scholarly journals Prevalence of RAS and BRAF mutations in metastatic colorectal cancer patients by tumor sidedness: A systematic review and meta‐analysis

2019 ◽  
Vol 9 (3) ◽  
pp. 1044-1057 ◽  
Author(s):  
Lauren C. Bylsma ◽  
Christina Gillezeau ◽  
Tamer A. Garawin ◽  
Michael A. Kelsh ◽  
Jon P. Fryzek ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Braf Mutations ◽  
Colorectal Cancer Patients

Effect of KRAS and BRAF mutations in metastatic colorectal cancer patients: A systematic review and meta-analysis based on tumor sidedness and KRAS subtypes

2021 ◽  
pp. 1-10
Author(s):  
Khadijeh Saravani ◽  
Morteza Salarzaei ◽  
Fateme Parooie
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Braf Mutation ◽  
Meta Analysis ◽  
Tumor Location ◽  
Cochrane Library ◽  
Braf Mutations ◽  
The Right ◽  
Colorectal Cancer Patients

INTRODUCTION: Metastatic or recurrent colorectal cancer (MRCRC) has a poor prognosis. The aim of the present meta-analysis was to assess the prevalence of different subtypes of KRAS mutation and BRAF mutation in metastatic CRC patients, and evaluate the relationship between the tumor sidedness and prevalence of KRAS and BRAF mutation. METHODS: We searched MEDLINE/PubMed, the Cochrane Library, and ClinicalTrials.gov from January 2010 to July 2020. The data were extracted independently according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The statistical analysis was done using STATA and Meta-Disk 1.4 applications. RESULTS: Overall, 6699 colorectal cancer patients were included. KRAS and BRAF mutation was reported in 28% and 6% of patients, respectively. The overall prevalence of right primary and left primary metastatic CRC patients with mutated KRAS was 40% and 60%. However, the prevalence BRAF mutated right primary and left primary metastatic CRC patients was 37% and 63%. The overall HR was 2.38 for patients with metastatic CRC who had a mutated type of KRAS. Our study showed a mean overall survival of 35.4 month for KRAS mutant and a 10.12 month survival for BRAF mutant patients with metastatic colorectal cancer patients. CONCLUSION: The prevalence of KRAS and BRAF mutations varied significantly according to the location of the tumor. BRAF mutations are more commonly found in metastatic colorectal cancers on the right side. Liver was the most common site of metastases in patients with mutant KRAS and the mortality of patients with mutant KRAS was 2.3 times higher than the patients with wild types. These results help to better describe the population of mCRC patients and can have implications for improving and organizing anti-EGFR therapies. Further research is needed to assess differences in survival through mutation status and primary tumor location.

Impact of comorbidity and frailty on prognosis in colorectal cancer patients: A systematic review and meta-analysis

2018 ◽  
Vol 64 ◽  
pp. 30-39 ◽  
Author(s):  
Daniel Boakye ◽  
Bettina Rillmann ◽  
Viola Walter ◽  
Lina Jansen ◽  
Michael Hoffmeister ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Colorectal Cancer Patients

scholarly journals The Risk and Prevalence of COVID-19 Infection in Colorectal Cancer Patients: a Systematic Review and Meta-analysis

2020 ◽  
Author(s):  
Mohammad Hossein Antikchi ◽  
Hossein Neamatzadeh ◽  
Yaser Ghelmani ◽  
Jamal Jafari-Nedooshan ◽  
Seyed Alireza Dastgheib ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Colorectal Cancer Patients

scholarly journals Statin uses and mortality in colorectal cancer patients: An updated systematic review and meta‐analysis

2019 ◽  
Vol 8 (6) ◽  
pp. 3305-3313 ◽  
Author(s):  
Yue Li ◽  
Xingkang He ◽  
Yu’e Ding ◽  
Hongyang Chen ◽  
Leimin Sun
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Colorectal Cancer Patients
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