scholarly journals Clinical role of combining alpha‐fetoprotein and lens culinaris agglutinin‐reactive fraction of alpha‐fetoprotein for hepatocellular carcinoma: Evidence from literature and an original study

2020 ◽  
Vol 34 (7) ◽  
Author(s):  
Siyuan Chen ◽  
Junhong Li ◽  
Xiaodan Tan ◽  
Qi Xu ◽  
Yuncong Mo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Lens Culinaris ◽  
Original Study ◽  
Alpha Fetoprotein ◽  
Clinical Role ◽  
Lens Culinaris Agglutinin

Relationship between Lens culinaris agglutinin-reactive alpha-fetoprotein and pathologic features of hepatocellular carcinoma

2005 ◽  
Vol 25 (4) ◽  
pp. 848-853 ◽  
Author(s):  
Toshifumi Tada ◽  
Takashi Kumada ◽  
Hidenori Toyoda ◽  
Seiki Kiriyama ◽  
Yasuhiro Sone ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Lens Culinaris ◽  
Alpha Fetoprotein ◽  
Lens Culinaris Agglutinin ◽  
Pathologic Features

scholarly journals Diagnostic value of alpha-fetoprotein, Lens culinaris agglutinin-reactive alpha-fetoprotein, and des-gamma-carboxyprothrombin in hepatitis B virus-related hepatocellular carcinoma

2019 ◽  
Vol 48 (3) ◽  
pp. 030006051988927
Author(s):  
Ting Song ◽  
Lili Wang ◽  
Bin Su ◽  
Weiping Zeng ◽  
Taiyi Jiang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Sensitivity And Specificity ◽  
Lens Culinaris ◽  
Diagnostic Value ◽  
Alpha Fetoprotein ◽  
Lens Culinaris Agglutinin ◽  
B Virus ◽  
Early Hcc

Objective This study aimed to explore the use of different combinations of alpha-fetoprotein (AFP), Lens culinaris agglutinin-reactive AFP (AFP-L3), and des-gamma-carboxyprothrombin (DCP) for the early diagnosis of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV)-associated liver cirrhosis (LC). Methods There were 167 subjects, including 100 with HCC and 67 with LC, who were enrolled into this study. Serum AFP, AFP-L3, and DCP levels were detected by chemiluminescent enzyme immunoassay and analyzed using the receiver operating characteristics (ROC) method. Results The sensitivity and specificity of AFP and DCP for differentiating between early HCC and HBV-associated LC were 51.5% and 92.5%, and 60.0% and 84.7%, respectively. Comparative analysis of ROC curves showed no significant difference in the area under the curve (AUC) for AFP and DCP. Moreover, the combination of AFP and DCP showed the largest AUC value with a diagnostic sensitivity and specificity of 67% and 83.1%, respectively. Conclusion These results suggest that AFP is the best single biomarker for distinguishing between HBV-associated LC and early HCC induced by HBV. However, the combination of AFP and DCP can enhance the diagnostic value of AFP for differentiating between these diseases.

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