Steroid profiles as potential biomarkers in patients with urogenital tract cancer for diagnostic investigations analyzed by liquid chromatography coupled to mass spectrometry

2013 ◽  
Vol 73 ◽  
pp. 108-115 ◽  
Author(s):  
Lucyna Konieczna ◽  
Tomasz Bączek ◽  
Mariusz Belka ◽  
Anna Fel ◽  
Marcin Markuszewski ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Urogenital Tract ◽  
Tract Cancer ◽  
Steroid Profiles ◽  
Potential Biomarkers ◽  
Diagnostic Investigations

scholarly journals Metabolic profiling putatively identifies plasma biomarkers of male infertility using UPLC-ESI-IT-TOFMS

RSC Advances ◽  
2018 ◽  
Vol 8 (46) ◽  
pp. 25974-25982 ◽  
Author(s):  
F. J. Zeng ◽  
H. C. Ji ◽  
Z. M. Zhang ◽  
J. K. Luo ◽  
H. M. Lu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Male Infertility ◽  
Electrospray Ionization ◽  
Metabolic Profiling ◽  
Ion Trap ◽  
Time Of Flight ◽  
Ultra Performance Liquid Chromatography ◽  
Flight Mass Spectrometry ◽  
Potential Biomarkers

Ultra-performance liquid chromatography-electrospray ionization-ion trap-time of flight mass spectrometry combined with chemometrics methods was used to discover potential biomarkers of male infertility based on untargeted plasma metabolomics.

scholarly journals A Metabonomics Profiling Study on Phlegm Syndrome and Blood-Stasis Syndrome in Coronary Heart Disease Patients Using Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Linlin Zhao ◽  
Ling Wan ◽  
Xinjian Qiu ◽  
Ruomeng Li ◽  
Shimi Liu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Liquid Chromatography ◽  
Acid Metabolism ◽  
Blood Stasis ◽  
Blood Stasis Syndrome ◽  
Flight Mass Spectrometry ◽  
Potential Biomarkers ◽  
Phlegm Syndrome

A metabonomics approach based on liquid chromatography/quadrupole time-of-flight mass spectrometry (LC-Q-TOF/MS) was utilized to obtain potential biomarkers of coronary heart disease (CHD) patients and investigate the ZHENG types differentiation in CHD patients. The plasma samples of 20 CHD patients with phlegm syndrome, 20 CHD patients with blood-stasis syndrome, and 16 healthy volunteers were collected in the study. 26 potential biomarkers were identified in the plasma of CHD patients and 19 differential metabolites contributed to the discrimination of phlegm syndrome and blood-stasis syndrome in CHD patients(VIP>1.5; P<0.05)which mainly involved purine metabolism, pyrimidine metabolism, amino acid metabolism, steroid biosynthesis, and arachidonic acid metabolism. This study demonstrated that metabonomics approach based on LC-MS was useful for studying pathologic changes of CHD patients and interpreting the differentiation of ZHENG types (phlegm and blood-stasis syndrome) in traditional Chinese medicine (TCM).

New potential biomarkers for mesterolone misuse in human urine by liquid chromatography quadrupole time-of-flight mass spectrometry

2015 ◽  
Vol 50 (1) ◽  
pp. 153-159 ◽  
Author(s):  
Jianghai Lu ◽  
María Fernández-Álvarez ◽  
Sheng Yang ◽  
Genye He ◽  
Youxuan Xu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Human Urine ◽  
Time Of Flight ◽  
Flight Mass Spectrometry ◽  
Potential Biomarkers
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