mAbs targeting CD20 and other lymphocyte CD markers in lymphoma treatment

2013 ◽  
pp. 6-19
Author(s):  
Letizia Polito ◽  
Rossella Mancuso ◽  
Daniele Mercatelli ◽  
Massimo Bortolotti ◽  
Andrea Bolognesi
Keyword(s):  
Lymphoma Treatment ◽  
Cd Markers

Expression of CD markers on PBMC after cultivation

1997 ◽  
Vol 56 (1-3) ◽  
pp. 51
Author(s):  
J Bártová
Keyword(s):  
Cd Markers

Aberrant Expression of CD Markers in Acute Myeloid Leukaemia

2018 ◽  
Vol 2 (01) ◽  
pp. 14-16
Author(s):  
Abul Kalam Azad ◽  
Md. Rafiquzzaman Khan ◽  
ABM Hasan Habib ◽  
Md. Abdul Wadud Miah ◽  
Masuda Begum
Keyword(s):  
Flow Cytometry ◽  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Acute Leukaemia ◽  
Antigen Expression ◽  
Aberrant Expression ◽  
Female Ratio ◽  
Cd Antigen ◽  
Cd Markers ◽  
Acute Myeloid

Background: Aberrant expression of cluster differentiation (CD) antigen marker is associated with poor outcome of acute leukaemia. Objective: Aim of this study is to determine the frequency and pattern of aberrant expression of CD markers in acute myeloid leukaemia patients in Bangladesh. Methods: This retrospective data analysis was conducted in the Department of Haematology, Bangabandhu Sheikh Mujib Medical University (BSMMU) to assess the frequency of aberrant CD antigen expression in acute myeloid leukaemia from October 2016 to September 2017. During this period, we did one hundred flow cytometry of acute leukaemia patients and among them we found 48 acute myeloid Leukaemia (AML) who were included in this study. Result: Mean age of patients was 35 years (SD­ +14 years; Rang 3 to 50 years) with male: female ratio of 0.92. Four colour flow cytometry was done on fresh bone marrow aspirates and peripheral blood. Among 48 AML patients, aberrant CD expression was observed in 58% cases.  CD5 and cCD79a lymphoid markers were seen to be expressed in 32% cases of AML. Aberrant cCD3 and CD7 were expressed in 29% and 25% cases respectively and aberrant CD10, CD19, cCD22 were expressed in 11%, 3%, 3% cases acute myeloid leukaemia patients respectively. Conclusion: Aberrant CD antigen expression is not uncommon in AML patients of Bangladeshi population that may adversely affect the treatment outcome of the disease.

scholarly journals Antibody-drug conjugates for the treatment of lymphoma: clinical advances and latest progress

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Yurou Chu ◽  
Xiangxiang Zhou ◽  
Xin Wang
Keyword(s):  
Therapeutic Index ◽  
Essential Elements ◽  
Brentuximab Vedotin ◽  
Efficacy And Safety ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Lymphoma Treatment ◽  
Novel Targets ◽  
Clinical Advances ◽  
Antibody Drug

AbstractAntibody-drug conjugates (ADCs) are a promising class of immunotherapies with the potential to specifically target tumor cells and ameliorate the therapeutic index of cytotoxic drugs. ADCs comprise monoclonal antibodies, cytotoxic payloads with inherent antitumor activity, and specialized linkers connecting the two. In recent years, three ADCs, brentuximab vedotin, polatuzumab vedotin, and loncastuximab tesirine, have been approved and are already establishing their place in lymphoma treatment. As the efficacy and safety of ADCs have moved in synchrony with advances in their design, a plethora of novel ADCs have garnered growing interest as treatments. In this review, we provide an overview of the essential elements of ADC strategies in lymphoma and elucidate the up-to-date progress, current challenges, and novel targets of ADCs in this rapidly evolving field.

Primary leptomeningeal lymphoma masquerading as infectious tubercular meningitis

2021 ◽  
Vol 14 (9) ◽  
pp. e243574
Author(s):  
Salini Sumangala ◽  
Thidar Htwe ◽  
Yousuf Ansari ◽  
Lidia Martinez- Alvarez
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Correct Diagnosis ◽  
Central Nervous System Lymphoma ◽  
Final Diagnosis ◽  
Csf Analysis ◽  
Antitubercular Treatment ◽  
Lymphoma Treatment ◽  
Work Up ◽  
Timely Treatment

Primary central nervous system lymphoma (PCNSL) is infrequent and often poses diagnostic conundrums due to its protean manifestations. We present the case of a South Asian young man presenting with raised intracranial pressure and a lymphocytic cerebrospinal fluid (CSF) with pronounced hypoglycorrhachia. Progression of the neuro-ophthalmic signs while on early stages of antitubercular treatment led to additional investigations that produced a final diagnosis of primary leptomeningeal lymphoma. Treatment with chemoimmunotherapy (methotrexate, cytarabine, thiotepa and rituximab (MATRix)) achieved full radiological remission followed by successful autologous transplant. This case highlights the difficulties and diagnostic dilemmas when PCNSL presents as a chronic meningeal infiltrative process. While contextually this CSF is most often indicative of central nervous system tuberculosis and justifies empirical treatment initiation alone, it is essential to include differential diagnoses in the investigation work-up, which also carry poor prognosis without timely treatment. High suspicion, multidisciplinary collaboration and appropriate CSF analysis were the key for a correct diagnosis.

scholarly journals Relapsed and refractory primary CNS lymphoma: treatment approaches in routine practice

2021 ◽  
Vol 0 ◽  
pp. 0-0
Author(s):  
Prakash Ambady ◽  
Nancy D. Doolittle ◽  
Christopher P. Fox
Keyword(s):  
Primary Cns Lymphoma ◽  
Cns Lymphoma ◽  
Routine Practice ◽  
Treatment Approaches ◽  
Lymphoma Treatment

scholarly journals Retrospective Evaluation of Primary Mediastinal Large B Cell Lymphoma Treatment Results

LLM Dergi ◽  
2018 ◽  
Vol 2 (3) ◽  
pp. 60-64
Author(s):  
Erden ATİLLA ◽  
Pınar ATACA ATİLLA ◽  
Güldane CENGİZ SEVAL ◽  
Selami Koçak TOPRAK ◽  
Osman İLHAN ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Retrospective Evaluation ◽  
Treatment Results ◽  
Large B Cell Lymphoma ◽  
Lymphoma Treatment ◽  
Large B Cell

scholarly journals Frequency of HLA Antigens in a Sample of Iraqi Brucellosis Patients

2012 ◽  
Vol 9 (1) ◽  
pp. 86-92
Author(s):  
Baghdad Science Journal
Keyword(s):  
Hla Antigens ◽  
Healthy Controls ◽  
Cd Markers

Fifty one patients with serologically confirmed brucellosis and 70 healthy controls were phenotyped for HLA-A, -B, -DR and -DQ antigens by using standard microlympho-cytotoxicity method, and lymphocytes defined by their CD markers (CD3, CD4, CD8 and CD19). The results revealed a significant (Pc = 0.001) increased frequency of HLA-DR8 (41.18 vs. 10.0%) in the patients . A significant increased percentage of CD8+ lymphocytes was also increased in the patients (25.15 vs. 22.0%; P = 0.006), while CD3+ lymphocytes were significantly decreased (75.1 vs. 79.4%; P = 0.02).

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