scholarly journals Vascular Cognitive Impairment in a Memory Clinic Population: Rationale and Design of the “Utrecht-Amsterdam Clinical Features and Prognosis in Vascular Cognitive Impairment” (TRACE-VCI) Study

2017 ◽  
Vol 6 (4) ◽  
pp. e60 ◽  
Author(s):  
Jooske Marije Funke Boomsma ◽  
Lieza Geertje Exalto ◽  
Frederik Barkhof ◽  
Esther van den Berg ◽  
Jeroen de Bresser ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Clinical Features ◽  
Vascular Cognitive Impairment ◽  
Memory Clinic ◽  
Clinic Population

Inter-Rater Reliability of the Diagnosis of Vascular Cognitive Impairment at a Memory Clinic

2000 ◽  
Vol 19 (4) ◽  
pp. 186-193 ◽  
Author(s):  
Carolyn Wentzel ◽  
Sultan Darvesh ◽  
Chris MacKnight ◽  
Catherine Shea ◽  
Kenneth Rockwood
Keyword(s):  
Cognitive Impairment ◽  
Vascular Cognitive Impairment ◽  
Memory Clinic ◽  
Rater Reliability

scholarly journals Prevalence and Predictors of Caregiver Burden in a Memory Clinic Population

2021 ◽  
pp. 1-9
Author(s):  
Rónán O’Caoimh ◽  
Mareeta Calnan ◽  
Arup Dhar ◽  
D. William Molloy
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Caregiver Burden ◽  
Neuropsychiatric Symptoms ◽  
University Hospital ◽  
Patient Specific ◽  
Subjective Cognitive Decline ◽  
Memory Clinic ◽  
People With Dementia ◽  
Clinic Population

Background: Although caregiver burden is common among carers of people with dementia, little is known about its prevalence and predictors among caregivers of patients attending memory clinics. Objective: To examine carer and patient-specific characteristics associated with caregiver burden across the cognitive spectrum in a memory clinic population. Methods: Consecutive patients referred to a university hospital geriatric memory clinic were included. Caregiver burden was scored using the Caregiver Burden Score (CBS), (modified Zarit), with scores≥15/30 suggesting burden. BPSD were measured with the dysfunctional behaviour rating instrument (DBRI). Cognition was screened using the Montreal Cognitive Assessment (MoCA) and Quick Mild Cognitive Impairment (Qmci) screen. Results: In all, 351 patients were included, median age 77 (±11) years; 65.5% were female. The prevalence of caregiver burden was 33.6% overall, increasing from 10.8% in subjective cognitive decline (SCD), to 15% in mild cognitive impairment (MCI) and 43% in dementia; CBS scores were significantly higher in dementia (p < 0.001). Caregivers with burden were significantly younger (p = 0.045) and were more likely to be adult children (p = 0.007). The CBS weakly correlated with the stage of cognitive impairment (r = 0.16) but had moderate correlation with MoCA (r = –0.54) and Qmci scores (r = –0.60). After adjustment for co-variates, DBRI scores alone independently predicted burden (odds ratio 1.23;1.11–1.35, p < 0.001). Conclusion: Caregiver burden is associated with the stage of cognitive impairment, with higher prevalence proportions in those with dementia compared with MCI and SCD. Only the severity of neuropsychiatric symptoms independently predicted caregiver burden in this population and its presence should prompt assessment for burden.

Mixed-Location Cerebral Microbleeds: An Imaging Biomarker for Cerebrovascular Pathology in Cognitive Impairment and Dementia in a Memory Clinic Population

2019 ◽  
Vol 71 (4) ◽  
pp. 1309-1320 ◽  
Author(s):  
Bibek Gyanwali ◽  
Muhammad Amin Shaik ◽  
Narayanaswamy Venketasubramanian ◽  
Christopher Chen ◽  
Saima Hilal
Keyword(s):  
Cognitive Impairment ◽  
Cerebral Microbleeds ◽  
Imaging Biomarker ◽  
Memory Clinic ◽  
Cerebrovascular Pathology ◽  
Clinic Population

scholarly journals Validity and reliability of the medial temporal lobe atrophy scale in a memory clinic population

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Anna Molinder ◽  
Doerthe Ziegelitz ◽  
Stephan E. Maier ◽  
Carl Eckerström
Keyword(s):  
Cognitive Impairment ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Age Group ◽  
Memory Clinic ◽  
Validity And Reliability ◽  
Medial Temporal Lobe Atrophy ◽  
Age Dependent ◽  
Clinic Population ◽  
Lobe Atrophy

