Risk factors for survival after lung metastasectomy in colorectal cancer patients: systematic review and meta-analysis

2015 ◽  
Vol 11 (2s) ◽  
pp. 31-33 ◽  
Author(s):  
Michel Gonzalez ◽  
Pascal Gervaz
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Systematic Review ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Lung Metastasectomy ◽  
Colorectal Cancer Patients ◽  
Risk Factors For Survival

Risk Factors for Survival after Lung Metastasectomy in Colorectal Cancer Patients: A Systematic Review and Meta-Analysis

2012 ◽  
Vol 20 (2) ◽  
pp. 572-579 ◽  
Author(s):  
Michel Gonzalez ◽  
Antoine Poncet ◽  
Christophe Combescure ◽  
John Robert ◽  
Hans Beat Ris ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Systematic Review ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Lung Metastasectomy ◽  
Colorectal Cancer Patients ◽  
Risk Factors For Survival

scholarly journals KRAS and BRAF Mutations as survival prognostic factors for Metastatic Colorectal Cancer patients after Lung metastasectomy: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Iraj Shahramian ◽  
Fateme Parooie ◽  
morteza salarzaei
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Cancer Patients ◽  
Kras Mutation ◽  
Meta Analysis ◽  
Kras Mutations ◽  
Female Ratio ◽  
Lung Metastasectomy ◽  
Colorectal Cancer Patients ◽  
Male To Female

Abstract Introduction While knowledge has grown extensively regarding the impact of mutations on colorectal cancer prognosis, their role in outcomes after pulmonary metastasectomy (PM) remains minimally understood. Therefore, in this paper, we conduct a systematic review and meta-analysis of retrospective and prospective studies to evaluate whether KRAS or BRAF mutation status can be independent predictors in colorectal cancer patients undergoing complete lung metastasis surgery.Methods A systematic literature review was performed to identify articles reporting overall survival (OS) of patients who underwent lung metastasectomy for colorectal cancer lung metastases (CRLM), stratified according to KRAS and BRAF mutational status. Hazard ratios (HRs) from multivariate analyses were pooled in the meta-analysis.Results 9 studies, including 1833 patients, were eligible for the meta-analysis. Based on the random effect model, the total frequency of KRAS mutations in 1305 patients who had undergone the lung metastasectomy was 45% and the total 5-year OS in these patients was 55.7%. five of them reported OS stratified according to KRAS mutation. The pooled analysis revealed that KRAS mutation was negatively associated with OS (HR, 1.674; 95% confidence interval [CI], 1.341-2.089; P < .001). the rate of KRAS mutations were lower in the studies with higher male to female ratio. There was statistically significant linear trend in univariate meta-regression to explain effect size variation by male to female ratio of study with coefficient = 0.47 (95% CI 0.03, 0.91), P = 0.03. disease free survival (DFS), thoracic metastases and origin of primary tumor were significantly influenced by KRAS mutation status.Conclusions Our meta-analysis confirms the KRAS mutation as a strong and predictive biomarker which makes overall survival lower in patients with colorectal cancer undergoing pulmonary metastasis surgery. Certainly, this interesting evidence represents the first step towards a deeper understanding of the molecular mechanisms underlying tumor behavior and patient outcomes in a subgroup of clinically selected colorectal cancer patients. By considering tumor molecular characteristics and other clinical-pathological factors, our results confirm the use of new therapeutic models to predict outcomes of patients undergoing colorectal lung metastasis surgery and to isolate both systemic and loco-regional treatment strategies.

Impact of comorbidity and frailty on prognosis in colorectal cancer patients: A systematic review and meta-analysis

2018 ◽  
Vol 64 ◽  
pp. 30-39 ◽  
Author(s):  
Daniel Boakye ◽  
Bettina Rillmann ◽  
Viola Walter ◽  
Lina Jansen ◽  
Michael Hoffmeister ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Colorectal Cancer Patients

scholarly journals The Risk and Prevalence of COVID-19 Infection in Colorectal Cancer Patients: a Systematic Review and Meta-analysis

2020 ◽  
Author(s):  
Mohammad Hossein Antikchi ◽  
Hossein Neamatzadeh ◽  
Yaser Ghelmani ◽  
Jamal Jafari-Nedooshan ◽  
Seyed Alireza Dastgheib ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Colorectal Cancer Patients

scholarly journals Statin uses and mortality in colorectal cancer patients: An updated systematic review and meta‐analysis

2019 ◽  
Vol 8 (6) ◽  
pp. 3305-3313 ◽  
Author(s):  
Yue Li ◽  
Xingkang He ◽  
Yu’e Ding ◽  
Hongyang Chen ◽  
Leimin Sun
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Colorectal Cancer Patients

scholarly journals Prevalence of RAS and BRAF mutations in metastatic colorectal cancer patients by tumor sidedness: A systematic review and meta‐analysis

2019 ◽  
Vol 9 (3) ◽  
pp. 1044-1057 ◽  
Author(s):  
Lauren C. Bylsma ◽  
Christina Gillezeau ◽  
Tamer A. Garawin ◽  
Michael A. Kelsh ◽  
Jon P. Fryzek ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Braf Mutations ◽  
Colorectal Cancer Patients
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