scholarly journals Sex differences in memory clinic patients with possible vascular cognitive impairment

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Lieza G. Exalto ◽  
Jooske M. F. Boomsma ◽  
Rosha Babapour Mofrad ◽  
Frederik Barkhof ◽  
Onno N. Groeneveld ◽  
...  
Keyword(s):  
Sex Differences ◽  
Cognitive Impairment ◽  
Vascular Cognitive Impairment ◽  
Memory Clinic

Inter-Rater Reliability of the Diagnosis of Vascular Cognitive Impairment at a Memory Clinic

2000 ◽  
Vol 19 (4) ◽  
pp. 186-193 ◽  
Author(s):  
Carolyn Wentzel ◽  
Sultan Darvesh ◽  
Chris MacKnight ◽  
Catherine Shea ◽  
Kenneth Rockwood
Keyword(s):  
Cognitive Impairment ◽  
Vascular Cognitive Impairment ◽  
Memory Clinic ◽  
Rater Reliability

scholarly journals Revealing the Influences of Sex Hormones and Sex Differences in Atrial Fibrillation and Vascular Cognitive Impairment

2021 ◽  
Vol 22 (16) ◽  
pp. 8776
Author(s):  
Ya-Ting Chang ◽  
Yung-Lung Chen ◽  
Hong-Yo Kang
Keyword(s):  
Atrial Fibrillation ◽  
Sex Differences ◽  
Cognitive Impairment ◽  
Sex Hormones ◽  
Disease Onset ◽  
Vascular Cognitive Impairment ◽  
Disease Diagnosis ◽  
Therapeutic Interventions ◽  
Organ Systems ◽  
Health And Disease

The impacts of sex differences on the biology of various organ systems and the influences of sex hormones on modulating health and disease have become increasingly relevant in clinical and biomedical research. A growing body of evidence has recently suggested fundamental sex differences in cardiovascular and cognitive function, including anatomy, pathophysiology, incidence and age of disease onset, symptoms affecting disease diagnosis, disease severity, progression, and treatment responses and outcomes. Atrial fibrillation (AF) is currently recognized as the most prevalent sustained arrhythmia and might contribute to the pathogenesis and progression of vascular cognitive impairment (VCI), including a range of cognitive deficits, from mild cognitive impairment to dementia. In this review, we describe sex-based differences and sex hormone functions in the physiology of the brain and vasculature and the pathophysiology of disorders therein, with special emphasis on AF and VCI. Deciphering how sex hormones and their receptor signaling (estrogen and androgen receptors) potentially impact on sex differences could help to reveal disease links between AF and VCI and identify therapeutic targets that may lead to potentially novel therapeutic interventions early in the disease course of AF and VCI.

scholarly journals Vascular Cognitive Impairment in a Memory Clinic Population: Rationale and Design of the “Utrecht-Amsterdam Clinical Features and Prognosis in Vascular Cognitive Impairment” (TRACE-VCI) Study

2017 ◽  
Vol 6 (4) ◽  
pp. e60 ◽  
Author(s):  
Jooske Marije Funke Boomsma ◽  
Lieza Geertje Exalto ◽  
Frederik Barkhof ◽  
Esther van den Berg ◽  
Jeroen de Bresser ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Clinical Features ◽  
Vascular Cognitive Impairment ◽  
Memory Clinic ◽  
Clinic Population

scholarly journals Sex Differences in the Relationship of Serum Vitamin B1 and B12 to Dementia Among Memory Clinic Outpatients in Japan

2021 ◽  
Vol 13 ◽  
Author(s):  
Ayako Miki ◽  
Ryuta Kinno ◽  
Hirotaka Ochiai ◽  
Satomi Kubota ◽  
Yukiko Mori ◽  
...  
Keyword(s):  
Sex Differences ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Vitamin B12 ◽  
Vitamin B1 ◽  
Serum Vitamin ◽  
University Hospital ◽  
Memory Clinic ◽  
Relationship Of ◽  
The Relationship

