scholarly journals Hubungan status pestisida dengan status gangguan akibat kekurangan yodium (GAKY) anak SD pada daerah endemik GAKY Kabupaten Dairi

2008 ◽  
Vol 4 (3) ◽  
pp. 118
Author(s):  
Maryanes Maryanes ◽  
Wiryatun Lestariana ◽  
Untung S Widodo
Keyword(s):  
Thyroid Gland ◽  
Iodine Deficiency ◽  
Significant Relationship ◽  
Elementary School Children ◽  
Urinary Iodine ◽  
Urinary Iodine Excretion ◽  
Iodine Deficiency Disorders ◽  
Chi Square ◽  
Iodine Excretion ◽  
The Relationship

Background: Thyroxin plays important role in the metabolism of carbohydrate, protein and cholesterol, and in the process of growth. Iodine deficiency disorder not only can be caused by lack of iodine substance but also another competition factor, which is a pollutant substance which is goitergenic (pesticide). This goitergenic substance interferes hormonogenesis of thyroid causing enlargement of thyroid gland known as goiter.Objective: This study was aimed at examining the relationship between status of pesticide and status of iodine deficiency disorders (urinary iodine excretion) of elementary school children and the difference between them based on level of their endemic in Dairi District.Methods: This was an observational study using a cross-sectional design. Palpation of thyroid gland was made to determine the level of endemic; concentration of blood cholinesterase was determined using tinto meter kit; urinary iodine excretion was analyzed with the ammonium persulfate digestion method. Data was analyzed with chi square and anova.Results: Chi square test indicated that the relationship between the concentration of blood cholinesterase and urinary iodine excretion was significant (p<0.05) with OR 11.1 and the relationship between concentration of cholinesterase and iodine deficiency disorders (palpation) was not significant (p>0.05) with OR 1.3. Anova test, based on endemic, indicated that there was a significant difference between the concentration of blood cholinesterase and urinary iodine excretion (p<0.05).Conclusion: There was significant relationship between status of pesticide (concentration of blood cholinesterase) and status of iodine deficiency disorder based on urinary iodine excretion and there was no significant relationship between concentration of cholinesterase and iodine deficiency disorders based on the result of palpation. There was a difference in the average status of pesticide and iodine deficiency disorders status among the elementary school children based on their endemic.

THE RELATIONSHIP BETWEEN SERUM PROTEIN-BOUND IODINE LEVELS AND URINARY IODINE EXCRETION AND SERUM THYROTROPHIN CONCENTRATIONS IN SUBJECTS FROM AN ENDEMIC GOITRE AREA IN CENTRAL JAVA

1978 ◽  
Vol 88 (3) ◽  
pp. 474-481 ◽  
Author(s):  
G. Hennemann ◽  
R. Djokomoeljanto ◽  
R. Docter ◽  
B. M. Goslings ◽  
C. van Hardeveld ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Iodine Deficiency ◽  
Urinary Iodine ◽  
Serum Levels ◽  
Iodine Intake ◽  
Urinary Iodine Excretion ◽  
Central Java ◽  
Iodine Excretion ◽  
The Relationship ◽  
Serum Tsh

