scholarly journals Epigenetics of early-life lead exposure and effects on brain development

Epigenomics ◽  
2012 ◽  
Vol 4 (6) ◽  
pp. 665-674 ◽  
Author(s):  
Marie-Claude Senut ◽  
Pablo Cingolani ◽  
Arko Sen ◽  
Adele Kruger ◽  
Asra Shaik ◽  
...  
Keyword(s):  
Brain Development ◽  
Lead Exposure ◽  
Early Life

No delayed behavioral and phenotypic responses to experimental early-life lead exposure in great tits (Parus major)

2014 ◽  
Vol 22 (4) ◽  
pp. 2610-2621 ◽  
Author(s):  
Suvi Ruuskanen ◽  
Tapio Eeva ◽  
Päivi Kotitalo ◽  
Janina Stauffer ◽  
Miia Rainio
Keyword(s):  
Lead Exposure ◽  
Early Life ◽  
Parus Major ◽  
Phenotypic Responses

scholarly journals Size at birth, lifecourse factors, and cognitive function in late life: findings from the MYsore study of Natal effects on Ageing and Health (MYNAH) cohort in South India

2021 ◽  
pp. 1-14
Author(s):  
Murali Krishna ◽  
Ghattu V. Krishnaveni ◽  
Veena Sargur ◽  
Kalyanaraman Kumaran ◽  
Mohan Kumar ◽  
...  
Keyword(s):  
Birth Weight ◽  
Cognitive Function ◽  
Brain Development ◽  
Educational Level ◽  
Early Life ◽  
South India ◽  
Late Life ◽  
Positive Effects ◽  
Cardiometabolic Disorders ◽  
Size At Birth

ABSTRACT Objective: To examine if smaller size at birth, an indicator of growth restriction in utero, is associated with lower cognition in late life, and whether this may be mediated by impaired early life brain development and/or adverse cardiometabolic programming. Design: Longitudinal follow-up of a birth cohort. Setting: CSI Holdsworth Memorial Hospital (HMH), Mysore South India. Participants: 721 men and women (55–80 years) whose size at birth was recorded at HMH. Approximately 20 years earlier, a subset (n = 522) of them had assessments for cardiometabolic disorders in mid-life. Measurements: Standardized measurement of cognitive function, depression, sociodemographic, and lifestyle factors; blood tests and assessments for cardiometabolic disorders Results: Participants who were heavier at birth had higher composite cognitive scores (0.12 SD per SD birth weight [95% CI 0.05, 0.19] p = 0.001) in late life. Other lifecourse factors independently positively related to cognition were maternal educational level and participants’ own educational level, adult leg length, body mass index, and socioeconomic position, and negatively were diabetes in mid-life and current depression and stroke. The association of birth weight with cognition was independent cardiometabolic risk factors and was attenuated after adjustment for all lifecourse factors (0.08 SD per SD birth weight [95% CI −0.01, 0.18] p = 0.07). Conclusions: The findings are consistent with positive effects of early life environmental factors (better fetal growth, education, and childhood socioeconomic status) on brain development resulting in greater long-term cognitive function. The results do not support a pathway linking poorer fetal development with reduced late life cognitive function through cardiometabolic programming.

Targeting the gut microbiota to influence brain development and function in early life

2018 ◽  
Vol 95 ◽  
pp. 191-201 ◽  
Author(s):  
Shugui Wang ◽  
Louise Harvey ◽  
Rocio Martin ◽  
Eline M. van der Beek ◽  
Jan Knol ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Brain Development ◽  
Early Life ◽  
And Function

Nutrition and Brain Development in Early Life

2015 ◽  
pp. 79-126
Author(s):  
Elizabeth Prado ◽  
Kathryn Dewey
Keyword(s):  
Brain Development ◽  
Early Life

Early life predictors of brain development at term-equivalent age in infants born across the gestational age spectrum

NeuroImage ◽  
2019 ◽  
Vol 185 ◽  
pp. 813-824 ◽  
Author(s):  
Deanne K. Thompson ◽  
Claire E. Kelly ◽  
Jian Chen ◽  
Richard Beare ◽  
Bonnie Alexander ◽  
...  
Keyword(s):  
Brain Development ◽  
Gestational Age ◽  
Early Life ◽  
Equivalent Age

Effects of chronic low level lead exposure on brain development and function

1982 ◽  
Vol 5 ◽  
pp. 207-209 ◽  
Author(s):  
Christopher Winder ◽  
Neil G. Carmichael ◽  
Paul D. Lewis
Keyword(s):  
Brain Development ◽  
Lead Exposure ◽  
Low Level ◽  
And Function
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