scholarly journals Synthesis, Radiochemical Purity Control and Stability of Scandium-46-1,4,7-triazacyclononane-1,4,7-triacetic acid (46Sc-NOTA)

2018 ◽  
Vol 18 (1) ◽  
pp. 153
Author(s):  
Duyeh Setiawan ◽  
Iwan Hastiawan ◽  
Asri Nurul Bashiroh
Keyword(s):  
Paper Chromatography ◽  
Half Life ◽  
Radiochemical Purity ◽  
Ph Effect ◽  
Gamma Emission ◽  
Several Variables ◽  
Beta Emission ◽  
Purity Control

Radiotherapy is one of healing method of cancer using radionuclide elements. The radionuclide scandium-46 (46Sc) has a half-life of 83.8 days, beta emission 0.35 MeV and gamma emission 899 and 1120 keV is suitable for studying the chemical aspects, synthesis and stability of scandium complex for radiotherapy. The purposes of this research are synthesis of scandium-46-1,4,7-triazacyclononane-1,4,7-triacetic acid (46Sc-NOTA) labeled compound based on formation of a complex bonding in stoichiometry between radioisotope 46Sc and 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) ligand, and radiochemical purity and stability assay of 46Sc-NOTA. In this research, conducted that optimum moles several variables, namely moles comparison and pH effect was used. The result are optimum conclusion of mole comparison between radioisotope and ligand was 1:2 (46Sc : NOTA) and environment at pH 5. The radiochemical purity and stability assay of 46Sc-NOTA was carried out by paper chromatography and the result showed that 46Sc-NOTA has radiochemical purity of 99.09 ± 0.2% and remained stable for 9 days.

Labelling of Bleomycin with Cobalt-57, Indium-111, Technetium-99m, Mercury-197, Lead-203, and Copper-67

1976 ◽  
Vol 15 (02) ◽  
pp. 86-90 ◽  
Author(s):  
M. A. P. C van de Poll ◽  
J. J. Rasker ◽  
H. Jurjens ◽  
M. G. Woldring ◽  
A. Versluis
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Paper Chromatography ◽  
Half Life ◽  
Radiochemical Purity ◽  
Gamma Ray ◽  
Clinical Use ◽  
A Value ◽  
Indium 111 ◽  
Layer Chromatography

SummaryThe radiochemical purity of the cobalt-57 complex of bleomycin could be enhanced by adjusting the pH of the final product to a value between 5 and 6. This radiopharmaceutical appeared to have better tumor visualizing properties compared to the not neutralized preparation.The clinical use of the cobalt-57 bleomycin complex is however limited by the long physical half-life of the label, causing a risk of radioactive contamination. It appeared to be possible to label bleomycin with radioactive cations (111In3+, 99mTc4+, 197Hg2+ and 67Cu2+) having suitable gamma ray energies and short half-lifes.These bleomycin complexes showed a high radiochemical purity judged by their behaviour on thin layer chromatography, paper chromatography, and electrophoresis, but their application as tumor visualizing radiopharmaceutical turned out to be disappointing compared with cobalt-57 bleomycin.

scholarly journals Method for Determining the Radiochemical Purity of Radiopharmaceuticals Based on Iodine-125, Iodine-131 and Samarium-153-oxabifor

2021 ◽  
Vol 9 (3) ◽  
pp. 217-220
Keyword(s):  
Paper Chromatography ◽  
Sodium Iodide ◽  
Nuclear Reactor ◽  
Radiochemical Purity ◽  
Electrophoretic Method ◽  
Iodine 131 ◽  
Iodine 125

iopharmaceuticals used in medicine for diagnostics, treatment, and anesthesia in various diseases. Radionuclide 125I was obtained by irradiation with neutrons of the enriched isotope 124Хе in a nuclear reactor. 131I was isolated from irradiated samples of TeO2 enriched in 130Те, and radionuclide 153Sm was obtained by irradiation of samples 152Sm2O3 in a nuclear reactor. The radiochemical purity of sodium iodide preparations labeled with 125I or 131I radionuclides was determined by the electrophoretic method, and the samarium-153-oxabifor preparation was determined by ascending paper chromatography. To determine the distribution of the activity of 125I, 131I, and 153Sm-oxabiphor by electrophoregrams and chromatograms, a γ-radiometric device Ludlum-2200 was used, which makes it possible to determine the radiochemical purity at the level of 99.9%.

