Mycosis fungoides and other cutaneous T-cell lymphomas

2013 ◽  
pp. 264-282
Author(s):  
Dario Tomasini ◽  
Marco Lucioni ◽  
Marco Paulli ◽  
Emilio Berti
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
T Cell Lymphomas

scholarly journals Expression and activity of IL-17 in cutaneous T-cell lymphomas(mycosis fungoides and sezary syndrome)

2004 ◽  
Vol 112 (1) ◽  
pp. 113-120 ◽  
Author(s):  
Arnaud Cirée ◽  
Laurence Michel ◽  
Sophie Camilleri-Bröet ◽  
Francette Jean Louis ◽  
Michèle Oster ◽  
...  
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
T Cell Lymphomas ◽  
Expression And Activity

scholarly journals Non–Mycosis Fungoides Cutaneous T-Cell Lymphomas

2013 ◽  
Vol 139 (4) ◽  
pp. 491-514 ◽  
Author(s):  
Leticia Quintanilla-Martinez ◽  
Patty M. Jansen ◽  
Marsha C. Kinney ◽  
Steven H. Swerdlow ◽  
Rein Willemze
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
T Cell Lymphomas

IL-15 and IL-16 overexpression in cutaneous T-cell lymphomas: stage-dependent increase in mycosis fungoides progression

2000 ◽  
Vol 9 (4) ◽  
pp. 248-251 ◽  
Author(s):  
K. Asadullah ◽  
A. Haeussler-Quade ◽  
S. Gellrich ◽  
S. Hanneken ◽  
T. E. Hansen-Hagge ◽  
...  
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
T Cell Lymphomas

scholarly journals The expression of CD26 and CD40 ligand is mutually exclusive in human T- cell non-Hodgkin's lymphomas/leukemias

Blood ◽  
1995 ◽  
Vol 86 (12) ◽  
pp. 4617-4626 ◽  
Author(s):  
A Carbone ◽  
A Gloghini ◽  
V Zagonel ◽  
D Aldinucci ◽  
V Gattei ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Lymphocytes ◽  
Mycosis Fungoides ◽  
Cell Lines ◽  
Critical Role ◽  
Cd40 Ligand ◽  
T Cell Lymphomas ◽  
Human T Cell ◽  
Hodgkin's Lymphomas

CD26 and CD40 ligand (CD40L) are surface molecules on human activated T lymphocytes that play a critical role in the regulation of lymphopoiesis. Both molecules are expressed on a restricted fraction of human T-cell non-Hodgkin's lymphomas (NHL)/leukemias; however, little is known about their functional and/or clinical significance in these disorders. In this study, the pattern of expression of CD40L was compared with that of the CD26 molecule. A series of 67 human T-cell NHL/leukemias and a panel of leukemia/lymphoma T-cell lines were evaluated by immunohistochemistry, flow cytometry, and RNA studies. The overall frequency of CD26+ and CD40L+ samples was rather similar (25/67 [37%] v 18/67 [27%]). However, the majority of CD26-expressing cases clustered in the lymphoblastic lymphomas (LBL)/T-acute lymphoblastic leukemias (ALL; 12/23) and CD30+ anaplastic large-cell (ALC) lymphomas (5/8), whereas CD40L+ lymphomas included a large fraction of mycosis fungoides (11/21 [52%]). CD26 and CD40L coexpression was found only in 2 myocosis fungoides cases and 1 small lymphocytic lymphoma. Thus, the expression of the two antigens was mutually exclusive in almost all T- cell lymphomas/leukemias. Accordingly, lymphoma cell lines expressed either one of the molecules or the relative amounts of CD26 and CD40L were inversely proportional. In contrast, reactive T lymphocytes from patients with non-neoplastic T-cell expansions and in vitro activated CD3+ or CD4+ normal T cells were found to coexpress CD40L and CD26. Results of a multivariate analysis showed that the expression of CD26 in T-cell LBL/ALL patients was associated to a worse outcome in terms of survival, as compared with patients with CD26- tumors (P < or = .0001). Based on our results, it can be concluded that, (1) as opposed to activated or reactive normal T cells, the expression of CD26 and of CD40L is mutually exclusive in human T-cell lymphomas/leukemias; (2) expression of CD26 is restricted to aggressive pathologic entities, such as T-cell LBL/ALL and T-cell CD30+ ALC lymphomas, whereas CD40L is expressed on slow progressing diseases such as mycosis fungoides; and (3) within the T-cell LBL/ALL group of tumors, CD26 may identify a subset of poor prognosis patients.

scholarly journals An overview of cutaneous T cell lymphomas

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 1882 ◽  
Author(s):  
Nooshin Bagherani ◽  
Bruce R. Smoller
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
Mycosis Fungoides ◽  
Annual Incidence ◽  
Heterogeneous Group ◽  
Not Otherwise Specified ◽  
T Cell Lymphomas ◽  
Hodgkin's Lymphomas ◽  
Diagnosis Therapy ◽  
Peripheral T Cell Lymphomas

Cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of extranodal non-Hodgkin’s lymphomas that are characterized by a cutaneous infiltration of malignant monoclonal T lymphocytes. They typically afflict adults with a median age of 55 to 60 years, and the annual incidence is about 0.5 per 100,000. Mycosis fungoides, Sézary syndrome, and primary cutaneous peripheral T cell lymphomas not otherwise specified are the most important subtypes of CTCL. CTCL is a complicated concept in terms of etiopathogenesis, diagnosis, therapy, and prognosis. Herein, we summarize advances which have been achieved in these fields.

scholarly journals Quantifying Skin Disease Burden in Mycosis Fungoides–Type Cutaneous T-Cell Lymphomas

2002 ◽  
Vol 138 (1) ◽  
Author(s):  
Seth R. Stevens ◽  
Malcolm S. Ke ◽  
Eileen J. Parry ◽  
Julie Mark ◽  
Kevin D. Cooper
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
Skin Disease ◽  
Disease Burden ◽  
T Cell Lymphomas
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