Oil emulsions as vaccine adjuvants

2011 ◽  
pp. 28-40 ◽  
Author(s):  
Jean Haensler
Keyword(s):  
Vaccine Adjuvants ◽  
Oil Emulsions

Nanodiamonds in Oil Emulsions as Effective Vaccine Adjuvants and Antitumor Therapeutic Agents

2021 ◽  
Author(s):  
Hsin-Hung Lin ◽  
Chih-Yen Wang ◽  
Feng-Jen Hsieh ◽  
Fang-Zhen Liao ◽  
Yu-Kai Su ◽  
...  
Keyword(s):  
Antibody Production ◽  
High Efficiency ◽  
Effective Vaccine ◽  
Vaccine Adjuvants ◽  
Immunological Responses ◽  
Freund’S Adjuvant ◽  
Freund's Adjuvant ◽  
Oil Emulsions ◽  
New Formulation ◽  
Therapeutic Activities

Abstract Background Vaccination is an effective tool to elicit immunological responses that mediate the protection from infection or disease. Composed of mineral oil and mycobacteria pathogens, complete Freund’s adjuvant (CFA) is one of the most commonly employed adjuvants for antibody production and vaccination due to its high efficiency. However, the dead mycobacteria in CFA can cause many allergic reactions. To avoid these adverse effects, we propose here a new formulation based on the use of nanodiamonds (NDs) as biocompatible non-allergic additives in incomplete Freund’s adjuvant (IFA) instead. ResultsTested with chicken egg ovalbumin (OVA) in mouse models, the new formulation with 100-nm NDs was found to serve well as a safe and potent vaccine adjuvant that significantly enhanced the immune responses and reduced the consumption of antigens in producing the antibodies of interest. Additionally, the composites showed distinct therapeutic activities, as proven by the OVA/ND/IFA treatment which effectively inhibited the tumor progression of OVA-expressing E.G7 cells inoculated in mice and allowed the animals to survive up to 35 days post tumor-cell challenges. ConclusionsThe dual functionality of ND/IFA makes it useful as adjuvants not only to increase antibody production but also to create single-dose vaccines.

Problems of formation and separation of abnormally stable oil emulsions at oil treatment facilities

2019 ◽  
Vol 07 ◽  
pp. 6-9
Author(s):  
E.P. Trofimova ◽  
◽  
E.S. Sorokina ◽  
K.H. Pappel ◽  
◽  
...  
Keyword(s):  
Treatment Facilities ◽  
Oil Emulsions

Development of technologies for breaking stable water-in-oil emulsions stabilized by solids

2019 ◽  
pp. 52-54
Author(s):  
E.I. Akhmetshina ◽  
◽  
R.Z. Sakhabutdinov ◽  
F.R. Gubaidulin ◽  
A.N. Sudykin ◽  
...  
Keyword(s):  
Oil Emulsions

Rheology of Cyclopentane Hydrates formed in Water-in-model Oil Emulsions

2020 ◽  
Author(s):  
Marcio Ozorio ◽  
Gustavo Alonso Barrientos Sandoval ◽  
Monica Naccache ◽  
Paulo Roberto de Souza Mendes ◽  
Adriana Teixeira ◽  
...  
Keyword(s):  
Oil Emulsions ◽  
Model Oil

Formation, Stability and Properties of Hemp Seed Oil Emulsions for Application in the Cosmetics Industry

2020 ◽  
Vol 57 (6) ◽  
pp. 451-459
Author(s):  
Liujun Pei ◽  
Yuni Luo ◽  
Xiaomin Gu ◽  
Jiping Wang
Keyword(s):  
Seed Oil ◽  
Hemp Seed ◽  
Oil Emulsions

Destruction of water-in-oil emulsions in electromagnetic fields in a dynamic mode

