scholarly journals Alginate-Graphene Oxide Biocomposite Sorbent for Rapid and Selective Extraction of Non-Steroidal Anti-Inflammatory Drugs Using Micro-Solid Phase Extraction

2019 ◽  
Vol 19 (3) ◽  
pp. 684 ◽  
Author(s):  
Mohammad Salim Tabish ◽  
Nor Suhaila Mohamad Hanapi ◽  
Wan Nazihah Wan Ibrahim ◽  
Nor’ashikin Saim ◽  
Noorfatimah Yahaya
Keyword(s):  
Graphene Oxide ◽  
Solid Phase Extraction ◽  
Electrostatic Interactions ◽  
High Performance ◽  
Solid Phase ◽  
Tap Water ◽  
Phase Extraction ◽  
Composite Sorbent ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

In this work, a bio-composite sorbent, alginate incorporated graphene oxide (Alg/GO) is prepared for the micro solid phase extraction of non-steroidal anti-inflammatory drugs (NSAIDs) from water samples. The sorbent was prepared in a suspended solution form at a ratio of 0.3:1 (w/v %) of graphene oxide (GO) and alginate (Alg). The chemical structure, morphology and surface area of the composite beads were characterized using Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM) and Brunauer–Emmett–Teller (BET). GO showed good miscibility and well dispersion through intermolecular hydrogen bonds and electrostatic interactions within the Alg matrix. The synthesized sorbent was applied for the determination of the selected drugs in a tap water sample using micro-solid phase extraction technique and was analyzed by high-performance liquid chromatography-ultraviolet detector (HPLC-UV). The results showed good linearity in the range of 10–1000 µg L–1 with correlation coefficients (r ≥ 0.9979), low detection limits (LOD) between 3.1–4.6 µg L–1, excellent relative recoveries in the range of 99.6–102.1% and good reproducibility (RSD ≤ 3.9%). Thus, these validated results showed that Alg/GO could be potential and useful as a bio-composite sorbent for micro-solid phase extraction for the analysis of targeted drugs from aqueous matrices.

scholarly journals Rapid Magnetic Solid-Phase Extraction Based on Graphene Oxide/Magnetite Nanoparticles for the Determination of Non-Steroidal Anti-Inflammatory Drugs and Bisphenol-A in Tap Water

2019 ◽  
Vol 31 (6) ◽  
pp. 1294-1300 ◽  
Author(s):  
U.A.A. UNGKU ABDULLAH ◽  
N.S. MOHAMAD HANAPI ◽  
W.N.W. IBRAHIM ◽  
S. SAIFUL AZHAR ◽  
N.S. ISHAK ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Bisphenol A ◽  
Solid Phase Extraction ◽  
Solid Phase ◽  
Tap Water ◽  
Magnetic Solid Phase Extraction ◽  
Phase Extraction ◽  
Magnetic Solid ◽  
Inflammatory Drugs

A simple and rapid magnetic solid-phase extraction based on reduced graphene oxide/ferroferic oxide (rGO/Fe3O4) coupled with high performance liquid chromatography-diode array detector (HPLC-DAD), was proposed for the determination of naproxen and diclofenac sodium of non-steroidal anti-inflammatory drugs (NSAIDs) and bisphenol-A residue in tap water sample. Fe3O4 was assembled with graphene oxide by facile method. Several important parameters, such as extraction time, desorption time and desorption solvent were studied and optimized. Optimal conditions were then used for the extraction of NSAIDs and bisphenol-A from real samples, prior to HPLC-DAD analysis using C18 column. The proposed method provides good linearity in the range of 1.0-5.0 mg L-1 (R2 naproxene = 0.9983, R2 diclofenac = 0.9960) for NSAIDs and R2 = 0.9919 for bisphenol-A; limit of detection of 0.031 mg L-1 and 0.023 mg L-1 for naproxen and diclofenac, respectively and 0.1785 mg L-1 for bisphenol-A; limit of quantification for naproxen and diclofenac were 0.102 and 0.076 mg L-1, respectively and 0.5949 mg L-1 for bisphenol-A; relative recoveries between 66.21 and 105.60 % for diclofenac and naproxen, respectively and 72.74 % for bisphenol-A; and acceptable reproducibility relative standard deviation (RSD, n = 3) of 6.79 and 11.32 % for diclofenac and naproxen, respectively and 0.93 % for bisphenol-A. The method was successfully applied to tap water sample and the results indicates that small residue of bisphenol-A is present the sample while no traces of NSAIDs was detected.

scholarly journals Trace determination of chlorpheniramine in human plasma using magnetic dispersive solid-phase extraction based on a graphene oxide/Fe3O4@polythionine nanocomposite combined with high-performance liquid chromatography

RSC Advances ◽  
2017 ◽  
Vol 7 (84) ◽  
pp. 53210-53218 ◽  
Author(s):  
Maryam Ahmadi Daryakenary ◽  
Mohsen Zeeb
Keyword(s):  
High Performance Liquid Chromatography ◽  
Graphene Oxide ◽  
Liquid Chromatography ◽  
Solid Phase Extraction ◽  
Human Plasma ◽  
High Performance ◽  
Solid Phase ◽  
Phase Extraction ◽  
Dispersive Solid Phase Extraction

Graphene oxide/Fe3O4@polythionine (GO/Fe3O4@PTh) nanocomposite was fabricated for magnetic dispersive solid-phase extraction and high-performance liquid chromatography-ultraviolent detection (HPLC) of chlorpheniramine in human plasma.

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