ABSTRACT Urinary 127I excretion, 24 h thyroid 131I uptake and serum values of thyrotrophin (TSH), triiodothyronine (T3) and protein-bound iodine (PBI) were measured in subjects from an area with severe (Segni) and moderate (Londjong) iodine deficiency. In Segni, 90 non-cretinous subjects and 40 cretins were studied. In both sub-groups from Segni non-compensated iodine deficiency was found. Although iodine excretion in these sub-groups was the same (mean: ± sd, 127I μg per g creatinine; non-cretins 16.9 ± 10.1 and cretins 15.2 ± 8.0) thyroid hormone serum levels were less in the cretins probably due to additional primary thyroid failure. In the subjects (non-cretins plus cretins) from Segni a positive relationship (r=0.39, P < 0.001) was found between urinary 127I excretion and serum PBI. Moreover in the same subjects a negative correlation was found between serum PBI and TSH (r=0.43; P < 0.001) while serum T3 did not correlate with TSH. In the Londjong area (mean ± sd 127I urinary excretion: 41.6 ± 18.6 μg per g creatinine) iodine deficiency appeared to be compensated in 52 subjects studied since mean serum levels of TSH, PBI and T3 were within normal range. No correlation between PBI and serum TSH was found. PBI too did not correlate with iodine excretion despite the fact that 37 subjects excreted less than 48 μg 127I per g creatinine below which value iodine excretion varied in all but one of the studied subjects from Segni. It is suggested on the basis of a difference in the average iodine intake between the groups from Segni and Londjong, that lack of "iodine buffer capacity" of the thyroid gland in the Segni subjects leads to a situation where changes in iodine intake are readily reflected in T4 production resulting in the correlation found between PBI and urinary excretion in this group.

scholarly journals A study to assess the prevalence of iodine deficiency disorders in Betul district, Madhya Pradesh, India

2019 ◽  
Vol 6 (9) ◽  
pp. 3999
Author(s):  
Sudarshan Kushwah ◽  
Akhil R. Nair ◽  
Jeevan Singh Meena ◽  
Shipra Verma ◽  
Harshima Sawlani ◽  
...  
Keyword(s):  
Public Health ◽  
Iodine Deficiency ◽  
Urinary Iodine ◽  
Public Health Problem ◽  
Iodine Concentration ◽  
Madhya Pradesh ◽  
Urinary Iodine Excretion ◽  
Iodine Deficiency Disorders ◽  
Neurological Damage ◽  
Iodine Excretion

Background: Iodine deficiency disorders (IDD) constitute the single largest cause of preventable neurological damage worldwide. Majority of consequences of IDD are invisible and irreversible but at the same time these are preventable. The study was conducted to assess the prevalence of goiter in school children aged 6-12 years, to estimate the urinary iodine excretion and to assess the level of iodine concentration in salt samples obtained from households of selected school children.Methods: Population proportionate to size sampling. Sample size was 90 primary school-going children of age 6-12 years in each selected village, total 2700 from 30 villages/wards in Betul district, Madhya Pradesh, India.Results: The prevalence of goiter among the 6-12 years children was found to be 32.06%. Females had higher prevalence compared to males. Of the 540 salt samples, 370 (68.4%) had iodine concentration ≥15 ppm at household level.Conclusions: IDD is a mild public health problem in Betul district.

scholarly journals Iodine deficiency disorders in Europe

2001 ◽  
Vol 4 (2b) ◽  
pp. 529-535 ◽  
Author(s):  
Paolo Vitti ◽  
Teresa Rago ◽  
Fabrizio Aghini-Lombardi ◽  
Aldo Pinchera
Keyword(s):  
Iodine Deficiency ◽  
Urinary Iodine ◽  
Iodine Intake ◽  
European Countries ◽  
Neurological Deficits ◽  
Urinary Iodine Excretion ◽  
Iodine Deficiency Disorders ◽  
Iodine Prophylaxis ◽  
Beneficial Impact ◽  
Iodine Excretion

AbstractIodine deficiency disorders (IDD) are related to the degree of iodine deficiency. In european countries, characterized by mild to moderate iodine deficiency, neurological deficits or minor neuropsychological impairments have been described. Urinary iodine excretion (UIE) ranged from 30 to 170 mcg/L, 141 millions of people were at risk of IDD, 97 millions were affected by goiter and 0.9 millions had an impaired mental development.Iodine prophylaxis is devoid of adverse reactions with the exception of sporadic cases of transitory hyperthyroidism, associated to the severity of iodine deficiency before the prophylaxis. The International Council for Control of IDD recommends an universal iodine prophylaxis, instituted gradually in severe iodine deficient countries. The total cost of universal iodine prophylaxis is very cheap compared to the social cost of goiter and cretinism.In conclusion, most european countries are still characterized by mild to moderate iodine deficiency. Iodine prophylaxis programs are already operating, its cost is irrelevant with respect to the undebatable beneficial impact on the health. Adverse effects are not observed except in severe iodine deficient areas where iodine intake was abruptly increased.

