Statistical-based approach in potential diagnostic application of urinary nucleosides in urogenital tract cancer

2015 ◽  
Vol 9 (6) ◽  
pp. 577-595 ◽  
Author(s):  
Emilia Daghir-Wojtkowiak ◽  
Wiktoria Struck-Lewicka ◽  
Malgorzata Waszczuk-Jankowska ◽  
Marcin Markuszewski ◽  
Roman Kaliszan ◽  
...  
Keyword(s):  
Urogenital Tract ◽  
Diagnostic Application ◽  
Tract Cancer ◽  
Urinary Nucleosides

Metabolomic Heterogeneity of Urogenital Tract Cancers Analyzed by Complementary Chromatographic Techniques Coupled with Mass Spectrometry

2019 ◽  
Vol 26 (1) ◽  
pp. 216-231 ◽  
Author(s):  
Arlette Yumba-Mpanga ◽  
Wiktoria Struck-Lewicka ◽  
Renata Wawrzyniak ◽  
Marcin Markuszewski ◽  
Marek Roslan ◽  
...  
Keyword(s):  
Tricarboxylic Acid Cycle ◽  
Principal Component ◽  
The United States ◽  
Urogenital Tract ◽  
Control Group ◽  
Tract Cancer ◽  
Patients With Cancer ◽  
Student’S T ◽  
Cancer Studies ◽  
Student’S T Test

Background: In regard to urogenital tract cancer studies, an estimated 340,650 new cases and 58,360 deaths from genital system cancer and about 141,140 new cases and 29330 deaths from urinary system were projected to occur in the United States in 2012. The main drawbacks of currently available diagnostic tests constitute the low specificity, costliness and quite high invasiveness. Objective: The main goal of this pilot study was to determine and compare urine metabolic fingerprints in urogenital tract cancer patients and healthy controls. Method: A comparative analysis of the metabolic profile of urine from 30 patients with cancer of the genitourinary system (bladder (n=10), kidney (n=10) and prostate (n=10)) and 30 healthy volunteers as a control group was provided by LC-TOF/MS and GCQqQ/ MS. The data analysis was performed by the use of U-Mann Whitney test or Student’s t-test, principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA). Results: As a result, 33, 43, and 22 compounds were identified as statistically significant in bladder, prostate and kidney cancer, respectively, compared to healthy groups. Conclusion: Diverse compounds such as purine, sugars, amino acids, nucleosides, organic acids which play a role in purine metabolism, in tricarboxylic acid cycle, in amino acid metabolism or in gut microbiota metabolism were identified. Only two metabolites namely glucocaffeic acid and lactic acid were found to be in common in studied three types of cancer.

Advanced Assessment of the Endogenous Hormone Level as a Potential Biomarker of the Urogenital Tract Cancer

2013 ◽  
Vol 16 (6) ◽  
pp. 463-472 ◽  
Author(s):  
Lucyna Konieczna ◽  
Mariusz Belka ◽  
Tomasz Baczek ◽  
Mateusz Ruszkowski ◽  
Wiktoria Struck ◽  
...  
Keyword(s):  
Hormone Level ◽  
Urogenital Tract ◽  
Endogenous Hormone ◽  
Tract Cancer ◽  
Potential Biomarker

Altered levels of nucleoside metabolite profiles in urogenital tract cancer measured by capillary electrophoresis

2010 ◽  
Vol 53 (5) ◽  
pp. 1305-1312 ◽  
Author(s):  
Ewa Szymańska ◽  
Michał J. Markuszewski ◽  
Marcin Markuszewski ◽  
Roman Kaliszan
Keyword(s):  
Capillary Electrophoresis ◽  
Urogenital Tract ◽  
Tract Cancer ◽  
Metabolite Profiles

Stilbestrol and Urogenital-Tract Cancer in Adolescents and Young Adults

1973 ◽  
Vol 288 (7) ◽  
pp. 354-354 ◽  
Author(s):  
Brian E. Henderson ◽  
Barbara D. A. Benton ◽  
Philip T. Weaver ◽  
George Linden ◽  
James F. Nolan
Keyword(s):  
Young Adults ◽  
Urogenital Tract ◽  
Adolescents And Young Adults ◽  
Tract Cancer

EGFR and HER2 Expression in advanced Biliary Tract Cancer

2008 ◽  
Vol 46 (09) ◽  
Author(s):  
J Harder ◽  
O Waiz ◽  
M Geissler ◽  
HE Blum ◽  
A Schmitt-Gräff ◽  
...  
Keyword(s):  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Her2 Expression ◽  
Tract Cancer
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