2012 ◽  
Vol 9 (1) ◽  
pp. 110-115
Author(s):  
L.A. Kovaleva ◽  
R.R. Zinnatullin ◽  
V.N. Blagochinnov ◽  
A.A. Musin ◽  
Yu.I. Fatkhullina ◽  
...  
Keyword(s):  
Dielectric Properties ◽  
Radio Frequency ◽  
Electromagnetic Fields ◽  
Dynamic Mode ◽  
Droplet Dynamics ◽  
Oil Emulsion ◽  
Numerical Studies ◽  
Em Field ◽  
Oil Emulsions ◽  
Water In Oil Emulsion

Some results of experimental and numerical studies of the influence of radio-frequency (RF) and microwave (MW) electromagnetic (EM) fields on water-in-oil emulsions are presented. A detailed investigation of the dependence of the dielectric properties of emulsions on the frequency of the field makes it possible to establish the most effective frequency range of the EM influence. The results of water-in-oil emulsion stability in the RF EM field depending on their dielectric properties are presented. The effect of the MW EM field on the emulsion in a dynamic mode has been studied experimentally. In an attempt to understand the mechanism of emulsion destruction the mathematical model for a single emulsion droplet dynamics in radio-frequency (RF) and microwave (MW) electromagnetic fields is formulated.

Enzyme-Instructed Self-assembly in Biological Milieu for Theranostics Purpose

2019 ◽  
Vol 26 (8) ◽  
pp. 1351-1365 ◽  
Author(s):  
Zhentao Huang ◽  
Qingxin Yao ◽  
Simin Wei ◽  
Jiali Chen ◽  
Yuan Gao
Keyword(s):  
Small Molecules ◽  
Precision Medicine ◽  
Self Assembly ◽  
Public Healthcare ◽  
Enzymatic Conversion ◽  
Vaccine Adjuvants ◽  
New Paradigm ◽  
Cancer Treatments ◽  
The Past ◽  
Biological Milieu

Precision medicine is in an urgent need for public healthcare. Among the past several decades, the flourishing development in nanotechnology significantly advances the realization of precision nanomedicine. Comparing to well-documented nanoparticlebased strategy, in this review, we focus on the strategy using enzyme instructed selfassembly (EISA) in biological milieu for theranostics purpose. In principle, the design of small molecules for EISA requires two aspects: (1) the substrate of enzyme of interest; and (2) self-assembly potency after enzymatic conversion. This strategy has shown its irreplaceable advantages in nanomedicne, specifically for cancer treatments and Vaccine Adjuvants. Interestingly, all the reported examples rely on only one kind of enzymehydrolase. Therefore, we envision that the application of EISA strategy just begins and will lead to a new paradigm in nanomedicine.

Demulsification of a Water-in-crude Oil Emulsion with a Corn Oil BasedDemulsifier using the Response Surface Methodology: Modelling and Optimization

2021 ◽  
Vol 14 ◽  
Author(s):  
Abed Saad ◽  
Nour Abdurahman ◽  
Rosli Mohd Yunus
Keyword(s):  
Response Surface Methodology ◽  
Crude Oil ◽  
Water Content ◽  
Response Surface ◽  
Separation Efficiency ◽  
Corn Oil ◽  
Oil Emulsion ◽  
Optimal Values ◽  
Input Variables ◽  
Oil Emulsions

: In this study, the Sany-glass test was used to evaluate the performance of a new surfactant prepared from corn oil as a demulsifier for crude oil emulsions. Central composite design (CCD), based on the response surface methodology (RSM), was used to investigate the effect of four variables, including demulsifier dosage, water content, temperature, and pH, on the efficiency of water removal from the emulsion. As well, analysis of variance was applied to examine the precision of the CCD mathematical model. The results indicate that demulsifier dose and emulsion pH are two significant parameters determining demulsification. The maximum separation efficiency of 96% was attained at an alkaline pH and with 3500 ppm demulsifier. According to the RSM analysis, the optimal values for the input variables are 40% water content, 3500 ppm demulsifier, 60 °C, and pH 8.

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