Assessment of Iodine Status in Iranian Students Aged 8-10 Years: Monitoring the National Program for the Prevention and Control of Iodine Deficiency Disorders in 2016

2020 ◽  
Author(s):  
Mansoureh REZAIE ◽  
Sepideh DOLATI ◽  
Alemeh HARIRI FAR ◽  
Zahra ≈ Zahra ABDOLLAH ◽  
Said SADEGHIAN
Keyword(s):  
Iodine Deficiency ◽  
Prevention And Control ◽  
Urinary Iodine ◽  
Urinary Iodine Excretion ◽  
Relative Distribution ◽  
National Program ◽  
Iodine Deficiency Disorders ◽  
Iodine Status ◽  
Iodine Excretion ◽  
And Control

Background: Iodine is a key element in the synthesis of thyroid hormones. The deficiency of the secretion of them will Reduce IQ, disturbance in the psychomotor growth and shortened height. Urinary iodine is a good indicator of iodine intake status. Urinary iodine status in at-risk groups is one of the most important indicators of community status. Methods: All 56 universities/medical faculties in Iran should determine and report median urinary iodine and its relative distribution in school children aged 8 to 10 yr, to determine the status of urine output. The sample size in each university/college is 240 students and the cluster sampling method (48 clusters in each area in 2016) and based on probability Measurement. The amount of urinary iodine was measured quantitatively by acid digestion. Results: The mean urinary iodine excretion was estimated at 18.61 μg/dl. The median urinary iodine concentration in 52 universities was sufficient, and the national mean of urinary iodine excretion rate was 19.3 μg/dl. The iodine status was estimated in the optimal range in 65.6% of the students and in only 4.7% in the range of moderate and severe deficits, based on the urinary iodine index. Conclusion: Iodine is sufficient in most parts of the country. The implementation of the country’s national program for the prevention and control of iodine deficiency disorders has made more important the quality control of the collaborative laboratories of this program than before. Moreover, it is absolutely essential to avoid excessive iodine in order to prevent possible side effects.

Iodized salt prophylaxis of endemic goiter: an experience in Toscana (Italy)

1993 ◽  
Vol 129 (6) ◽  
pp. 497-500 ◽  
Author(s):  
F Aghini-Lombardi ◽  
A Pinchera ◽  
L Antonangeli ◽  
T Rago ◽  
GF Fenzi ◽  
...  
Keyword(s):  
Iodine Deficiency ◽  
Endemic Goiter ◽  
Urinary Iodine ◽  
Thyroid Volume ◽  
Iodized Salt ◽  
Urinary Iodine Excretion ◽  
Goiter Prevalence ◽  
Iodine Excretion ◽  
Health Organization ◽  
Legislative Measures

It is well established that iodine supplementation is effective in correcting iodine deficiency and reducing goiter prevalence. In Italy, legislation has allowed the production of iodized salt since 1972, but its consumption is on a voluntary basis. In the present study, the efficacy of legislative measures that made compulsory the availability of iodized salt in foodstores has been evaluated. Urinary iodine excretion and thyroid size, scored according to Pan American Health Organization recommendations, were determined prior to (1981) and 10 years after (1991) the introduction of legislative measures in the whole schoolchildren population residing in a restricted area of the Tuscan Appennines. Moreover, in 1991, thyroid volume was determined by ultrasonography. In 1981, mean urinary iodine excretion was 47.1±22.4 mg/kg creatinine (0.412 μmol/l) and goiter prevalence was 60%, indicating a moderate iodine deficiency. Eighty of the families subsequently used iodized salt on a regular basis; as a result of this excellent compliance, in 1991 the mean urinary iodine excretion increased to 129.7±73 mg/kg creatinine (1.24 μmol/l) and goiter prevalence dropped to 8.1%. The results of this study underline the effectiveness of iodine prophylaxis in correcting iodine deficiency and abating endemic goiter in schoolchildren, and suggest that implementation of measures that make compulsory the availability of iodized salt in foodstores overcomes the fact that there is no law governing the exclusive production and trading of iodized salt.

