scholarly journals THERAPEUTIC IMPORTANCE OF CURCUMIN WITH A SPECIAL EMPHASIS ON MDR CANCER CELLS AND THE FACTORS INFLUENCING PHARMACODYNAMICS.

2021 ◽  
pp. 429-441
Author(s):  
MUHASINA.K.M ◽  
Dhanabal S. Palaniswamy ◽  
Deepika.N.P ◽  
Divya jyothi Palati
Keyword(s):  
Cancer Cells ◽  
Neurological Disorders ◽  
Metabolic Disorders ◽  
Therapeutic Agent ◽  
Inflammatory Diseases ◽  
Curcuma Longa ◽  
Vascular Diseases ◽  
Immune Disorders ◽  
Pharmacological Activities ◽  
Cardio Vascular

Curcuma longa or turmeric is a plant that is used as a spice and as a phytoconstituent in many formulations from Vedic age. Curcuminoids are the most important Phyto constituents present in turmeric with various pharmacological activities. The present study reveals various pharmacological activities of curcumin with special emphasis on MDR cancer cells. The curcuminoids are the Phyto constituents showing potent activity against neurological disorders, cardio vascular diseases, auto immune disorders, Metabolic disorders, cancer, inflammatory diseases, Skin allergies and disorders. This review give emphasis on anticancer activity of curcumin and its possible mechanism of actions. Many studies revealing that various formulations and combination therapy of curcumin is increasing its bioavailability and there by effective against various diseases. This review is lighting to a treasure buried inside the soil a potential therapeutic agent without side effects.

scholarly journals Examination of metabolic disorders in postmenopausal women

2014 ◽  
Vol 18 (2 (70)) ◽  
Author(s):  
S. Y. Kosilova
Keyword(s):  
Diabetes Mellitus ◽  
Postmenopausal Women ◽  
Metabolic Disorders ◽  
Vascular Diseases ◽  
Insulin Dependent Diabetes Mellitus ◽  
Dependent Diabetes Mellitus ◽  
C Reactive Protein ◽  
Diabetes Mellitus Type Ii ◽  
Reactive Protein ◽  
Cardio Vascular

Climacteric period constitutes a third of a woman’s life. The longer was the period of menopause the more intensive were the signs of obesity, as well as increase of lipid and carbohydrate metabolism, increase of C-reactive protein basal level. C-reactive protein is a risk factor of development of vascular diseases. Increased level of C-reactive protein was found in 74 % of women with obesity. In 30 % of women with longer menopause and more pronounced metabolic disorders, non-insulin dependent diabetes mellitus, Type II was diagnosed, and in 42 % of hypertensive disorders were found. Timely diagnostics and correction of metabolic disorders will reduce the risk of development of cardio-vascular diseases and diabetes mellitus in postmenopausal women, improving their quality of life.

scholarly journals Thalamic Lesions: A Radiological Review

2014 ◽  
Vol 2014 ◽  
pp. 1-17 ◽  
Author(s):  
Dimitri Renard ◽  
Giovanni Castelnovo ◽  
Chantal Campello ◽  
Stephane Bouly ◽  
Anne Le Floch ◽  
...  
Keyword(s):  
Metabolic Disorders ◽  
Inflammatory Diseases ◽  
Vascular Diseases ◽  
Clinical State ◽  
Thalamic Lesion ◽  
Mri Sequences ◽  
Thalamic Lesions ◽  
Signal Changes ◽  
Mri Characteristics ◽  
Over Time

Background. Thalamic lesions are seen in a multitude of disorders including vascular diseases, metabolic disorders, inflammatory diseases, trauma, tumours, and infections. In some diseases, thalamic involvement is typical and sometimes isolated, while in other diseases thalamic lesions are observed only occasionally (often in the presence of other typical extrathalamic lesions).Summary. In this review, we will mainly discuss the MRI characteristics of thalamic lesions. Identification of the origin of the thalamic lesion depends on the exact localisation inside the thalamus, the presence of extrathalamic lesions, the signal changes on different MRI sequences, the evolution of the radiological abnormalities over time, the history and clinical state of the patient, and other radiological and nonradiological examinations.

scholarly journals Identifying the Therapeutic Significance of Mesenchymal Stem Cells

Cells ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 1145 ◽  
Author(s):  
Vineet Kumar Mishra ◽  
Hui-Hsuan Shih ◽  
Farzana Parveen ◽  
David Lenzen ◽  
Etsuro Ito ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Metabolic Disorders ◽  
Cellular Therapy ◽  
Inflammatory Diseases ◽  
Innate Immune ◽  
Immune Disorders ◽  
Therapeutic Role ◽  
Beneficial Effects ◽  
Immense Potential

