fate

scholarly journals Role of substrate biomechanics in controlling (stem) cell fate: Implications in regenerative medicine

2017 ◽  
Vol 12 (4) ◽  
pp. 1012-1019 ◽  
Author(s):  
Laura Macri‐Pellizzeri ◽  
Elena M. De‐Juan‐Pardo ◽  
Felipe Prosper ◽  
Beatriz Pelacho
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Cell Fate ◽  
Stem Cell Fate
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