scholarly journals Effects of Giving Iodized Salt, Counseling of Iodine and Goitrogenic Sources of Food in Mothers Who Have Elementary School Children Against Urinary Iodine Excretion

2019 ◽  
Vol 3 (5) ◽  
pp. 238-243
Author(s):  
I Ketut Swiryajaya ◽  
Iswari Pauzi
Keyword(s):  
Elementary School ◽  
Treatment Group ◽  
School Children ◽  
Elementary School Children ◽  
Urinary Iodine ◽  
Iodized Salt ◽  
Control Group ◽  
Urinary Iodine Excretion ◽  
Iodine Excretion ◽  
The Mean

As a result of IDD is the occurrence of impaired child growth makes researchers interested in conducting research on "Provision of iodized salt, food counseling about the source of iodine and goitrogenic substances with urinary iodine excretion status in elementary school children". Research on IDD is often carried out in primary school-age children, aged 6-12 years because of their vulnerability to iodine deficiency. The purpose of this study was to determine the effect of iodized salt interventions and counseling patterns of iodized and goitrogenic food consumption patterns on levels of urinary yodiun excretion in families with elementary school children. Research methods: The design of this study included quasi-experimental using a specific design that is "pre and post test control group design". The study population was elementary school children with a sample size of 30 children aged 9 -12 years in each group. Data collected included the consumption of nutrients by the 24-hour recall method, the results of urine iodine examination by the spectrophotometric method. The collected data is then analyzed with an independent sample T test. The results showed there were differences in urinary yodiun excretion levels in the two groups (treatment and control), while the mean in the treatment group before intervention was 106.97 ug / L and after the intervention was 43.19 ug / L. Whereas in the control group, the level of urinary yodiun excretion before intervention was 117.30 μg / L and after the intervention was 243.19 μg / L. The mean of respondents who consumed goitrogenic sources in the treatment group before the intervention (Yes = 63%, No = 37%), after the intervention (Yes = 23%, No = 77%). Whereas in the Control group before the intervention (Yes = 56%, No = 73%), after the intervention (Yes = 23%, No = 77%). The average amount of protein consumption before treatment was 47.91 µg/L ± 6.54 and 50.15 µg/L ± 12.52 after treatment. For consumption, an increase with a mean before treatment was 89.88 µg/L ± 38.45 and after treatment was 113 µg/L ± 26. The results of the independent sample t-test showed that in the treatment group there was no significant difference between after and before the intervention (p = 0.058). Whereas in the control group there were significant differences between before and after the intervention (p = 0.002). It can be concluded that there are many factors that need to be controlled in the provision of interventions, especially the use, type of salt and goitronic as well as the method of examination of iodine analysis in urine. Keywords: iodized salt; iodine food sources; goitrogenic; urinary iodine excretion

Goiter Prevalence and Urinary Iodine Excretion in Schoolchildren of Jordan

2004 ◽  
Vol 74 (4) ◽  
pp. 301-304 ◽  
Author(s):  
Kharabsheh ◽  
Belbesi ◽  
Qarqash ◽  
Azizi
Keyword(s):  
Iodine Deficiency ◽  
Eastern Mediterranean ◽  
Urinary Iodine ◽  
Eastern Mediterranean Region ◽  
Urinary Iodine Excretion ◽  
Major Health Problem ◽  
Salt Iodization ◽  
Goiter Prevalence ◽  
Iodine Excretion ◽  
Monitoring Survey

