Submicron polymer particles containing fluorescent semiconductor nanocrystals CdSe/ZnS for bioassays

Nanomedicine ◽  
2011 ◽  
Vol 6 (2) ◽  
pp. 195-209 ◽  
Author(s):  
Alla N Generalova ◽  
Svetlana V Sizova ◽  
Tatiana A Zdobnova ◽  
Margarita M Zarifullina ◽  
Michail V Artemyev ◽  
...  
Keyword(s):  
Semiconductor Nanocrystals ◽  
Polymer Particles ◽  
Fluorescent Semiconductor Nanocrystals

Fluorescent semiconductor nanocrystals in microscopy and flow cytometry

2011 ◽  
Vol 5 (4) ◽  
pp. 321-331
Author(s):  
I. A. Vorobjev ◽  
E. P. Rafalovskaya-Orlovskaya ◽  
A. A. Gladkih ◽  
D. M. Potashnikova ◽  
N. S. Barteneva
Keyword(s):  
Flow Cytometry ◽  
Semiconductor Nanocrystals ◽  
Fluorescent Semiconductor Nanocrystals

Broadband Up-Conversion at Subsolar Irradiance: Triplet–Triplet Annihilation Boosted by Fluorescent Semiconductor Nanocrystals

Nano Letters ◽  
2014 ◽  
Vol 14 (11) ◽  
pp. 6644-6650 ◽  
Author(s):  
A. Monguzzi ◽  
D. Braga ◽  
M. Gandini ◽  
V. C. Holmberg ◽  
D. K. Kim ◽  
...  
Keyword(s):  
Semiconductor Nanocrystals ◽  
Fluorescent Semiconductor Nanocrystals ◽  
Triplet Triplet Annihilation

Properties of Fluorescent Semiconductor Nanocrystals and their Application to Biological Labeling

2001 ◽  
Vol 2 (4) ◽  
pp. 261-276 ◽  
Author(s):  
Xavier Michalet ◽  
Fabien Pinaud ◽  
Thilo D. Lacoste ◽  
Maxime Dahan ◽  
Marcel P. Bruchez ◽  
...  
Keyword(s):  
Semiconductor Nanocrystals ◽  
Biological Labeling ◽  
Fluorescent Semiconductor Nanocrystals

scholarly journals Biofunctionalized Polyelectrolyte Microcapsules Encoded with Fluorescent Semiconductor Nanocrystals for Highly Specific Targeting and Imaging of Cancer Cells

Photonics ◽  
2019 ◽  
Vol 6 (4) ◽  
pp. 117 ◽  
Author(s):  
Galina Nifontova ◽  
Daria Kalenichenko ◽  
Maria Baryshnikova ◽  
Fernanda Ramos Gomes ◽  
Frauke Alves ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Size Structure ◽  
Semiconductor Nanocrystals ◽  
Transport Processes ◽  
The Body ◽  
Water Soluble ◽  
Fluorescence Signal ◽  
Layer By Layer ◽  
Polyelectrolyte Microcapsules ◽  
Fluorescent Semiconductor Nanocrystals

Fluorescent semiconductor nanocrystals or quantum dots (QDs) are characterized by unique optical properties, including a high photostability, wide absorption spectrum, and narrow, symmetric fluorescence spectrum. This makes them attractive fluorescent nanolabels for the optical encoding of microcarriers intended for targeted drug delivery, diagnosis, and imaging of transport processes on the body, cellular, and subcellular levels. Incorporation of QDs into carriers in the form of polyelectrolyte microcapsules through layer-by-layer adsorption of oppositely charged polyelectrolyte polymers yields microcapsules with a bright fluorescence signal and adaptable size, structure, and surface characteristics without using organic solvents. The easily modifiable surface of the microcapsules allows for its subsequent functionalization with capture molecules, such as antibodies, which ensures specific and selective interaction with cells, including tumor cells, with the use of the bioconjugation technique developed here. We obtained stable water-soluble nanolabels based on QDs whose surface was modified with polyethylene glycol (PEG) derivatives and determined their colloidal and optical characteristics. The obtained nanocrystals were used to encode polyelectrolyte microcapsules optically. The microcapsule surface was modified with humanized monoclonal antibodies (Abs) recognizing a cancer marker, epidermal growth factor receptor (EGFR). The possibility of effective, specific, and selective delivery of the microcapsules to tumor cells expressing EGFR has been demonstrated. The results show that the QD-encoded polyelectrolyte microcapsules functionalized with monoclonal Abs against EGFR can be used for targeted imaging and diagnosis.

Sign in / Sign up

Export Citation Format

Share Document