Abstract Background Visual rating of medial temporal lobe atrophy (MTA) is often performed in conjunction with dementia workup. Most prior studies involved patients with known or probable Alzheimer’s disease (AD). This study investigated the validity and reliability of MTA in a memory clinic population. Methods MTA was rated in 752 MRI examinations, of which 105 were performed in cognitively healthy participants (CH), 184 in participants with subjective cognitive impairment, 249 in subjects with mild cognitive impairment, and 214 in patients with dementia, including AD, subcortical vascular dementia and mixed dementia. Hippocampal volumes, measured manually or using FreeSurfer, were available in the majority of cases. Intra- and interrater reliability was tested using Cohen’s weighted kappa. Correlation between MTA and quantitative hippocampal measurements was ascertained with Spearman’s rank correlation coefficient. Moreover, diagnostic ability of MTA was assessed with receiver operating characteristic (ROC) analysis and suitable, age-dependent MTA thresholds were determined. Results Rater agreement was moderate to substantial. MTA correlation with quantitative volumetric methods ranged from -0.20 (p< 0.05) to -0.68 (p < 0.001) depending on the quantitative method used. Both MTA and FreeSurfer are able to distinguish dementia subgroups from CH. Suggested age-dependent MTA thresholds are 1 for the age group below 75 years and 1.5 for the age group 75 years and older. Conclusions MTA can be considered a valid marker of medial temporal lobe atrophy and may thus be valuable in the assessment of patients with cognitive impairment, even in a heterogeneous patient population.

scholarly journals The prevalence and clinical features of epileptic seizures in a memory clinic population

Seizure ◽  
2019 ◽  
Vol 71 ◽  
pp. 83-92 ◽  
Author(s):  
John Baker ◽  
Tina Libretto ◽  
William Henley ◽  
Adam Zeman
Keyword(s):  
Clinical Features ◽  
Epileptic Seizures ◽  
Memory Clinic ◽  
Clinic Population

Clinical relevance of acute cerebral microinfarcts in vascular cognitive impairment

Neurology ◽  
2019 ◽  
Vol 92 (14) ◽  
pp. e1558-e1566 ◽  
Author(s):  
Doeschka A. Ferro ◽  
Hilde van den Brink ◽  
Lieza G. Exalto ◽  
Jooske M.F. Boomsma ◽  
Frederik Barkhof ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Brain Injury ◽  
Clinical Outcome ◽  
Vascular Cognitive Impairment ◽  
Cognitive Profile ◽  
Vascular Risk ◽  
Memory Clinic ◽  
Poor Clinical Outcome ◽  
Apparent Diffusion

ObjectiveTo determine the occurrence of acute cerebral microinfarcts (ACMIs) in memory clinic patients and relate their presence to vascular risk and cognitive profile, CSF and neuroimaging markers, and clinical outcome.MethodsThe TRACE-VCI study is a memory clinic cohort of patients with vascular brain injury on MRI (i.e., possible vascular cognitive impairment [VCI]). We included 783 patients (mean age 67.6 ± 8.5, 46% female) with available 3T diffusion-weighted imaging (DWI). ACMIs were defined as supratentorial DWI hyperintensities <5 mm with a corresponding hypo/isointense apparent diffusion coefficient signal and iso/hyperintense T2*-weighted signal.ResultsA total of 23 ACMIs were found in 16 of the 783 patients (2.0%). Patients with ACMIs did not differ in vascular risk or cognitive profile, but were more often diagnosed with vascular dementia (odds ratio [OR] 5.1; 95% confidence interval [CI] 1.4–18.9, p = 0.014). ACMI presence was associated with lower levels of β-amyloid (p < 0.004) and with vascular imaging markers (lacunar infarcts: OR 3.5, CI 1.3–9.6, p = 0.015; nonlacunar infarcts: OR 4.1, CI 1.4–12.5, p = 0.012; severe white matter hyperintensities: OR 4.8, CI 1.7–13.8, p = 0.004; microbleeds: OR 18.9, CI 2.5–144.0, p = 0.0001). After a median follow-up of 2.1 years, the risk of poor clinical outcome (composite of marked cognitive decline, major vascular event, death, and institutionalization) was increased among patients with ACMIs (hazard ratio 3.0; 1.4–6.0, p = 0.005).ConclusionIn patients with possible VCI, ACMI presence was associated with a high burden of cerebrovascular disease of both small and large vessel etiology and poor clinical outcome. ACMIs may thus be a novel marker of active vascular brain injury in these patients.

scholarly journals Sex differences in memory clinic patients with possible vascular cognitive impairment

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Lieza G. Exalto ◽  
Jooske M. F. Boomsma ◽  
Rosha Babapour Mofrad ◽  
Frederik Barkhof ◽  
Onno N. Groeneveld ◽  
...  
Keyword(s):  
Sex Differences ◽  
Cognitive Impairment ◽  
Vascular Cognitive Impairment ◽  
Memory Clinic
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