Iodine deficiency disorders (IDD) are considered a major health problem in the eastern Mediterranean region. In Jordan, an IDD assessment was performed in 1993 following which, a salt iodization and consumption program was implemented and a monitoring survey performed in 2000. In schoolchildren 8 to 10 years of age (2457 in 1993 and 2601 in 2000) goiter was graded according to WHO classification. Urinary iodine was measured in 10% of the children in 1993 and in all of them in 2000. Percent of iodine consumption in households was assessed by rapid kit test in 2000. Prevalence of goiter was 37.7 and 32.1% and median urinary iodine was 40 and 154 mug/L, in 1993 and 2000, respectively. Before salt iodization, the prevalence of goiter and severity of iodine deficiency was more pronounced in rural regions and in the southern part of Jordan. In 2000, all but one governorate had a median urinary iodine (MUI) of above 100 mug/L. The percentage of urinary iodine levels < 50 mug in two governorates was > 20%. Iodine consumption rate of households was 88.3% throughout the country, but was < 70% in three governorates. It is concluded that moderate and severe IDD existed before 1993 in Jordan. Although the iodized salt program has been successful in optimizing MUI, the program for the control of IDD needs further improvement.

Urinary iodine excretion in Belarus children

1995 ◽  
Vol 133 (2) ◽  
pp. 216-217 ◽  
Author(s):  
TA Mityukova ◽  
LN Astakhova ◽  
LD Asenchyk ◽  
MM Orlov ◽  
L VanMiddlesworth
Keyword(s):  
Thyroid Cancer ◽  
Iodine Deficiency ◽  
Urinary Iodine ◽  
Iodine Intake ◽  
Urine Samples ◽  
Urinary Iodine Excretion ◽  
University Of Tennessee ◽  
Iodine Excretion

Mityukova TA, Astakhova LN, Asenchyk LD, Orlov MM, VanMiddlesworth L. Urinary iodine excretion in Belarus children. Eur J Endocrinol 1995;133:216–7. ISSN 0804–4643. Casual urine samples were collected to determine iodine excretion of 1680 Belarus children during 1990–1994. The subjects, 8–16 years old, were from nine different regions of Belarus; 60% were from the Gomel oblast, which has been associated with relatively high levels of radioiodine fallout and increased incidence of thyroid cancer. Most of the median values indicate borderline/low iodine intake or mild iodine deficiency. Ranges were wide but 163 children excreted < 20 μgI/l urine and they should be considered severely deficient in iodine. L VanMiddlesworth, Dept. of Physiology and Biophysics, University of Tennessee, 894 Union Avenue, Memphis, TN 38163, USA

Decrease of incidence of toxic nodular goitre in a region of Switzerland after full correction of mild iodine deficiency

1995 ◽  
Vol 132 (5) ◽  
pp. 546-549 ◽  
Author(s):  
Benedikt L Baltisberger ◽  
Christoph E Minder ◽  
Hans Bürgi
Keyword(s):  
Iodine Deficiency ◽  
Control Level ◽  
Urinary Iodine ◽  
Urinary Iodine Excretion ◽  
Nodular Goitre ◽  
Beneficial Effects ◽  
Severe Deficiency ◽  
Iodine Excretion ◽  
Full Correction ◽  
Toxic Nodular Goitre

Baltisberger BL, Minder CE, Bürgi H. Decrease of incidence of toxic nodular goitre in a region of Switzerland after full correction of mild iodine deficiency. Eur J Endocrinol 1995;132:546–9. ISSN 0804–4643 In 1980 the iodide content of salt was increased in Switzerland from 7.5 to 15 mg/kg. This raised the mean urinary iodine excretion from 90 (indicating mild iodine deficiency) to 150 μg/g creatinine. We examined whether this public health measure was followed by a change of the incidence of hyperthyroidism in a defined catchment area of 109 000 persons. Except for a 27% rise in the first year of the new salt, the total incidence of hyperthyroidism declined steadily to reach 44% of the control level in 1988/89. This was due to a decrease mostly of toxic nodular goitre (minus 73%), less so of Graves' disease (minus 33%). We conclude that correction of mild iodine deficiency has beneficial effects on the incidence of hyperthyroidism, contrary to what is seen initially after correction of severe deficiency. H Bürgi, Department of Medicine, Bürgerspital, CH-4500 Solothurn, Switzerland

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