The pleiotropic behavior of mesenchymal stem cells (MSCs) has gained global attention due to their immense potential for immunosuppression and their therapeutic role in immune disorders. MSCs migrate towards inflamed microenvironments, produce anti-inflammatory cytokines and conceal themselves from the innate immune system. These signatures are the reason for the uprising in the sciences of cellular therapy in the last decades. Irrespective of their therapeutic role in immune disorders, some factors limit beneficial effects such as inconsistency of cell characteristics, erratic protocols, deviating dosages, and diverse transfusion patterns. Conclusive protocols for cell culture, differentiation, expansion, and cryopreservation of MSCs are of the utmost importance for a better understanding of MSCs in therapeutic applications. In this review, we address the immunomodulatory properties and immunosuppressive actions of MSCs. Also, we sum up the results of the enhancement, utilization, and therapeutic responses of MSCs in treating inflammatory diseases, metabolic disorders and diabetes.

scholarly journals Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1084
Author(s):  
Milad Ashrafizadeh ◽  
Ali Zarrabi ◽  
Farid Hashemi ◽  
Amirhossein Zabolian ◽  
Hossein Saleki ◽  
...  
Keyword(s):  
Side Effects ◽  
Antitumor Activity ◽  
Cancer Cells ◽  
Cancer Metastasis ◽  
Curcuma Longa ◽  
Chemotherapeutic Agents ◽  
Pharmacological Activities ◽  
Anticancer Mechanism ◽  
Dose Dependent ◽  
Potential Antitumor

Doxorubicin (DOX) is a well-known chemotherapeutic agent extensively applied in the field of cancer therapy. However, similar to other chemotherapeutic agents such as cisplatin, paclitaxel, docetaxel, etoposide and oxaliplatin, cancer cells are able to obtain chemoresistance that limits DOX efficacy. In respect to dose-dependent side effect of DOX, enhancing its dosage is not recommended for effective cancer chemotherapy. Therefore, different strategies have been considered for reversing DOX resistance and diminishing its side effects. Phytochemical are potential candidates in this case due to their great pharmacological activities. Curcumin is a potential antitumor phytochemical isolated from Curcuma longa with capacity of suppressing cancer metastasis and proliferation and affecting molecular pathways. Experiments have demonstrated the potential of curcumin for inhibiting chemoresistance by downregulating oncogene pathways such as MMP-2, TGF-β, EMT, PI3K/Akt, NF-κB and AP-1. Furthermore, coadministration of curcumin and DOX potentiates apoptosis induction in cancer cells. In light of this, nanoplatforms have been employed for codelivery of curcumin and DOX. This results in promoting the bioavailability and internalization of the aforementioned active compounds in cancer cells and, consequently, enhancing their antitumor activity. Noteworthy, curcumin has been applied for reducing adverse effects of DOX on normal cells and tissues via reducing inflammation, oxidative stress and apoptosis. The current review highlights the anticancer mechanism, side effects and codelivery of curcumin and DOX via nanovehicles.

Role of Emotional Processes in Cardio-vascular Diseases

2012 ◽  
Author(s):  
Suman Balhara ◽  
Nov Rattan Sharma ◽  
Amrita Yadav
Keyword(s):  
Vascular Diseases ◽  
Emotional Processes ◽  
Cardio Vascular

A Review on Heart Disease Detection Techniques

2017 ◽  
Vol 7 (7) ◽  
pp. 395
Author(s):  
. Anika ◽  
Navpreet Kaur
Keyword(s):  
Machine Learning ◽  
Heart Disease ◽  
Review Paper ◽  
Vascular Diseases ◽  
Disease Detection ◽  
Automated Classification ◽  
Feature Extraction Method ◽  
Detection Techniques ◽  
Cardio Vascular ◽  
Public Domain Software

The paper exhibits a formal audit on early detection of heart disease which are the major cause of death. Computational science has potential to detect disease in prior stages automatically. With this review paper we describe machine learning for disease detection. Machine learning is a method of data analysis that automates analytical model building.Various techniques develop to predict cardiac disease based on cases through MRI was developed. Automated classification using machine learning. Feature extraction method using Cell Profiler and GLCM. Cell Profiler a public domain software, freely available is flourished by the Broad Institute's Imaging Platform and Glcm is a statistical method of examining texture .Various techniques to detect cardio vascular diseases.

Biological Aspects and Clinical Applications of Mesenchymal Stem Cells: Key Features You Need to be Aware of.

2020 ◽  
Vol 21 ◽  
Author(s):  
Mohammad Saeedi ◽  
Muhammad Sadeqi Nezhad ◽  
Fatemeh Mehranfar ◽  
Mahdieh Golpour ◽  
Mohammad Ali Esakandari ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cancer Cells ◽  
Immune Modulation ◽  
Adult Stem Cells ◽  
Inflammatory Diseases ◽  
High Capacity ◽  
Genetically Engineered ◽  
Cartilage Cells ◽  
Biological Aspects

