scholarly journals Expression and activity of IL-17 in cutaneous T-cell lymphomas(mycosis fungoides and sezary syndrome)

2004 ◽  
Vol 112 (1) ◽  
pp. 113-120 ◽  
Author(s):  
Arnaud Cirée ◽  
Laurence Michel ◽  
Sophie Camilleri-Bröet ◽  
Francette Jean Louis ◽  
Michèle Oster ◽  
...  
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
T Cell Lymphomas ◽  
Expression And Activity

scholarly journals Mycosis Fungoides and Sézary Syndrome: An Integrative Review of the Pathophysiology, Molecular Drivers, and Targeted Therapy

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1931
Author(s):  
Nuria García-Díaz ◽  
Miguel Ángel Piris ◽  
Pablo Luis Ortiz‐Romero ◽  
José Pedro Vaqué
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
T Cell Receptor ◽  
Molecular Mechanisms ◽  
Cell Receptor ◽  
Janus Kinase ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Signal Transducer ◽  
T Cell Lymphomas

Primary cutaneous T-cell lymphomas (CTCLs) constitute a heterogeneous group of diseases that affect the skin. Mycosis fungoides (MF) and Sézary syndrome (SS) account for the majority of these lesions and have recently been the focus of extensive translational research. This review describes and discusses the main pathobiological manifestations of MF/SS, the molecular and clinical features currently used for diagnosis and staging, and the different therapies already approved or under development. Furthermore, we highlight and discuss the main findings illuminating key molecular mechanisms that can act as drivers for the development and progression of MF/SS. These seem to make up an orchestrated constellation of genomic and environmental alterations generated around deregulated T-cell receptor (TCR)/phospholipase C, gamma 1, (PLCG1) and Janus kinase/ signal transducer and activator of transcription (JAK/STAT) activities that do indeed provide us with novel opportunities for diagnosis and therapy.

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