The Solid–Liquid Phase Diagram of Binary Mixtures Dissolved in an Inert Oil: Application to Ternary Blends that Can Form Organogels

2019 ◽  
Vol 97 (2) ◽  
pp. 117-124
Author(s):  
Hermanus M. Schaink
Keyword(s):  
Phase Diagram ◽  
Liquid Phase ◽  
Binary Mixtures ◽  
Ternary Blends ◽  
Solid Liquid

scholarly journals Diagram Fase dan Sifat Termodinamik Campuran Biner Ketoprofen-Asam Suksinat

2018 ◽  
Vol 19 (2) ◽  
pp. 99
Author(s):  
Yudi Wicaksono ◽  
Dwi Setyawan ◽  
S. Siswandono
Keyword(s):  
Phase Diagram ◽  
Liquid Phase ◽  
Thermodynamic Properties ◽  
Succinic Acid ◽  
Binary Mixtures ◽  
Equilibrium Phase ◽  
Heat Of Fusion ◽  
Eutectic System ◽  
Eutectic Type ◽  
Solid Liquid

The equilibrium phase diagram and thermodynamic properties of a mixture of drugs and additives are information related to various possible interaction processes between components. Therefore, we conducted a study of the phase diagrams and thermodynamic properties of binary mixtures of ketoprofen-succinic acid to estimate the types of interactions that may occur between these materials. The solid-liquid phase diagram of ketoprofen-succinic acid binary mixtures was determined by differential scanning calorimetry and composition of eutectic system was determined accurately using a Tamman diagram. The measurement of binary mixtures of ketoprofen-succinic acid with differential scanning calorimeter obtained the value of melting temperature and heat of fusion of ketoprofen- succinic acid system. The solid-liquid phase diagram of ketoprofen- succinic acid showed the formation of eutectic type phase diagram. The Tamman diagram showed accurately composition of the eutectic system of the Kp-SA binary mixtures at the mole fraction of Kp 0.87 and temperature 96.9oC.Keywords: ketoprofen, phase diagram, eutectic system, Tamman diagram

scholarly journals Thermodynamic and Thermomicroscopy Study of Atorvastatin Calcium-Succinic Acid Binary Mixtures

2017 ◽  
Vol 17 (3) ◽  
pp. 485
Author(s):  
Yudi Wicaksono ◽  
Budipratiwi Wisudyaningsih ◽  
Frida Oktaningtias Widiarthi ◽  
Tri Agus Siswoyo
Keyword(s):  
Phase Diagram ◽  
Liquid Phase ◽  
Succinic Acid ◽  
Binary Mixtures ◽  
Mole Fraction ◽  
Roughness Parameter ◽  
Eutectic Point ◽  
Solid State Transformation ◽  
Atorvastatin Calcium ◽  
Solid Liquid

Binary mixtures of pharmaceuticals significantly affect the physical and chemical properties of each component. The aim of this work was to explore the thermal behavior and solid state transformation of binary mixture of atorvastatin calcium and succinic acid. The thermodynamics of binary mixtures of atorvastatin calcium - succinic acid were determined by differential scanning calorimeter. Meanwhile, thermomicroscopy and microstructure were determined by a polarized microscope equipped with a heating stage and camera. The results showed that melting points of atorvastatin calcium and succinic acid respectively were 159.35 and 188.51 °C. The solid-liquid phase diagram of atorvastatin calcium - succinic acid indicates the existence of two eutectic points at 136.57 °C and 120.96 °C respectively on the mole fraction of atorvastatin calcium 0.3 and 0.5. Tamman diagram accurately shows mole fraction of atorvastatin calcium at eutectic point 0.33 and 0.46 respectively for eutectic points 130.0 °C and 134.0 °C. Determination of Jackson’s roughness parameter showed a value of atorvastatin calcium, succinic acid and eutectic mixtures > 2 which indicates that the interfaces of remelting crystals were smooth. Microstructure of remelting crystal of atorvastatin calcium and succinic acid respectively was irregular form and crossed plates. The results of thermomicroscopy of binary mixtures of atorvastatin calcium-succinic acid were consistent with differential scanning calorimetry curves and solid-liquid phase diagram.

Solid-liquid phase equilibrium diagrams of binary mixtures containing fatty acids, fatty alcohol compounds and tripalmitin using differential scanning calorimetry

2019 ◽  
Vol 497 ◽  
pp. 19-32 ◽  
Author(s):  
Fernanda Paludetto Pelaquim ◽  
Flávio Cardoso de Matos ◽  
Lisandro Pavie Cardoso ◽  
Eduardo Augusto Caldas Batista ◽  
Antonio José de Almeida Meirelles ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Differential Scanning Calorimetry ◽  
Phase Equilibrium ◽  
Liquid Phase ◽  
Binary Mixtures ◽  
Fatty Alcohol ◽  
Scanning Calorimetry ◽  
Solid Liquid

On the solid–liquid phase diagrams of binary mixtures of even saturated fatty alcohols: Systems exhibiting peritectic reaction

2014 ◽  
Vol 589 ◽  
pp. 137-147 ◽  
Author(s):  
Natália D.D. Carareto ◽  
Adenílson O. dos Santos ◽  
Marlus P. Rolemberg ◽  
Lisandro P. Cardoso ◽  
Mariana C. Costa ◽  
...  
Keyword(s):  
Liquid Phase ◽  
Phase Diagrams ◽  
Binary Mixtures ◽  
Peritectic Reaction ◽  
Fatty Alcohols ◽  
Solid Liquid
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