Dementia and cognitive impairment are considered to be one of the biggest social and medical problems. While there is a definite relationship between vitamin B and cognitive decline, this has yet to be fully assessed with regard to sex differences. Thus, the present study investigated the relationship of vitamin B1 or vitamin B12 with dementia in accordance with the sex in 188 patients who visited the Memory Clinic at Showa University Hospital in Japan from March 2016 to March 2019. Cognitive function was tested by the Japanese version of the Mini-Mental State Examination (MMSE) and Hasegawa Dementia Scale-Revised (HDS-R). Blood tests were performed to measure the vitamin levels. Logistic regression analysis was used to calculate the odds ratio (OR) for dementia and the 95% confidence interval (CI). Compared to the highest vitamin group (third tertile), the lowest vitamin group (first tertile) exhibited a significantly increased OR for dementia defined by MMSE for vitamin B1 (OR:3.73, 95% CI:1.52–9.16) and vitamin B12 (2.97, 1.22–7.28) among women. In contrast, vitamin levels were not significantly associated with dementia determined by MMSE in men. These findings were similar even when dementia was defined by HDS-R. The present study suggests that vitamin B1 plays a role in preventing development of dementia in women. Future longitudinal studies will need to be undertaken in order to examine whether decreasing vitamin levels occur before or after cognitive impairment, and whether maintaining a higher vitamin level can prevent a worsening of cognitive function and the development of dementia.

Clinical relevance of acute cerebral microinfarcts in vascular cognitive impairment

Neurology ◽  
2019 ◽  
Vol 92 (14) ◽  
pp. e1558-e1566 ◽  
Author(s):  
Doeschka A. Ferro ◽  
Hilde van den Brink ◽  
Lieza G. Exalto ◽  
Jooske M.F. Boomsma ◽  
Frederik Barkhof ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Brain Injury ◽  
Clinical Outcome ◽  
Vascular Cognitive Impairment ◽  
Cognitive Profile ◽  
Vascular Risk ◽  
Memory Clinic ◽  
Poor Clinical Outcome ◽  
Apparent Diffusion

ObjectiveTo determine the occurrence of acute cerebral microinfarcts (ACMIs) in memory clinic patients and relate their presence to vascular risk and cognitive profile, CSF and neuroimaging markers, and clinical outcome.MethodsThe TRACE-VCI study is a memory clinic cohort of patients with vascular brain injury on MRI (i.e., possible vascular cognitive impairment [VCI]). We included 783 patients (mean age 67.6 ± 8.5, 46% female) with available 3T diffusion-weighted imaging (DWI). ACMIs were defined as supratentorial DWI hyperintensities <5 mm with a corresponding hypo/isointense apparent diffusion coefficient signal and iso/hyperintense T2*-weighted signal.ResultsA total of 23 ACMIs were found in 16 of the 783 patients (2.0%). Patients with ACMIs did not differ in vascular risk or cognitive profile, but were more often diagnosed with vascular dementia (odds ratio [OR] 5.1; 95% confidence interval [CI] 1.4–18.9, p = 0.014). ACMI presence was associated with lower levels of β-amyloid (p < 0.004) and with vascular imaging markers (lacunar infarcts: OR 3.5, CI 1.3–9.6, p = 0.015; nonlacunar infarcts: OR 4.1, CI 1.4–12.5, p = 0.012; severe white matter hyperintensities: OR 4.8, CI 1.7–13.8, p = 0.004; microbleeds: OR 18.9, CI 2.5–144.0, p = 0.0001). After a median follow-up of 2.1 years, the risk of poor clinical outcome (composite of marked cognitive decline, major vascular event, death, and institutionalization) was increased among patients with ACMIs (hazard ratio 3.0; 1.4–6.0, p = 0.005).ConclusionIn patients with possible VCI, ACMI presence was associated with a high burden of cerebrovascular disease of both small and large vessel etiology and poor clinical outcome. ACMIs may thus be a novel marker of active vascular brain injury in these patients.

Prevalence of Vascular Cognitive Impairment Among a Veteran Population

2008 ◽  
Author(s):  
Ruth E. Yoash-Gantz ◽  
Kristin L. Humphrey ◽  
Jacqueline W. Friedman
Keyword(s):  
Cognitive Impairment ◽  
Vascular Cognitive Impairment
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