scholarly journals The clinical role of ‘liquid biopsy’ in hepatocellular carcinoma

2016 ◽  
Vol 3 (1) ◽  
pp. 45-55 ◽  
Author(s):  
Jessica A Howell ◽  
Rohini Sharma
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liquid Biopsy ◽  
Clinical Role

Clinical role of MMP-2/TIMP-2 imbalance in hepatocellular carcinoma

2002 ◽  
Vol 97 (4) ◽  
pp. 425-431 ◽  
Author(s):  
Gianluigi Giannelli ◽  
Carlo Bergamini ◽  
Felice Marinosci ◽  
Emilia Fransvea ◽  
Michele Quaranta ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Role

scholarly journals Liquid Biopsies in Solid Cancers: Implementation in a Nordic Healthcare System

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1861
Author(s):  
Oddmund Nordgård ◽  
Rakel Brendsdal Forthun ◽  
Morten Lapin ◽  
Bjørn Henning Grønberg ◽  
Karl Henning Kalland ◽  
...  
Keyword(s):  
Liquid Biopsy ◽  
Cancer Biology ◽  
Growth Factor Receptor ◽  
Relevant Information ◽  
Circulating Tumor Dna ◽  
Cancer Diagnostics ◽  
Current Evidence ◽  
Liquid Biopsies ◽  
Clinical Role

Liquid biopsies have emerged as a potential new diagnostic tool, providing detailed information relevant for characterization and treatment of solid cancers. We here present an overview of current evidence supporting the clinical relevance of liquid biopsy assessments. We also discuss the implementation of liquid biopsies in clinical studies and their current and future clinical role, with a special reference to the Nordic healthcare systems. Our considerations are restricted to the most established liquid biopsy specimens: circulating tumor DNA (ctDNA) and circulating tumor cells (CTC). Both ctDNA and CTCs have been used for prognostic stratification, treatment choices, and treatment monitoring in solid cancers. Several recent publications also support the role of ctDNA in early cancer detection. ctDNA seems to provide more robust clinically relevant information in general, whereas CTCs have the potential to answer more basic questions related to cancer biology and metastasis. Epidermal growth factor receptor-directed treatment of non-small-cell lung cancer represents a clinical setting where ctDNA already has entered the clinic. The role of liquid biopsies in treatment decisions, standardization of methods, diagnostic performance and the need for further research, as well as cost and regulatory issues were identified as factors that influence further integration in the clinic. In conclusion, substantial evidence supports the clinical utility of liquid biopsies in cancer diagnostics, but further research is still required for a more general application in clinical practice.

scholarly journals Clinical Role of Newly Developed ALBI and mALBI Grades for Treatment of Hepatocellular Carcinoma

2020 ◽  
Vol 10 (20) ◽  
pp. 7178
Author(s):  
Atsushi Hiraoka ◽  
Takashi Kumada
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatic Function ◽  
Tumor Burden ◽  
Clinical Role ◽  
Hepatic Reserve ◽  
Therapeutic Modalities ◽  
Recent Developments ◽  
Detailed Assessment ◽  
Relationship Of

Hepatocellular carcinoma (HCC) is a leading cause of death worldwide. The selection of therapeutic modalities and the prognosis of affected patients are well known to be dependent not only on the tumor burden but also on the hepatic reserve function. Antiviral treatments for chronic hepatitis related to a viral infection and an increase in cases of nonviral HCC associated with the aging of society have resulted in dramatic changes regarding the characteristics of HCC patients. With recent developments in therapeutic modalities for HCC, a more detailed assessment of hepatic function has become an important need. Studies in which the relationship of albumin-bilirubin (ALBI) grade with the prognosis of HCC patients was investigated were reviewed in order to evaluate the usefulness of newly developed ALBI and modified ALBI (mALBI) grades for HCC treatment, as those scoring methods are considered helpful for predicting the prognosis and selecting therapeutic modalities based on the expected prognosis.

Clinical role of serum programmed death ligand 1 in patients with hepatocellular carcinoma: Where does it come from?

