scholarly journals Thermodynamic and Thermomicroscopy Study of Atorvastatin Calcium-Succinic Acid Binary Mixtures

2017 ◽  
Vol 17 (3) ◽  
pp. 485
Author(s):  
Yudi Wicaksono ◽  
Budipratiwi Wisudyaningsih ◽  
Frida Oktaningtias Widiarthi ◽  
Tri Agus Siswoyo
Keyword(s):  
Phase Diagram ◽  
Liquid Phase ◽  
Succinic Acid ◽  
Binary Mixtures ◽  
Mole Fraction ◽  
Roughness Parameter ◽  
Eutectic Point ◽  
Solid State Transformation ◽  
Atorvastatin Calcium ◽  
Solid Liquid

Binary mixtures of pharmaceuticals significantly affect the physical and chemical properties of each component. The aim of this work was to explore the thermal behavior and solid state transformation of binary mixture of atorvastatin calcium and succinic acid. The thermodynamics of binary mixtures of atorvastatin calcium - succinic acid were determined by differential scanning calorimeter. Meanwhile, thermomicroscopy and microstructure were determined by a polarized microscope equipped with a heating stage and camera. The results showed that melting points of atorvastatin calcium and succinic acid respectively were 159.35 and 188.51 °C. The solid-liquid phase diagram of atorvastatin calcium - succinic acid indicates the existence of two eutectic points at 136.57 °C and 120.96 °C respectively on the mole fraction of atorvastatin calcium 0.3 and 0.5. Tamman diagram accurately shows mole fraction of atorvastatin calcium at eutectic point 0.33 and 0.46 respectively for eutectic points 130.0 °C and 134.0 °C. Determination of Jackson’s roughness parameter showed a value of atorvastatin calcium, succinic acid and eutectic mixtures > 2 which indicates that the interfaces of remelting crystals were smooth. Microstructure of remelting crystal of atorvastatin calcium and succinic acid respectively was irregular form and crossed plates. The results of thermomicroscopy of binary mixtures of atorvastatin calcium-succinic acid were consistent with differential scanning calorimetry curves and solid-liquid phase diagram.

scholarly journals Diagram Fase dan Sifat Termodinamik Campuran Biner Ketoprofen-Asam Suksinat

2018 ◽  
Vol 19 (2) ◽  
pp. 99
Author(s):  
Yudi Wicaksono ◽  
Dwi Setyawan ◽  
S. Siswandono
Keyword(s):  
Phase Diagram ◽  
Liquid Phase ◽  
Thermodynamic Properties ◽  
Succinic Acid ◽  
Binary Mixtures ◽  
Equilibrium Phase ◽  
Heat Of Fusion ◽  
Eutectic System ◽  
Eutectic Type ◽  
Solid Liquid

The equilibrium phase diagram and thermodynamic properties of a mixture of drugs and additives are information related to various possible interaction processes between components. Therefore, we conducted a study of the phase diagrams and thermodynamic properties of binary mixtures of ketoprofen-succinic acid to estimate the types of interactions that may occur between these materials. The solid-liquid phase diagram of ketoprofen-succinic acid binary mixtures was determined by differential scanning calorimetry and composition of eutectic system was determined accurately using a Tamman diagram. The measurement of binary mixtures of ketoprofen-succinic acid with differential scanning calorimeter obtained the value of melting temperature and heat of fusion of ketoprofen- succinic acid system. The solid-liquid phase diagram of ketoprofen- succinic acid showed the formation of eutectic type phase diagram. The Tamman diagram showed accurately composition of the eutectic system of the Kp-SA binary mixtures at the mole fraction of Kp 0.87 and temperature 96.9oC.Keywords: ketoprofen, phase diagram, eutectic system, Tamman diagram

scholarly journals Solid-Liquid Phase Diagram of the Binary System Octadecanoic Acid and Octadecanol and the Thermal Chemical Property of the Composition at Eutectic Point

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Can Liu ◽  
Kaiyu Zhao ◽  
Yafei Guo ◽  
Liping Guo ◽  
Tianlong Deng
Keyword(s):  
Phase Diagram ◽  
Liquid Phase ◽  
Binary System ◽  
Phase Change ◽  
Mass Fraction ◽  
Eutectic Point ◽  
Octadecanoic Acid ◽  
Phase Change Temperature ◽  
Change Temperature ◽  
Solid Liquid

Phase diagram is a powerful tool to guide the exploitation of thermal energy materials. Heat storage technology of phase-change material (PCM) was widely used to solve major energy utilization problems on large energy consumption and low utilization efficiency. In this work, a novel solid-liquid phase diagram of the binary system octadecanoic acid (C18-acid) + octadecanol (C18-OH) was investigated using the differential scanning calorimeter (DSC). The phase-change temperature and phase-change enthalpies against the composition of C18-acid and C18-OH were determined experimentally, and then the binary phase diagram of T–X (X expresses the mass fraction of C18-OH in the two components of C18-acid and C18-OH) was established for the first time. The phase diagram belongs to a binary simple system with one eutectic point, and the content of C18-OH at eutectic point is 0.4 in mass fraction. Neither solid solution nor copolymer was formed. The thermal chemical properties on the phase-change latent heat (Q), phase-change temperature (Tp), and the thermal conductivity (λ) for the composition at the eutectic point of the binary system are 198.7 J·g−1, 44.2°C, and 0.2352 W·m−1·K−1, respectively. This result indicates that the material at eutectic point has a great potential to be used as energy storage material for supply of heat and scouring bath.

Solid-Liquid Equilibria for Binary Mixture of Dichlorophenols

2014 ◽  
Vol 881-883 ◽  
pp. 712-716
Author(s):  
Yan Fei Wang ◽  
Qi Shan Huang ◽  
Li Bin Yang ◽  
Liang Zhu
Keyword(s):  
Phase Diagram ◽  
Thermal Properties ◽  
Binary Mixture ◽  
Mole Fraction ◽  
Activity Coefficients ◽  
Binary Systems ◽  
Eutectic Point ◽  
Eutectic Type ◽  
Wilson Model ◽  
Solid Liquid

Differential Scanning Calorimeter (DSC) was used to investigate the thermal properties of 2,4-dichlorophenol+2,6-dichlorophenol and 2,4-dichlorophenol+2,3-dichlorophenol binary systems. The experimental results showed that The phase diagram of 2,4-dichlorophenol+2,6-dichlorophenol system was a simple eutectic type with the eutectic point at 294.99 K and 0.6200 mole fraction of 2,4dichlorophenol; The phase diagram of 2,4dichlorophenol+2,3dichlorophenol system was a simple eutectic type with the eutectic point at 291.86 K and 0.5834 mole fraction of 2,4dichlorophenol. Furthermore, the activity coefficients of components in mixtures of 2,4dichlorophenol+2,6dichlorophenol and2,4dichlorophenol+ 2,3dichlorophenol binary systems have been correlated by the Wilson model, respectively.

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