THE PRODUCTION OF Na22 BY A (H3, n) REACTION IN A NUCLEAR REACTOR

1954 ◽  
Vol 32 (2) ◽  
pp. 94-97 ◽  
Author(s):  
L. G. Cook ◽  
K. D. Shafer
Keyword(s):  
Aluminum Alloy ◽  
Ion Exchange ◽  
Neutron Flux ◽  
Paper Chromatography ◽  
Half Life ◽  
Nuclear Reactor ◽  
Specific Activity ◽  
Separation And Purification

The positron emitting Na22 of 2.6 year half-life has been prepared in a nuclear reactor by the double reaction Li6(n, α)H3, Ne20(H3, n)Na22. The over-all yield was 2.3 × 10−7 atoms of Na22 per atom of tritium formed. Eleven grams of lithium as aluminum alloy turnings in a neon atmosphere at 200 p.s.i. was irradiated for 175 days in a neutron flux of about 4 × 1012 n./cm.2/sec. About 380 μc. of Na22 was obtained in a sodium extract having a specific activity of 10 mc. Na22/gm. of Na23. A specific activity in the curie/gm. level would be expected from a longer irradiation in the highest flux (6 × 1013 n./cm.2/sec.) in the NRX reactor. The separation and purification of the sodium proved practicable by paper chromatography or ion exchange; the analyses for trace Li and Na23 were carried out by radioactivation.

Half-life of rhenium: geologic and cosmologic ages

1984 ◽  
Vol 62 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Stanley N. Naldrett
Keyword(s):  
Organic Compound ◽  
Decay Rate ◽  
Liquid Scintillation Counting ◽  
Half Life ◽  
Liquid Scintillation ◽  
Scintillation Counting ◽  
Beta Emission

The transition by beta emission of 187Re to 187Os would offer an attractive method of determining geologic and cosmologic ages if the decay rate of 187Re was known. An improvement in the determination of the decay rate has been accomplished using an organic compound of rhenium in liquid scintillation counting that is monitored by standards of other pure beta emitting isotopes. The half-life of 187Re is estimated to be (3.5 ± 0.4) × 1010 yr.

THE BIOLOGICAL DIFFERENTIATION OF 99Mo AND 99Tcm IN RABBITS AND ITS EFFECT ON THE GAMMA-COUNTING RATE OF PLASMA SAMPLES

1966 ◽  
Vol 44 (3) ◽  
pp. 363-370
Author(s):  
G. A. Robinson ◽  
A. McCarter
Keyword(s):  
Half Life ◽  
Counting Rate ◽  
Plasma Samples ◽  
Nuclear Decay ◽  
Gamma Energy ◽  
Blood Samples ◽  
Daughter Nuclide ◽  
Gamma Counting ◽  
Beta Emission ◽  
Biological Differentiation

Thirty-one rabbits were each injected intravenously with 250–450 μcuries molybdate-99Mo in transient equilibrium with 99Tcm. Blood samples were taken at intervals from 0.5 to 48 hours after the isotope injections. The gamma-counting rate of the blood plasma was recorded at 13 intervals during the 96 hours subsequent to the bleedings. Gamma curves, uncorrected for nuclear decay, were biphasic for 151 of the 194 samples. Recognizable first components (mean half-life ± s.e.m., 6.12 ± 0.10 hours). represented the buildup of 99Tcm to equilibrium levels in 53 samples (38 of these from rabbits fed on control diets) and decay of "excess" 99Tcm in 101 others (65 for rabbits fed on diets containing 0.4% Na2MoO4). The second components (mean half-life 65.9 ± 1.1 hours) represented a condition of transient equilibrium between 99Mo present in the samples at time of bleeding and the daughter nuclide. Biological differentiation of 99Mo and 99Tcm as observed in this study indicated that the indiscriminate measurement of gamma emissions for 99Mo-containing systems may give apparent 99Mo concentrations 0.57–2.31 times the actual values. Counting of either the total beta emission or a specific 99Mo gamma energy is recommended when the measurement of 99Mo is attempted.

UPTAKE AND METABOLISM OF [1,2-3H]PROGESTERONE INJECTED INTRALUMINALLY INTO THE UTERI OF SPAYED MICE

1973 ◽  
Vol 58 (3) ◽  
pp. 555-562 ◽  
Author(s):  
B. F. CLARK
Keyword(s):  
Paper Chromatography ◽  
Half Life ◽  
Small Extent ◽  
Local Injection ◽  
Target Tissue ◽  
Plantaris Muscle ◽  
Tissue Paper ◽  
Selective Retention ◽  
Uptake And Metabolism

SUMMARY [1,2-3H]Progesterone (5–50 pg) injected intraluminally into the uterus of spayed mice was retained only to a small extent; producing a 'half-life' of about 30 min compared with > 240 min for [6,7-3H]oestradiol-17β (50 pg). Retention of progesterone by the uterus was not significantly different from that by the plantaris muscle, a non-target tissue. Paper chromatography of extracts indicated that metabolism of [1,2-3H]progesterone occurred in both the uterus and the vagina within 5 min of local injection. There was more metabolism in the vagina and it was qualitatively different. No selective retention of progesterone or its metabolites occurred in either organ. The proportion of the radioactivity present as progesterone over 120 min after injection remained constant.

Sign in / Sign up

Export Citation Format

Share Document