Surgery Today ◽  
2019 ◽  
Vol 50 (6) ◽  
pp. 569-576
Author(s):  
Hatem A. Elmezayen ◽  
Hirohisa Okabe ◽  
Yoshifumi Baba ◽  
Toshihiko Yusa ◽  
Rumi Itoyama ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Role ◽  
Programmed Death Ligand 1 ◽  
Programmed Death

scholarly journals The Role of Liquid Biopsy in Hepatocellular Carcinoma Prognostication

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 659 ◽  
Author(s):  
Ismail Labgaa ◽  
Augusto Villanueva ◽  
Olivier Dormond ◽  
Nicolas Demartines ◽  
Emmanuel Melloul
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liquid Biopsy ◽  
Biological Fluids ◽  
Tissue Samples ◽  
Genomic Complexity ◽  
Minimally Invasive Access ◽  
Next Generation Sequencing Ngs ◽  
Generation Sequencing ◽  
Related Mortality

Showing a steadily increasing cancer-related mortality, the epidemiological evolution of hepatocellular carcinoma (HCC) is concerning. Numerous strategies have attempted to prognosticate HCC but their performance is modest; this is partially due to the heterogeneous biology of this cancer. Current clinical guidelines endorse classifications and scores that use clinical variables, such as the Barcelona Clinic Liver Cancer (BCLC) classification. These algorithms are unlikely to fully recapitulate the genomic complexity of HCC. Integrating molecular readouts on a patient-basis, following a precision-medicine perspective, might be an option to refine prognostic systems. The limited access to HCC tissue samples is an important limitation to these approaches but it could be partially circumvented by using liquid biopsy. This concept consists of the molecular analysis of products derived from a solid tumor and released into biological fluids, mostly into the bloodstream. It offers an easy and minimally-invasive access to DNA, RNA, extracellular vesicles and cells that can be analyzed with next-generation sequencing (NGS) technologies. This review aims to investigate the potential contributions of liquid biopsy in HCC prognostication. The results identified prognostic values for each of the components of liquid biopsy, suggesting that this technology may help refine HCC prognostication.

scholarly journals Upregulated expression of MTFR2 as a novel biomarker predicts poor prognosis in hepatocellular carcinoma by bioinformatics analysis

2021 ◽  
Author(s):  
Dan Li ◽  
YanMei Ji ◽  
JiaLong Guo ◽  
Qiang Guo
Keyword(s):  
Hepatocellular Carcinoma ◽  
Poor Prognosis ◽  
Bioinformatics Analysis ◽  
Independent Predictor ◽  
Cancer Stage ◽  
Clinical Role ◽  
P53 Signaling ◽  
Dismal Prognosis ◽  
P53 Signaling Pathway

Aim: The authors investigated the clinical role of MTFR2 in hepatocellular carcinoma (HCC) progression. Results: MTFR2 expression and methylation were abnormal in HCC tissues, and HCC patients with increased MTFR2 expression or methylation had poor or better overall survival, respectively. In addition, increased MTFR2 expression was correlated with age, grade, cancer stage and T stage. MTFR2 was an independent predictor of dismal prognosis in HCC patients. MTFR2 was involved in HCC progression by modulating the cell cycle, homologous recombination, DNA replication, p53 signaling pathway, etc. The ten hub genes were overexpressed in HCC tissues and were linked to cancer stage and dismal prognosis in HCC patients. Conclusion: MTFR2 could be a prospective biomarker of poor prognosis in individuals with HCC.

Expression and Clinical Role of Cdc5L as a Novel Cell Cycle Protein in Hepatocellular Carcinoma

2015 ◽  
Vol 61 (3) ◽  
pp. 795-805 ◽  
Author(s):  
Huiyuan Qiu ◽  
Xiubing Zhang ◽  
Wenkai Ni ◽  
Weidong Shi ◽  
Hui Fan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Cycle ◽  
Cell Cycle Protein ◽  
Clinical Role

scholarly journals Clinical role of tissue and serum levels of SCCA antigen in hepatocellular carcinoma

2005 ◽  
Vol 116 (4) ◽  
pp. 579-583 ◽  
Author(s):  
Gianluigi Giannelli ◽  
Felice Marinosci ◽  
Concetta Sgarra ◽  
Luigi Lupo ◽  
Pietro Dentico ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Serum Levels ◽  
Clinical Role

Comments on expanding the clinical role of psychologists.

1996 ◽  
Vol 51 (3) ◽  
pp. 216-218 ◽  
Author(s):  
Rachel G. Klein
Keyword(s):  
Clinical Role
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