: Mesenchymal stem cells (MSCs), a form of adult stem cells, are known to have a self-renewing property and the potential to specialize into a multitude of cells and tissues such as adipocytes, cartilage cells, and fibroblasts. MSCs can migrate and home to the desired target zone where inflammation is present. The unique characteristics of MSCs in repairing, differentiation, regeneration, and its high capacity of immune modulation has attracted tremendous attention for exerting them in clinical purposes, as they contribute to tissue regeneration process and anti-tumor activity. The MSCs-based treatment has demonstrated remarkable applicability towards various diseases such as heart and bone malignancies, and cancer cells. Importantly, genetically engineered MSCs, as a state-of-the-art therapeutic approach, could address some clinical hurdles by systemic secretion of cytokines and other agents with a short half-life and high toxicity. Therefore, understanding the biological aspects and the characteristics of MSCs is an imperative issue of concern. Herein, we provide an overview of the therapeutic application and the biological features of MSCs against different inflammatory diseases and cancer cells. We further shed light on MSCs physiological interaction, such as migration, homing, and tissue repairing mechanisms with different healthy and inflamed tissues.

Natural Products for Regulating Macrophages M2 Polarization

2020 ◽  
Vol 15 (7) ◽  
pp. 559-569 ◽  
Author(s):  
Zhen Chang ◽  
Youhan Wang ◽  
Chang Liu ◽  
Wanli Smith ◽  
Lingbo Kong
Keyword(s):  
Molecular Mechanisms ◽  
Inflammatory Diseases ◽  
Therapeutic Strategies ◽  
Research Progress ◽  
Cellular Mechanisms ◽  
Pharmacological Activities ◽  
Current Review ◽  
M2 Polarization ◽  
Macrophages Polarization ◽  
Herbal Plants

Macrophages M2 polarization have been taken as an anti-inflammatory progression during inflammation. Natural plant-derived products, with potential therapeutic and preventive activities against inflammatory diseases, have received increasing attention in recent years because of their whole regulative effects and specific pharmacological activities. However, the molecular mechanisms about how different kinds of natural compounds regulate macrophages polarization still unclear. Therefore, in the current review, we summarized the detailed research progress on the active compounds derived from herbal plants with regulating effects on macrophages, especially M2 polarization. These natural occurring compounds including flavonoids, terpenoids, glycosides, lignans, coumarins, alkaloids, polyphenols and quinones. In addition, we extensively discussed the cellular mechanisms underlying the M2 polarization for each compound, which could provide potential therapeutic strategies aiming macrophages M2 polarization.

scholarly journals Cytotoxicity and Apoptosis Effects of Curcumin Analogue (2E,6E)-2,6-Bis(2,3-Dimethoxybenzylidine) Cyclohexanone (DMCH) on Human Colon Cancer Cells HT29 and SW620 In Vitro

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1261
Author(s):  
Nurul Fattin Che Rahim ◽  
Yazmin Hussin ◽  
Muhammad Nazirul Mubin Aziz ◽  
Nurul Elyani Mohamad ◽  
Swee Keong Yeap ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Cell Lines ◽  
Curcuma Longa ◽  
Metastatic Colon Cancer ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Sw620 Cell

Colorectal cancer (CRC) is the third most common type of cancer worldwide and a leading cause of cancer death. According to the Malaysian National Cancer Registry Report 2012–2016, colorectal cancer was the second most common cancer in Malaysia after breast cancer. Recent treatments for colon cancer cases have caused side effects and recurrence in patients. One of the alternative ways to fight cancer is by using natural products. Curcumin is a compound of the rhizomes of Curcuma longa that possesses a broad range of pharmacological activities. Curcumin has been studied for decades but due to its low bioavailability, its usage as a therapeutic agent has been compromised. This has led to the development of a chemically synthesized curcuminoid analogue, (2E,6E)-2,6-bis(2,3-dimethoxybenzylidine) cyclohexanone (DMCH), to overcome the drawbacks. This study aims to examine the potential of DMCH for cytotoxicity, apoptosis induction, and activation of apoptosis-related proteins on the colon cancer cell lines HT29 and SW620. The cytotoxic activity of DMCH was evaluated using the [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) cell viability assay on both of the cell lines, HT29 and SW620. To determine the mode of cell death, an acridine orange/propidium iodide (AO/PI) assay was conducted, followed by Annexin V/FITC, cell cycle analysis, and JC-1 assay using a flow cytometer. A proteome profiler angiogenesis assay was conducted to determine the protein expression. The inhibitory concentration (IC50) of DMCH in SW620 and HT29 was 7.50 ± 1.19 and 9.80 ± 0.55 µg/mL, respectively. The treated cells displayed morphological features characteristic of apoptosis. The flow cytometry analysis confirmed that DMCH induced apoptosis as shown by an increase in the sub-G0/G1 population and an increase in the early apoptosis and late apoptosis populations compared with untreated cells. A higher number of apoptotic cells were observed on treated SW620 cells as compared to HT29 cells. Human apoptosis proteome profiler analysis revealed upregulation of Bax and Bad proteins and downregulation of Livin proteins in both the HT29 and SW620 cell lines. Collectively, DMCH induced cell death via apoptosis, and the effect was more pronounced on SW620 metastatic colon cancer cells, suggesting its potential effects as an antimetastatic agent targeting colon cancer cells.

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